chlorzoxazone-2263 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the chlorzoxazone-2263 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
AHCYL1 adenosylhomocysteinase-like 1
AKAP9 A kinase (PRKA) anchor protein 9
ATF7 activating transcription factor 7
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BMP10 bone morphogenetic protein 10
CALCR calcitonin receptor
CCL23 chemokine (C-C motif) ligand 23
CD1E CD1e molecule
CD48 CD48 molecule
CD53 CD53 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CPA2 carboxypeptidase A2 (pancreatic)
CPB1 carboxypeptidase B1 (tissue)
CSNK1G1 casein kinase 1, gamma 1
CTNNA2 catenin (cadherin-associated protein), alpha 2
CUBN cubilin (intrinsic factor-cobalamin receptor)
CXADR coxsackie virus and adenovirus receptor
DAPK1 death-associated protein kinase 1
DLC1 DLC1 Rho GTPase activating protein
DNASE1L2 deoxyribonuclease I-like 2
DTNB dystrobrevin, beta
EHMT2 euchromatic histone-lysine N-methyltransferase 2
ETV5 ets variant 5
FGFR1 fibroblast growth factor receptor 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GAS7 growth arrest-specific 7
GLS glutaminase
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
HCRP1 hepatocellular carcinoma-related HCRP1
HFE hemochromatosis
HSF2BP heat shock transcription factor 2 binding protein
IDI2-AS1 IDI2 antisense RNA 1
INPP5J inositol polyphosphate-5-phosphatase J
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2
KEL Kell blood group, metallo-endopeptidase
KIAA1462 KIAA1462
KIF25-AS1 KIF25 antisense RNA 1
KIF5A kinesin family member 5A
KLRB1 killer cell lectin-like receptor subfamily B, member 1
KRT38 keratin 38, type I
LTB lymphotoxin beta (TNF superfamily, member 3)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MTRF1L mitochondrial translational release factor 1-like
NLGN1 neuroligin 1
NPAS3 neuronal PAS domain protein 3
NR6A1 nuclear receptor subfamily 6, group A, member 1
PARD6B par-6 family cell polarity regulator beta
PKNOX1 PBX/knotted 1 homeobox 1
PKNOX2 PBX/knotted 1 homeobox 2
POU5F1B POU class 5 homeobox 1B
RAD52 RAD52 homolog (S. cerevisiae)
RAP1GAP RAP1 GTPase activating protein
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RNF126P1 ring finger protein 126 pseudogene 1
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
S100A8 S100 calcium binding protein A8
SAMD9 sterile alpha motif domain containing 9
SCD5 stearoyl-CoA desaturase 5
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
SH2D3A SH2 domain containing 3A
SIGLEC6 sialic acid binding Ig-like lectin 6
SIPA1L3 signal-induced proliferation-associated 1 like 3
SIRT5 sirtuin 5
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13
SLIT1 slit homolog 1 (Drosophila)
SMC4 structural maintenance of chromosomes 4
SOS2 son of sevenless homolog 2 (Drosophila)
SPATS2L spermatogenesis associated, serine-rich 2-like
SQSTM1 sequestosome 1
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
SRPK3 SRSF protein kinase 3
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TAC3 tachykinin 3
TBX5 T-box 5
TEX15 testis expressed 15
TMEM63A transmembrane protein 63A
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TRA T cell receptor alpha locus
TRAF3IP3 TRAF3 interacting protein 3
TSSK2 testis-specific serine kinase 2
TTLL4 tubulin tyrosine ligase-like family member 4
TUBA3C tubulin, alpha 3c
TUBB7P tubulin, beta 7, pseudogene
UBA6 ubiquitin-like modifier activating enzyme 6
USB1 U6 snRNA biogenesis 1
VPS13B vacuolar protein sorting 13 homolog B (yeast)
WSCD1 WSC domain containing 1
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZNF235 zinc finger protein 235

decreased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACSL4 acyl-CoA synthetase long-chain family member 4
AEN apoptosis enhancing nuclease
APLP1 amyloid beta (A4) precursor-like protein 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARMC6 armadillo repeat containing 6
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BGLAP bone gamma-carboxyglutamate (gla) protein
C3 complement component 3
C7ORF43 chromosome 7 open reading frame 43
CALML5 calmodulin-like 5
CAMK1 calcium/calmodulin-dependent protein kinase I
CARM1 coactivator-associated arginine methyltransferase 1
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBX8 chromobox homolog 8
CCDC69 coiled-coil domain containing 69
CD3EAP CD3e molecule, epsilon associated protein
CDK18 cyclin-dependent kinase 18
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLDN9 claudin 9
CORO7 coronin 7
CRY2 cryptochrome circadian clock 2
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DGAT1 diacylglycerol O-acyltransferase 1
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DUSP13 dual specificity phosphatase 13
DVL1 dishevelled segment polarity protein 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNA3 ephrin-A3
EGFL7 EGF-like-domain, multiple 7
EPHX2 epoxide hydrolase 2, cytoplasmic
ERCC6 excision repair cross-complementation group 6
FAM120C family with sequence similarity 120C
FAM204A family with sequence similarity 204, member A
FBXO22 F-box protein 22
FBXO31 F-box protein 31
FXR2 fragile X mental retardation, autosomal homolog 2
GLB1L2 galactosidase, beta 1-like 2
GRB7 growth factor receptor-bound protein 7
HDAC11 histone deacetylase 11
HS1BP3 HCLS1 binding protein 3
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
HSPA1L heat shock 70kDa protein 1-like
IFI35 interferon-induced protein 35
IL12RB1 interleukin 12 receptor, beta 1
IL17RA interleukin 17 receptor A
ITPKB inositol-trisphosphate 3-kinase B
KLHL26 kelch-like family member 26
KRT24 keratin 24, type I
LIN7B lin-7 homolog B (C. elegans)
LINC00115 long intergenic non-protein coding RNA 115
LRRC61 leucine rich repeat containing 61
LYPD3 LY6/PLAUR domain containing 3
METTL16 methyltransferase like 16
MRPL44 mitochondrial ribosomal protein L44
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NLRX1 NLR family member X1
NOL12 nucleolar protein 12
NPTX1 neuronal pentraxin I
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PES1 pescadillo ribosomal biogenesis factor 1
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PPT2 palmitoyl-protein thioesterase 2
PRAF2 PRA1 domain family, member 2
PRODH proline dehydrogenase (oxidase) 1
PYCRL pyrroline-5-carboxylate reductase-like
PYGB phosphorylase, glycogen; brain
QTRT1 queuine tRNA-ribosyltransferase 1
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RLN1 relaxin 1
RPL23AP32 ribosomal protein L23a pseudogene 32
SCUBE2 signal peptide, CUB domain, EGF-like 2
SECTM1 secreted and transmembrane 1
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SIK1 salt-inducible kinase 1
SIX1 SIX homeobox 1
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM132A transmembrane protein 132A
TMUB2 transmembrane and ubiquitin-like domain containing 2
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TRIM5 tripartite motif containing 5
TSPAN1 tetraspanin 1
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UBXN6 UBX domain protein 6
UNC93B1 unc-93 homolog B1 (C. elegans)
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VIM vimentin
VIPR1 vasoactive intestinal peptide receptor 1
XAB2 XPA binding protein 2
YY2 YY2 transcription factor
ZNF324 zinc finger protein 324