chlorpromazine-6977 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the chlorpromazine-6977 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCY9 adenylate cyclase 9
ADTRP androgen-dependent TFPI-regulating protein
AMPD1 adenosine monophosphate deaminase 1
ANXA2P3 annexin A2 pseudogene 3
APOM apolipoprotein M
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
ASTN2 astrotactin 2
BMP2K BMP2 inducible kinase
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
BST2 bone marrow stromal cell antigen 2
C2ORF54 chromosome 2 open reading frame 54
C5AR2 complement component 5a receptor 2
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCL21 chemokine (C-C motif) ligand 21
CD44 CD44 molecule (Indian blood group)
CD58 CD58 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
CEP164 centrosomal protein 164kDa
CHRM3 cholinergic receptor, muscarinic 3
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DHODH dihydroorotate dehydrogenase (quinone)
DRICH1 aspartate-rich 1
EFNA3 ephrin-A3
ELAVL3 ELAV like neuron-specific RNA binding protein 3
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ESR1 estrogen receptor 1
FER fer (fps/fes related) tyrosine kinase
FGL1 fibrinogen-like 1
FLOT1 flotillin 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GK glycerol kinase
GM2A GM2 ganglioside activator
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPC1 glypican 1
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
ISG20 interferon stimulated exonuclease gene 20kDa
ITM2C integral membrane protein 2C
ITPKB inositol-trisphosphate 3-kinase B
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
LONP2 lon peptidase 2, peroxisomal
MAPK14 mitogen-activated protein kinase 14
MAST4 microtubule associated serine/threonine kinase family member 4
MKL1 megakaryoblastic leukemia (translocation) 1
MMP19 matrix metallopeptidase 19
MSI1 musashi RNA-binding protein 1
MSMB microseminoprotein, beta-
NCAPH2 non-SMC condensin II complex, subunit H2
NEBL nebulette
NFIB nuclear factor I/B
NKX3-2 NK3 homeobox 2
ONECUT2 one cut homeobox 2
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PAQR6 progestin and adipoQ receptor family member VI
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PHF14 PHD finger protein 14
PIDD1 p53-induced death domain protein 1
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PMFBP1 polyamine modulated factor 1 binding protein 1
POPDC3 popeye domain containing 3
PPAP2B phosphatidic acid phosphatase type 2B
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F
PTPN21 protein tyrosine phosphatase, non-receptor type 21
PTPRE protein tyrosine phosphatase, receptor type, E
QKI QKI, KH domain containing, RNA binding
RAB3B RAB3B, member RAS oncogene family
RBM34 RNA binding motif protein 34
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCG2 secretogranin II
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SNX13 sorting nexin 13
SPATA5L1 spermatogenesis associated 5-like 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STX1A syntaxin 1A (brain)
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TMEM53 transmembrane protein 53
TMOD1 tropomodulin 1
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TTC33 tetratricopeptide repeat domain 33
TTLL3 tubulin tyrosine ligase-like family member 3
TUBA3C tubulin, alpha 3c
UNC5B unc-5 homolog B (C. elegans)
VAX2 ventral anterior homeobox 2
VEGFB vascular endothelial growth factor B
WNT16 wingless-type MMTV integration site family, member 16
ZC3H7B zinc finger CCCH-type containing 7B
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF37BP zinc finger protein 37B, pseudogene
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATF3 activating transcription factor 3
ATF7IP2 activating transcription factor 7 interacting protein 2
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BCOR BCL6 corepressor
BTF3P12 basic transcription factor 3 pseudogene 12
C10ORF88 chromosome 10 open reading frame 88
C5 complement component 5
C9ORF91 chromosome 9 open reading frame 91
CCDC85C coiled-coil domain containing 85C
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CEP97 centrosomal protein 97kDa
CISH cytokine inducible SH2-containing protein
CLASRP CLK4-associating serine/arginine rich protein
CLEC16A C-type lectin domain family 16, member A
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRYL1 crystallin, lambda 1
CXORF56 chromosome X open reading frame 56
DEAF1 DEAF1 transcription factor
DENND4C DENN/MADD domain containing 4C
DSCAM Down syndrome cell adhesion molecule
DVL1 dishevelled segment polarity protein 1
ELMO3 engulfment and cell motility 3
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EPB41L5 erythrocyte membrane protein band 4.1 like 5
EPN3 epsin 3
ERCC5 excision repair cross-complementation group 5
FAM118A family with sequence similarity 118, member A
FAM63A family with sequence similarity 63, member A
FDXR ferredoxin reductase
FKBP10 FK506 binding protein 10, 65 kDa
FOSL1 FOS-like antigen 1
FRAT1 frequently rearranged in advanced T-cell lymphomas 1
GATA6 GATA binding protein 6
GHR growth hormone receptor
GLB1L2 galactosidase, beta 1-like 2
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HCFC2 host cell factor C2
HIST1H1D histone cluster 1, H1d
HIST1H4J histone cluster 1, H4j
HMHA1 histocompatibility (minor) HA-1
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IP6K1 inositol hexakisphosphate kinase 1
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
JMJD4 jumonji domain containing 4
KAT2A K(lysine) acetyltransferase 2A
KIF18A kinesin family member 18A
KIZ kizuna centrosomal protein
LIN7A lin-7 homolog A (C. elegans)
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAPK12 mitogen-activated protein kinase 12
METTL16 methyltransferase like 16
MFSD11 major facilitator superfamily domain containing 11
MYO1E myosin IE
NDRG1 N-myc downstream regulated 1
NELFE negative elongation factor complex member E
NES nestin
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDLIM2 PDZ and LIM domain 2 (mystique)
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PTK6 protein tyrosine kinase 6
PTPN9 protein tyrosine phosphatase, non-receptor type 9
PTTG3P pituitary tumor-transforming 3, pseudogene
RAD9A RAD9 homolog A (S. pombe)
RBM23 RNA binding motif protein 23
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RIPK4 receptor-interacting serine-threonine kinase 4
RNF123 ring finger protein 123
RNF126P1 ring finger protein 126 pseudogene 1
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
SCAMP4 secretory carrier membrane protein 4
SMG9 SMG9 nonsense mediated mRNA decay factor
SP1 Sp1 transcription factor
STAG3 stromal antigen 3
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TCTN2 tectonic family member 2
TMEM159 transmembrane protein 159
TRAF2 TNF receptor-associated factor 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIM25 tripartite motif containing 25
URM1 ubiquitin related modifier 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
WDR62 WD repeat domain 62
WDR91 WD repeat domain 91
ZBTB38 zinc finger and BTB domain containing 38
ZNF211 zinc finger protein 211
ZNF23 zinc finger protein 23
ZNF350 zinc finger protein 350
ZNF468 zinc finger protein 468
ZNF552 zinc finger protein 552
ZNF668 zinc finger protein 668
ZNHIT2 zinc finger, HIT-type containing 2