chlortetracycline-2042 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the chlortetracycline-2042 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADORA1 adenosine A1 receptor
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
AIM1L absent in melanoma 1-like
ALOXE3 arachidonate lipoxygenase 3
ANKRD12 ankyrin repeat domain 12
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BIRC7 baculoviral IAP repeat containing 7
BMP2K BMP2 inducible kinase
CACFD1 calcium channel flower domain containing 1
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit
CALB2 calbindin 2
CD82 CD82 molecule
CDHR2 cadherin-related family member 2
CEP41 centrosomal protein 41kDa
CHPF chondroitin polymerizing factor
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CNTFR ciliary neurotrophic factor receptor
COMT catechol-O-methyltransferase
CPM carboxypeptidase M
CPNE7 copine VII
CTRB2 chymotrypsinogen B2
CTRC chymotrypsin C (caldecrin)
CTSS cathepsin S
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DGCR8 DGCR8 microprocessor complex subunit
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DUSP26 dual specificity phosphatase 26 (putative)
EFNB3 ephrin-B3
EFR3B EFR3 homolog B (S. cerevisiae)
EIF1 eukaryotic translation initiation factor 1
ELN elastin
ERN2 endoplasmic reticulum to nucleus signaling 2
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FSCN3 fascin actin-bundling protein 3, testicular
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GIPC1 GIPC PDZ domain containing family, member 1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GNL1 guanine nucleotide binding protein-like 1
GNRH2 gonadotropin-releasing hormone 2
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HNF1A HNF1 homeobox A
HOXB1 homeobox B1
IGHA1 immunoglobulin heavy constant alpha 1
IHH indian hedgehog
IQCC IQ motif containing C
KIF25 kinesin family member 25
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LIMS2 LIM and senescent cell antigen-like domains 2
MFSD11 major facilitator superfamily domain containing 11
MMP25 matrix metallopeptidase 25
MOB3B MOB kinase activator 3B
MRC2 mannose receptor, C type 2
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
NCR2 natural cytotoxicity triggering receptor 2
NPEPL1 aminopeptidase-like 1
NUP214 nucleoporin 214kDa
OR2H2 olfactory receptor, family 2, subfamily H, member 2
PLCG1 phospholipase C, gamma 1
POLR2J4 polymerase (RNA) II (DNA directed) polypeptide J4, pseudogene
POMT2 protein-O-mannosyltransferase 2
PPARA peroxisome proliferator-activated receptor alpha
PRB1 proline-rich protein BstNI subfamily 1
PRB3 proline-rich protein BstNI subfamily 3
PRDM5 PR domain containing 5
PRLH prolactin releasing hormone
PRODH2 proline dehydrogenase (oxidase) 2
PRX periaxin
PSEN2 presenilin 2
PSG7 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)
RAB2A RAB2A, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RANBP3 RAN binding protein 3
RNF39 ring finger protein 39
RPL23AP32 ribosomal protein L23a pseudogene 32
SCN5A sodium channel, voltage gated, type V alpha subunit
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SGSM3 small G protein signaling modulator 3
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SPDEF SAM pointed domain containing ETS transcription factor
STAP2 signal transducing adaptor family member 2
SYN2 synapsin II
TCF3 transcription factor 3
TMCC2 transmembrane and coiled-coil domain family 2
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TNK2 tyrosine kinase, non-receptor, 2
TNNT2 troponin T type 2 (cardiac)
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UBQLN4 ubiquilin 4
UBTD1 ubiquitin domain containing 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VGF VGF nerve growth factor inducible
WIZ widely interspaced zinc finger motifs
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
ZC3H7B zinc finger CCCH-type containing 7B

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ACACA acetyl-CoA carboxylase alpha
ADAM15 ADAM metallopeptidase domain 15
ADRM1 adhesion regulating molecule 1
ARL4A ADP-ribosylation factor-like 4A
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa
ASTE1 asteroid homolog 1 (Drosophila)
AVEN apoptosis, caspase activation inhibitor
AXIN1 axin 1
BCL7C B-cell CLL/lymphoma 7C
C10ORF2 chromosome 10 open reading frame 2
CD320 CD320 molecule
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
COMMD9 COMM domain containing 9
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DHRS7B dehydrogenase/reductase (SDR family) member 7B
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8
DPF2 D4, zinc and double PHD fingers family 2
EMC9 ER membrane protein complex subunit 9
ENDOG endonuclease G
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative)
ERCC2 excision repair cross-complementation group 2
FANCF Fanconi anemia, complementation group F
GBAP1 glucosidase, beta, acid pseudogene 1
GOLGA3 golgin A3
GOLM1 golgi membrane protein 1
HIST1H2BE histone cluster 1, H2be
HN1 hematological and neurological expressed 1
HSPA4L heat shock 70kDa protein 4-like
IFITM3 interferon induced transmembrane protein 3
IP6K1 inositol hexakisphosphate kinase 1
JMJD4 jumonji domain containing 4
JOSD1 Josephin domain containing 1
KEAP1 kelch-like ECH-associated protein 1
KLHL21 kelch-like family member 21
LAMP5 lysosomal-associated membrane protein family, member 5
LIG1 ligase I, DNA, ATP-dependent
MAPKBP1 mitogen-activated protein kinase binding protein 1
MPG N-methylpurine-DNA glycosylase
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
MTG1 mitochondrial ribosome-associated GTPase 1
NADSYN1 NAD synthetase 1
NCAPH non-SMC condensin I complex, subunit H
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NEU1 sialidase 1 (lysosomal sialidase)
NRBP1 nuclear receptor binding protein 1
NUP93 nucleoporin 93kDa
NVL nuclear VCP-like
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
ORC3 origin recognition complex, subunit 3
PCSK7 proprotein convertase subtilisin/kexin type 7
PCTP phosphatidylcholine transfer protein
PEMT phosphatidylethanolamine N-methyltransferase
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PISD phosphatidylserine decarboxylase
PKN1 protein kinase N1
POLB polymerase (DNA directed), beta
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae)
POR P450 (cytochrome) oxidoreductase
POU2F1 POU class 2 homeobox 1
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PPP4C protein phosphatase 4, catalytic subunit
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
PTOV1 prostate tumor overexpressed 1
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RAB4B RAB4B, member RAS oncogene family
RABEPK Rab9 effector protein with kelch motifs
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBM10 RNA binding motif protein 10
RHOH ras homolog family member H
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RPUSD2 RNA pseudouridylate synthase domain containing 2
RUVBL2 RuvB-like AAA ATPase 2
S1PR4 sphingosine-1-phosphate receptor 4
SAC3D1 SAC3 domain containing 1
SMG9 SMG9 nonsense mediated mRNA decay factor
SNX6 sorting nexin 6
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STARD3 StAR-related lipid transfer (START) domain containing 3
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TMEM104 transmembrane protein 104
TMEM106C transmembrane protein 106C
TMEM109 transmembrane protein 109
TMEM184B transmembrane protein 184B
TRAPPC12 trafficking protein particle complex 12
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TSSC4 tumor suppressing subtransferable candidate 4
TTC23 tetratricopeptide repeat domain 23
VILL villin-like
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WDR46 WD repeat domain 46
WDR6 WD repeat domain 6
ZC3H12A zinc finger CCCH-type containing 12A
ZC3H3 zinc finger CCCH-type containing 3
ZNF395 zinc finger protein 395