chlortetracycline-6761 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the chlortetracycline-6761 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM22 ADAM metallopeptidase domain 22
ANKRD12 ankyrin repeat domain 12
ANKRD6 ankyrin repeat domain 6
APLP2 amyloid beta (A4) precursor-like protein 2
ASIC2 acid sensing (proton gated) ion channel 2
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
AURKA aurora kinase A
B9D1 B9 protein domain 1
BMP8B bone morphogenetic protein 8b
BNC1 basonuclin 1
BTG2 BTG family, member 2
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CDC42 cell division cycle 42
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CORO7 coronin 7
DDO D-aspartate oxidase
DHRS7 dehydrogenase/reductase (SDR family) member 7
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1
EIF5B eukaryotic translation initiation factor 5B
ELOVL5 ELOVL fatty acid elongase 5
ERAP1 endoplasmic reticulum aminopeptidase 1
FAM134B family with sequence similarity 134, member B
FBXO11 F-box protein 11
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FLOT1 flotillin 1
FOXG1 forkhead box G1
GPATCH4 G patch domain containing 4
GRSF1 G-rich RNA sequence binding factor 1
GSTTP1 glutathione S-transferase theta pseudogene 1
GUK1 guanylate kinase 1
HIC2 hypermethylated in cancer 2
HIST1H2BM histone cluster 1, H2bm
HIST2H2AA3 histone cluster 2, H2aa3
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IER3IP1 immediate early response 3 interacting protein 1
IFFO1 intermediate filament family orphan 1
IL1A interleukin 1, alpha
ING4 inhibitor of growth family, member 4
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KRAS Kirsten rat sarcoma viral oncogene homolog
LAG3 lymphocyte-activation gene 3
LATS1 large tumor suppressor kinase 1
LEF1 lymphoid enhancer-binding factor 1
LGALS8 lectin, galactoside-binding, soluble, 8
LGALS9 lectin, galactoside-binding, soluble, 9
LPPR4 lipid phosphate phosphatase-related protein type 4
LYRM9 LYR motif containing 9
MAK male germ cell-associated kinase
MARCKS myristoylated alanine-rich protein kinase C substrate
MEF2D myocyte enhancer factor 2D
MRPL52 mitochondrial ribosomal protein L52
NOP14-AS1 NOP14 antisense RNA 1
NOP16 NOP16 nucleolar protein
NPEPPS aminopeptidase puromycin sensitive
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PAOX polyamine oxidase (exo-N4-amino)
PDCD2 programmed cell death 2
PEX7 peroxisomal biogenesis factor 7
PGK1 phosphoglycerate kinase 1
PMCH pro-melanin-concentrating hormone
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
POU6F1 POU class 6 homeobox 1
PRRC2C proline-rich coiled-coil 2C
RAG1 recombination activating gene 1
RGS10 regulator of G-protein signaling 10
RHEB Ras homolog enriched in brain
RHO rhodopsin
RPAIN RPA interacting protein
RPL14 ribosomal protein L14
RPL38 ribosomal protein L38
RPLP2 ribosomal protein, large, P2
RPS11 ribosomal protein S11
RQCD1 RCD1 required for cell differentiation1 homolog (S. pombe)
S100A13 S100 calcium binding protein A13
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SMAD4 SMAD family member 4
SP100 SP100 nuclear antigen
TFEB transcription factor EB
TFG TRK-fused gene
THAP9 THAP domain containing 9
TM6SF1 transmembrane 6 superfamily member 1
TMEM231 transmembrane protein 231
TPM1 tropomyosin 1 (alpha)
TTLL3 tubulin tyrosine ligase-like family member 3
VDAC3 voltage-dependent anion channel 3
WAPAL wings apart-like homolog (Drosophila)
YIPF4 Yip1 domain family, member 4
ZC3H7B zinc finger CCCH-type containing 7B
ZNF516 zinc finger protein 516
ZNF528 zinc finger protein 528

decreased expression

Symbol Name
AFAP1 actin filament associated protein 1
ALG12 ALG12, alpha-1,6-mannosyltransferase
ANAPC2 anaphase promoting complex subunit 2
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANP32A-IT1 ANP32A intronic transcript 1
APLP1 amyloid beta (A4) precursor-like protein 1
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BEX4 brain expressed, X-linked 4
BFSP1 beaded filament structural protein 1, filensin
C16ORF62 chromosome 16 open reading frame 62
C4ORF19 chromosome 4 open reading frame 19
C5ORF42 chromosome 5 open reading frame 42
CAMKMT calmodulin-lysine N-methyltransferase
CASS4 Cas scaffolding protein family member 4
CBX4 chromobox homolog 4
CCDC85C coiled-coil domain containing 85C
CDC37L1 cell division cycle 37-like 1
CDK6 cyclin-dependent kinase 6
CDKL3 cyclin-dependent kinase-like 3
CDON cell adhesion associated, oncogene regulated
CENPT centromere protein T
CHM choroideremia (Rab escort protein 1)
CIDEC cell death-inducing DFFA-like effector c
CORO1A coronin, actin binding protein, 1A
CRABP2 cellular retinoic acid binding protein 2
CREB5 cAMP responsive element binding protein 5
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
ERN2 endoplasmic reticulum to nucleus signaling 2
EXOC5 exocyst complex component 5
FAM53B family with sequence similarity 53, member B
FBXL15 F-box and leucine-rich repeat protein 15
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FLT4 fms-related tyrosine kinase 4
FRS2 fibroblast growth factor receptor substrate 2
FUZ fuzzy planar cell polarity protein
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
H1F0 H1 histone family, member 0
HDAC7 histone deacetylase 7
HELZ helicase with zinc finger
HP1BP3 heterochromatin protein 1, binding protein 3
IL36RN interleukin 36 receptor antagonist
INF2 inverted formin, FH2 and WH2 domain containing
INPPL1 inositol polyphosphate phosphatase-like 1
IPO8 importin 8
IRF2BP1 interferon regulatory factor 2 binding protein 1
KLF3 Kruppel-like factor 3 (basic)
KLHL36 kelch-like family member 36
LIG4 ligase IV, DNA, ATP-dependent
LRRC37A4P leucine rich repeat containing 37, member A4, pseudogene
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LY6D lymphocyte antigen 6 complex, locus D
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MFSD6 major facilitator superfamily domain containing 6
MPDU1 mannose-P-dolichol utilization defect 1
MYL9 myosin, light chain 9, regulatory
NABP1 nucleic acid binding protein 1
NBEAL2 neurobeachin-like 2
NUP62CL nucleoporin 62kDa C-terminal like
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PCSK7 proprotein convertase subtilisin/kexin type 7
PKM pyruvate kinase, muscle
PLD3 phospholipase D family, member 3
POLM polymerase (DNA directed), mu
PRR7 proline rich 7 (synaptic)
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
PTPRS protein tyrosine phosphatase, receptor type, S
PWAR5 Prader Willi/Angelman region RNA 5
R3HCC1L R3H domain and coiled-coil containing 1-like
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RNF146 ring finger protein 146
RPGRIP1L RPGRIP1-like
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SPATA1 spermatogenesis associated 1
SSBP3 single stranded DNA binding protein 3
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TINAGL1 tubulointerstitial nephritis antigen-like 1
TLN1 talin 1
TMEM156 transmembrane protein 156
UTRN utrophin
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
YY2 YY2 transcription factor
ZFHX3 zinc finger homeobox 3
ZNF276 zinc finger protein 276
ZNF358 zinc finger protein 358
ZNF778 zinc finger protein 778
ZXDB zinc finger, X-linked, duplicated B