chlorzoxazone-2100 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the chlorzoxazone-2100 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACACB acetyl-CoA carboxylase beta
ACVR2B activin A receptor, type IIB
ADRBK2 adrenergic, beta, receptor kinase 2
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ALDOB aldolase B, fructose-bisphosphate
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ATXN7 ataxin 7
BAX BCL2-associated X protein
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BMP4 bone morphogenetic protein 4
C16ORF59 chromosome 16 open reading frame 59
C16ORF62 chromosome 16 open reading frame 62
CD40 CD40 molecule, TNF receptor superfamily member 5
CD79A CD79a molecule, immunoglobulin-associated alpha
CDC25C cell division cycle 25C
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21
CISH cytokine inducible SH2-containing protein
CNTNAP2 contactin associated protein-like 2
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
ELOVL2 ELOVL fatty acid elongase 2
ELOVL5 ELOVL fatty acid elongase 5
ETV1 ets variant 1
EYA4 EYA transcriptional coactivator and phosphatase 4
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FCF1 FCF1 rRNA-processing protein
GABARAPL3 GABA(A) receptors associated protein like 3, pseudogene
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GAL3ST4 galactose-3-O-sulfotransferase 4
GSTA3 glutathione S-transferase alpha 3
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HIRA histone cell cycle regulator
HIST1H2AK histone cluster 1, H2ak
HOXB5 homeobox B5
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IL6ST interleukin 6 signal transducer
LINC00472 long intergenic non-protein coding RNA 472
LPAR3 lysophosphatidic acid receptor 3
LPP LIM domain containing preferred translocation partner in lipoma
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
MED16 mediator complex subunit 16
MEF2D myocyte enhancer factor 2D
NF1 neurofibromin 1
NOL12 nucleolar protein 12
NR5A2 nuclear receptor subfamily 5, group A, member 2
NUP160 nucleoporin 160kDa
OR1G1 olfactory receptor, family 1, subfamily G, member 1
OSGIN2 oxidative stress induced growth inhibitor family member 2
PAX9 paired box 9
PBX1 pre-B-cell leukemia homeobox 1
PCDH9 protocadherin 9
PDE4DIP phosphodiesterase 4D interacting protein
PDGFB platelet-derived growth factor beta polypeptide
PDK3 pyruvate dehydrogenase kinase, isozyme 3
PDLIM7 PDZ and LIM domain 7 (enigma)
PEX11A peroxisomal biogenesis factor 11 alpha
PEX26 peroxisomal biogenesis factor 26
PHLDB1 pleckstrin homology-like domain, family B, member 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
POLH polymerase (DNA directed), eta
PRB1 proline-rich protein BstNI subfamily 1
PRDM1 PR domain containing 1, with ZNF domain
RAB2A RAB2A, member RAS oncogene family
RAB31 RAB31, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
REL v-rel avian reticuloendotheliosis viral oncogene homolog
REN renin
REST RE1-silencing transcription factor
RGS14 regulator of G-protein signaling 14
RGS4 regulator of G-protein signaling 4
RPL23AP32 ribosomal protein L23a pseudogene 32
RRAD Ras-related associated with diabetes
SEC63 SEC63 homolog (S. cerevisiae)
SERHL2 serine hydrolase-like 2
SLC17A2 solute carrier family 17, member 2
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SOX12 SRY (sex determining region Y)-box 12
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
STRA6 stimulated by retinoic acid 6
STXBP6 syntaxin binding protein 6 (amisyn)
SYNE1 spectrin repeat containing, nuclear envelope 1
TBX2 T-box 2
TIAM1 T-cell lymphoma invasion and metastasis 1
TLE4 transducin-like enhancer of split 4
TMEM259 transmembrane protein 259
TNC tenascin C
TSPAN32 tetraspanin 32
TTC9 tetratricopeptide repeat domain 9
USP12 ubiquitin specific peptidase 12
YIPF4 Yip1 domain family, member 4
ZFHX3 zinc finger homeobox 3
ZKSCAN3 zinc finger with KRAB and SCAN domains 3

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANG angiogenin, ribonuclease, RNase A family, 5
ANGPTL4 angiopoietin-like 4
ANKFY1 ankyrin repeat and FYVE domain containing 1
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
BAG4 BCL2-associated athanogene 4
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
C1ORF112 chromosome 1 open reading frame 112
C7ORF43 chromosome 7 open reading frame 43
C8ORF60 chromosome 8 open reading frame 60
CAMTA2 calmodulin binding transcription activator 2
CCDC101 coiled-coil domain containing 101
CCL20 chemokine (C-C motif) ligand 20
CCS copper chaperone for superoxide dismutase
CFD complement factor D (adipsin)
CORO1A coronin, actin binding protein, 1A
CPA4 carboxypeptidase A4
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DGKD diacylglycerol kinase, delta 130kDa
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
ESM1 endothelial cell-specific molecule 1
FGGY FGGY carbohydrate kinase domain containing
FKBP10 FK506 binding protein 10, 65 kDa
FPGS folylpolyglutamate synthase
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GLCE glucuronic acid epimerase
GPATCH2 G patch domain containing 2
HHLA3 HERV-H LTR-associating 3
IRF2 interferon regulatory factor 2
IRF2BP1 interferon regulatory factor 2 binding protein 1
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12
KDM7A lysine (K)-specific demethylase 7A
KLHL36 kelch-like family member 36
KRI1 KRI1 homolog (S. cerevisiae)
LIG1 ligase I, DNA, ATP-dependent
LZTR1 leucine-zipper-like transcription regulator 1
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MPI mannose phosphate isomerase
MVP major vault protein
NDRG4 NDRG family member 4
NHLRC2 NHL repeat containing 2
NOD1 nucleotide-binding oligomerization domain containing 1
NPY1R neuropeptide Y receptor Y1
OLFML2A olfactomedin-like 2A
ORAI3 ORAI calcium release-activated calcium modulator 3
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PARM1 prostate androgen-regulated mucin-like protein 1
PC pyruvate carboxylase
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PHGDH phosphoglycerate dehydrogenase
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PISD phosphatidylserine decarboxylase
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PLEKHO2 pleckstrin homology domain containing, family O member 2
POMT2 protein-O-mannosyltransferase 2
PPP2R2D protein phosphatase 2, regulatory subunit B, delta
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
RIN1 Ras and Rab interactor 1
RNF31 ring finger protein 31
RPAP2 RNA polymerase II associated protein 2
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SETD6 SET domain containing 6
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SLC46A3 solute carrier family 46, member 3
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SMG9 SMG9 nonsense mediated mRNA decay factor
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SNHG3 small nucleolar RNA host gene 3
SPATA2L spermatogenesis associated 2-like
SPEG SPEG complex locus
SYNPO synaptopodin
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TGFB3 transforming growth factor, beta 3
THOP1 thimet oligopeptidase 1
TM7SF2 transmembrane 7 superfamily member 2
TMOD3 tropomodulin 3 (ubiquitous)
TSPYL2 TSPY-like 2
ULBP2 UL16 binding protein 2
USP18 ubiquitin specific peptidase 18
USP8 ubiquitin specific peptidase 8
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
XPC xeroderma pigmentosum, complementation group C
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
YEATS2 YEATS domain containing 2
ZBTB25 zinc finger and BTB domain containing 25
ZBTB3 zinc finger and BTB domain containing 3
ZBTB48 zinc finger and BTB domain containing 48
ZNF107 zinc finger protein 107
ZNF394 zinc finger protein 394
ZNF551 zinc finger protein 551