chlorprothixene-6692 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the chlorprothixene-6692 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM8 ADAM metallopeptidase domain 8
AIM1L absent in melanoma 1-like
AKT2 v-akt murine thymoma viral oncogene homolog 2
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
ARC activity-regulated cytoskeleton-associated protein
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF3 activating transcription factor 3
ATN1 atrophin 1
BCR breakpoint cluster region
C1S complement component 1, s subcomponent
C8A complement component 8, alpha polypeptide
C9ORF9 chromosome 9 open reading frame 9
CALR calreticulin
CASS4 Cas scaffolding protein family member 4
CD6 CD6 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLCA2 chloride channel accessory 2
CLCN4 chloride channel, voltage-sensitive 4
CLDN1 claudin 1
CNTN2 contactin 2 (axonal)
COL10A1 collagen, type X, alpha 1
CSF1 colony stimulating factor 1 (macrophage)
CXCL8 chemokine (C-X-C motif) ligand 8
DCX doublecortin
DDIT3 DNA-damage-inducible transcript 3
DNALI1 dynein, axonemal, light intermediate chain 1
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EPB41 erythrocyte membrane protein band 4.1
FABP3 fatty acid binding protein 3, muscle and heart
FAM182B family with sequence similarity 182, member B
FAM212B family with sequence similarity 212, member B
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FRMD4B FERM domain containing 4B
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GLE1 GLE1 RNA export mediator
GRM8 glutamate receptor, metabotropic 8
GTPBP1 GTP binding protein 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST3H3 histone cluster 3, H3
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HYAL1 hyaluronoglucosaminidase 1
IFIH1 interferon induced with helicase C domain 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
JUND jun D proto-oncogene
KCNK13 potassium channel, two pore domain subfamily K, member 13
KLF4 Kruppel-like factor 4 (gut)
KLHL1 kelch-like family member 1
KLK7 kallikrein-related peptidase 7
KRT17 keratin 17, type I
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
LMOD1 leiomodin 1 (smooth muscle)
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MTCP1 mature T-cell proliferation 1
MTMR3 myotubularin related protein 3
MX1 MX dynamin-like GTPase 1
MYH7 myosin, heavy chain 7, cardiac muscle, beta
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NNMT nicotinamide N-methyltransferase
NPR1 natriuretic peptide receptor 1
NRP2 neuropilin 2
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OASL 2'-5'-oligoadenylate synthetase-like
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha
PPARD peroxisome proliferator-activated receptor delta
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRTN3 proteinase 3
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RARG retinoic acid receptor, gamma
RGS12 regulator of G-protein signaling 12
RGS14 regulator of G-protein signaling 14
RGS4 regulator of G-protein signaling 4
RPL3L ribosomal protein L3-like
SAMD4A sterile alpha motif domain containing 4A
SCN1B sodium channel, voltage gated, type I beta subunit
SFTPA2 surfactant protein A2
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SOX10 SRY (sex determining region Y)-box 10
SPO11 SPO11 meiotic protein covalently bound to DSB
SSX1 synovial sarcoma, X breakpoint 1
TEF thyrotrophic embryonic factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNNT3 troponin T type 3 (skeletal, fast)
TP53I11 tumor protein p53 inducible protein 11
TRPM3 transient receptor potential cation channel, subfamily M, member 3
TTC38 tetratricopeptide repeat domain 38
USP29 ubiquitin specific peptidase 29
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZNF280A zinc finger protein 280A
ZNRF4 zinc and ring finger 4

decreased expression

Symbol Name
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
ADA adenosine deaminase
ADAT1 adenosine deaminase, tRNA-specific 1
ASAP1-IT1 ASAP1 intronic transcript 1
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BMS1 BMS1 ribosome biogenesis factor
C16ORF59 chromosome 16 open reading frame 59
CCDC106 coiled-coil domain containing 106
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CEP131 centrosomal protein 131kDa
CFD complement factor D (adipsin)
COCH cochlin
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
CUL9 cullin 9
CXORF56 chromosome X open reading frame 56
DENND4A DENN/MADD domain containing 4A
ELOVL4 ELOVL fatty acid elongase 4
EXO1 exonuclease 1
FAM184A family with sequence similarity 184, member A
FKBP1B FK506 binding protein 1B, 12.6 kDa
GID4 GID complex subunit 4
GPR3 G protein-coupled receptor 3
GRAMD1C GRAM domain containing 1C
HAUS3 HAUS augmin-like complex, subunit 3
HEATR3 HEAT repeat containing 3
HIRA histone cell cycle regulator
HIST1H1E histone cluster 1, H1e
HIST2H2AA3 histone cluster 2, H2aa3
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXA1 homeobox A1
HSPA1L heat shock 70kDa protein 1-like
IFT22 intraflagellar transport 22
IKZF5 IKAROS family zinc finger 5 (Pegasus)
INCENP inner centromere protein antigens 135/155kDa
INF2 inverted formin, FH2 and WH2 domain containing
IQCG IQ motif containing G
KATNBL1 katanin p80 subunit B-like 1
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KDM4D lysine (K)-specific demethylase 4D
KIAA1107 KIAA1107
KIAA1456 KIAA1456
KIF3A kinesin family member 3A
KLHL3 kelch-like family member 3
LINC00341 long intergenic non-protein coding RNA 341
LINC00597 long intergenic non-protein coding RNA 597
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRRC6 leucine rich repeat containing 6
LRRK1 leucine-rich repeat kinase 1
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LYPLA2P1 lysophospholipase II pseudogene 1
MAGOHB mago-nashi homolog B (Drosophila)
MBTD1 mbt domain containing 1
MELK maternal embryonic leucine zipper kinase
MFSD12 major facilitator superfamily domain containing 12
MGC12488
MOB3B MOB kinase activator 3B
MRPL52 mitochondrial ribosomal protein L52
MTA2 metastasis associated 1 family, member 2
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MXD3 MAX dimerization protein 3
NDP Norrie disease (pseudoglioma)
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NSUN6 NOP2/Sun domain family, member 6
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
ORC1 origin recognition complex, subunit 1
PALMD palmdelphin
PDE8B phosphodiesterase 8B
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
POLE polymerase (DNA directed), epsilon, catalytic subunit
PRF1 perforin 1 (pore forming protein)
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PROS1 protein S (alpha)
RAD51AP1 RAD51 associated protein 1
RECQL4 RecQ protein-like 4
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SIRT6 sirtuin 6
SIX1 SIX homeobox 1
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC35F6 solute carrier family 35, member F6
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
TCTN1 tectonic family member 1
TMEM168 transmembrane protein 168
TMEM212 transmembrane protein 212
TMEM53 transmembrane protein 53
TRAPPC13 trafficking protein particle complex 13
UNC119 unc-119 homolog (C. elegans)
UNKL unkempt family zinc finger-like
WDR62 WD repeat domain 62
XPA xeroderma pigmentosum, complementation group A
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF107 zinc finger protein 107
ZNF215 zinc finger protein 215
ZNF253 zinc finger protein 253
ZNF721 zinc finger protein 721
ZNF770 zinc finger protein 770
ZNF85 zinc finger protein 85