chlorzoxazone-1416 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the chlorzoxazone-1416 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSBG2 acyl-CoA synthetase bubblegum family member 2
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
AIM1L absent in melanoma 1-like
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ALX3 ALX homeobox 3
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BIRC7 baculoviral IAP repeat containing 7
CACFD1 calcium channel flower domain containing 1
CALB2 calbindin 2
CAMKV CaM kinase-like vesicle-associated
CAPN2 calpain 2, (m/II) large subunit
CC2D1A coiled-coil and C2 domain containing 1A
CLTA clathrin, light chain A
COL18A1 collagen, type XVIII, alpha 1
COL6A2 collagen, type VI, alpha 2
COMT catechol-O-methyltransferase
CORT cortistatin
CPM carboxypeptidase M
CPNE7 copine VII
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DOC2B double C2-like domains, beta
DTX2 deltex 2, E3 ubiquitin ligase
EIF1 eukaryotic translation initiation factor 1
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM214B family with sequence similarity 214, member B
FBXO31 F-box protein 31
FGF4 fibroblast growth factor 4
FGFR1 fibroblast growth factor receptor 1
FMO4 flavin containing monooxygenase 4
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GNL1 guanine nucleotide binding protein-like 1
GPR35 G protein-coupled receptor 35
GSTA4 glutathione S-transferase alpha 4
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HAMP hepcidin antimicrobial peptide
HOXB1 homeobox B1
HOXC4 homeobox C4
IGHA1 immunoglobulin heavy constant alpha 1
INO80B INO80 complex subunit B
IQCC IQ motif containing C
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNK10 potassium channel, two pore domain subfamily K, member 10
KIF25 kinesin family member 25
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4
LIMS2 LIM and senescent cell antigen-like domains 2
MIIP migration and invasion inhibitory protein
MRC2 mannose receptor, C type 2
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
NCR2 natural cytotoxicity triggering receptor 2
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NPEPL1 aminopeptidase-like 1
OR2H2 olfactory receptor, family 2, subfamily H, member 2
PHF3 PHD finger protein 3
PIN1P1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 pseudogene 1
PLCG1 phospholipase C, gamma 1
PLD2 phospholipase D2
PPARA peroxisome proliferator-activated receptor alpha
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PRB1 proline-rich protein BstNI subfamily 1
PRB3 proline-rich protein BstNI subfamily 3
PRLH prolactin releasing hormone
PRODH2 proline dehydrogenase (oxidase) 2
RAB2A RAB2A, member RAS oncogene family
RAB40B RAB40B, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
REM1 RAS (RAD and GEM)-like GTP-binding 1
RNF39 ring finger protein 39
RPL23AP32 ribosomal protein L23a pseudogene 32
RRAD Ras-related associated with diabetes
SCN5A sodium channel, voltage gated, type V alpha subunit
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SFTPC surfactant protein C
SLC39A2 solute carrier family 39 (zinc transporter), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SPDEF SAM pointed domain containing ETS transcription factor
SYN2 synapsin II
TBX1 T-box 1
TFF1 trefoil factor 1
TJAP1 tight junction associated protein 1 (peripheral)
TMCC2 transmembrane and coiled-coil domain family 2
TMEM212 transmembrane protein 212
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TRAPPC9 trafficking protein particle complex 9
TSPO2 translocator protein 2
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UBTD1 ubiquitin domain containing 1
VGF VGF nerve growth factor inducible
VIPR2 vasoactive intestinal peptide receptor 2
WDR62 WD repeat domain 62
WIPI2 WD repeat domain, phosphoinositide interacting 2
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
ZC3H7B zinc finger CCCH-type containing 7B
ZMIZ2 zinc finger, MIZ-type containing 2

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ADAM15 ADAM metallopeptidase domain 15
AKT1 v-akt murine thymoma viral oncogene homolog 1
APOC2 apolipoprotein C-II
BCL7B B-cell CLL/lymphoma 7B
BCL7C B-cell CLL/lymphoma 7C
C11ORF49 chromosome 11 open reading frame 49
C9ORF114 chromosome 9 open reading frame 114
CAPNS1 calpain, small subunit 1
CDK5 cyclin-dependent kinase 5
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CMC4 C-x(9)-C motif containing 4
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DHRS7B dehydrogenase/reductase (SDR family) member 7B
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8
DMXL1 Dmx-like 1
EIF3H eukaryotic translation initiation factor 3, subunit H
EMC9 ER membrane protein complex subunit 9
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative)
ERCC2 excision repair cross-complementation group 2
FANCF Fanconi anemia, complementation group F
FZD2 frizzled class receptor 2
GBAP1 glucosidase, beta, acid pseudogene 1
GEMIN6 gem (nuclear organelle) associated protein 6
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GOLM1 golgi membrane protein 1
GOLPH3L golgi phosphoprotein 3-like
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HIST1H2BE histone cluster 1, H2be
IFITM3 interferon induced transmembrane protein 3
IP6K1 inositol hexakisphosphate kinase 1
JOSD1 Josephin domain containing 1
KEAP1 kelch-like ECH-associated protein 1
KLF13 Kruppel-like factor 13
KLF2 Kruppel-like factor 2
KLHL21 kelch-like family member 21
LAMP5 lysosomal-associated membrane protein family, member 5
LMAN2L lectin, mannose-binding 2-like
MIS18BP1 MIS18 binding protein 1
MNAT1 MNAT CDK-activating kinase assembly factor 1
MON1B MON1 secretory trafficking family member B
MPG N-methylpurine-DNA glycosylase
MT1HL1 metallothionein 1H-like 1
MTG1 mitochondrial ribosome-associated GTPase 1
MYLIP myosin regulatory light chain interacting protein
NADSYN1 NAD synthetase 1
NAGK N-acetylglucosamine kinase
NCAPH non-SMC condensin I complex, subunit H
NDE1 nudE neurodevelopment protein 1
NEU1 sialidase 1 (lysosomal sialidase)
NFE2 nuclear factor, erythroid 2
NRBP1 nuclear receptor binding protein 1
NVL nuclear VCP-like
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
ORC1 origin recognition complex, subunit 1
ORC3 origin recognition complex, subunit 3
PAGR1 PAXIP1 associated glutamate-rich protein 1
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PCTP phosphatidylcholine transfer protein
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2
PEMT phosphatidylethanolamine N-methyltransferase
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
POMT1 protein-O-mannosyltransferase 1
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae)
PPIEL peptidylprolyl isomerase E-like pseudogene
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PTOV1 prostate tumor overexpressed 1
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RAB4B RAB4B, member RAS oncogene family
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBM10 RNA binding motif protein 10
RECQL4 RecQ protein-like 4
SAC3D1 SAC3 domain containing 1
SMG9 SMG9 nonsense mediated mRNA decay factor
SNX6 sorting nexin 6
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TMEM127 transmembrane protein 127
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAPPC12 trafficking protein particle complex 12
TRIB1 tribbles pseudokinase 1
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TTC23 tetratricopeptide repeat domain 23
UBE2M ubiquitin-conjugating enzyme E2M
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VILL villin-like
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae)
WDR41 WD repeat domain 41
WDR46 WD repeat domain 46
WDR6 WD repeat domain 6
YIPF1 Yip1 domain family, member 1
ZC3H3 zinc finger CCCH-type containing 3
ZNHIT2 zinc finger, HIT-type containing 2