chlorzoxazone-7456 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the chlorzoxazone-7456 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AIM2 absent in melanoma 2
ALPK1 alpha-kinase 1
APC adenomatous polyposis coli
AQP3 aquaporin 3 (Gill blood group)
AURKA aurora kinase A
C5ORF45 chromosome 5 open reading frame 45
CC2D1A coiled-coil and C2 domain containing 1A
CD22 CD22 molecule
CPNE7 copine VII
DGCR2 DiGeorge syndrome critical region gene 2
DHRS9 dehydrogenase/reductase (SDR family) member 9
DMC1 DNA meiotic recombinase 1
DRD2 dopamine receptor D2
DST dystonin
FLCN folliculin
FLOT1 flotillin 1
FOXN3 forkhead box N3
FZD9 frizzled class receptor 9
GM2A GM2 ganglioside activator
GPR37L1 G protein-coupled receptor 37 like 1
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C
GRTP1 growth hormone regulated TBC protein 1
GSK3A glycogen synthase kinase 3 alpha
GYG2 glycogenin 2
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HAND2-AS1 HAND2 antisense RNA 1 (head to head)
HBP1 HMG-box transcription factor 1
HCG4 HLA complex group 4 (non-protein coding)
HHAT hedgehog acyltransferase
HOXD1 homeobox D1
IFNA17 interferon, alpha 17
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
INHBC inhibin, beta C
ISL1 ISL LIM homeobox 1
ITPKB inositol-trisphosphate 3-kinase B
JRK Jrk homolog (mouse)
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KDM8 lysine (K)-specific demethylase 8
KRT8 keratin 8, type II
LMAN1 lectin, mannose-binding, 1
LPIN1 lipin 1
LTBP4 latent transforming growth factor beta binding protein 4
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MATK megakaryocyte-associated tyrosine kinase
MED31 mediator complex subunit 31
MOB3B MOB kinase activator 3B
MOGAT2 monoacylglycerol O-acyltransferase 2
NF2 neurofibromin 2 (merlin)
NKX2-1 NK2 homeobox 1
NOS1 nitric oxide synthase 1 (neuronal)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NUDCD3 NudC domain containing 3
NYX nyctalopin
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLXNB1 plexin B1
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PRDM12 PR domain containing 12
PRDM9 PR domain containing 9
PRPH2 peripherin 2 (retinal degeneration, slow)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PVR poliovirus receptor
PXDC1 PX domain containing 1
RAB3D RAB3D, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RECQL5 RecQ protein-like 5
RGS12 regulator of G-protein signaling 12
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RPL7 ribosomal protein L7
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RREB1 ras responsive element binding protein 1
RYR2 ryanodine receptor 2 (cardiac)
S100A8 S100 calcium binding protein A8
SARM1 sterile alpha and TIR motif containing 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SIX2 SIX homeobox 2
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC26A10 solute carrier family 26, member 10
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SOCS6 suppressor of cytokine signaling 6
SOGA1 suppressor of glucose, autophagy associated 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
ST20 suppressor of tumorigenicity 20
STAB2 stabilin 2
STAT5B signal transducer and activator of transcription 5B
TBC1D5 TBC1 domain family, member 5
TBX5 T-box 5
TEK TEK tyrosine kinase, endothelial
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TIMELESS timeless circadian clock
TJAP1 tight junction associated protein 1 (peripheral)
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
WDR25 WD repeat domain 25
ZNF235 zinc finger protein 235
ZNF747 zinc finger protein 747
ZNF771 zinc finger protein 771

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
ANAPC2 anaphase promoting complex subunit 2
ASTE1 asteroid homolog 1 (Drosophila)
ATAD3A ATPase family, AAA domain containing 3A
BAGE B melanoma antigen
BPGM 2,3-bisphosphoglycerate mutase
BRD9 bromodomain containing 9
C16ORF59 chromosome 16 open reading frame 59
C17ORF62 chromosome 17 open reading frame 62
C1ORF109 chromosome 1 open reading frame 109
C1ORF112 chromosome 1 open reading frame 112
C2ORF44 chromosome 2 open reading frame 44
CASD1 CAS1 domain containing 1
CBX8 chromobox homolog 8
CCDC85C coiled-coil domain containing 85C
CCNO cyclin O
CCS copper chaperone for superoxide dismutase
CENPJ centromere protein J
CHML choroideremia-like (Rab escort protein 2)
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
CTSV cathepsin V
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8
DNM1 dynamin 1
ECI2 enoyl-CoA delta isomerase 2
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
ESRRA estrogen-related receptor alpha
FA2H fatty acid 2-hydroxylase
FAM222B family with sequence similarity 222, member B
FKBP10 FK506 binding protein 10, 65 kDa
FZD2 frizzled class receptor 2
GDAP1 ganglioside induced differentiation associated protein 1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLMN glomulin, FKBP associated protein
GPATCH2 G patch domain containing 2
GPR87 G protein-coupled receptor 87
GRWD1 glutamate-rich WD repeat containing 1
HHLA3 HERV-H LTR-associating 3
HINFP histone H4 transcription factor
HIST1H2AJ histone cluster 1, H2aj
HLA-J major histocompatibility complex, class I, J (pseudogene)
HMOX1 heme oxygenase 1
INF2 inverted formin, FH2 and WH2 domain containing
IRF2 interferon regulatory factor 2
KIFAP3 kinesin-associated protein 3
KLHL26 kelch-like family member 26
KLHL36 kelch-like family member 36
LMCD1 LIM and cysteine-rich domains 1
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LYPD1 LY6/PLAUR domain containing 1
MAGEF1 melanoma antigen family F1
MAP1S microtubule-associated protein 1S
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MBNL3 muscleblind-like splicing regulator 3
METTL2B methyltransferase like 2B
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NHLRC2 NHL repeat containing 2
NMRK1 nicotinamide riboside kinase 1
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PEX11A peroxisomal biogenesis factor 11 alpha
PEX26 peroxisomal biogenesis factor 26
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PLEKHO1 pleckstrin homology domain containing, family O member 1
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PTTG3P pituitary tumor-transforming 3, pseudogene
PYCRL pyrroline-5-carboxylate reductase-like
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
REPS2 RALBP1 associated Eps domain containing 2
RFTN1 raftlin, lipid raft linker 1
RLN2 relaxin 2
RNF25 ring finger protein 25
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPUSD2 RNA pseudouridylate synthase domain containing 2
SALL2 spalt-like transcription factor 2
SARS2 seryl-tRNA synthetase 2, mitochondrial
SH2B3 SH2B adaptor protein 3
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SSFA2 sperm specific antigen 2
STBD1 starch binding domain 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM127 transmembrane protein 127
TMUB2 transmembrane and ubiquitin-like domain containing 2
TRIM25 tripartite motif containing 25
TTC4 tetratricopeptide repeat domain 4
UBXN6 UBX domain protein 6
UFSP2 UFM1-specific peptidase 2
ULBP2 UL16 binding protein 2
USB1 U6 snRNA biogenesis 1
XPA xeroderma pigmentosum, complementation group A
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZCCHC2 zinc finger, CCHC domain containing 2
ZCCHC6 zinc finger, CCHC domain containing 6
ZMAT5 zinc finger, matrin-type 5
ZNF33B zinc finger protein 33B
ZNF443 zinc finger protein 443
ZNF8 zinc finger protein 8