chlorpromazine-6936 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the chlorpromazine-6936 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABI2 abl-interactor 2
ACSF2 acyl-CoA synthetase family member 2
ACTL8 actin-like 8
AKR1C1 aldo-keto reductase family 1, member C1
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
AQP3 aquaporin 3 (Gill blood group)
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATN1 atrophin 1
AUTS2 autism susceptibility candidate 2
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BBS9 Bardet-Biedl syndrome 9
BLVRA biliverdin reductase A
BTD biotinidase
C18ORF25 chromosome 18 open reading frame 25
CCDC92 coiled-coil domain containing 92
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CIDEC cell death-inducing DFFA-like effector c
CLSTN3 calsyntenin 3
CNGB3 cyclic nucleotide gated channel beta 3
COL5A2 collagen, type V, alpha 2
COPA coatomer protein complex, subunit alpha
CPE carboxypeptidase E
CRYBG3 beta-gamma crystallin domain containing 3
CRYGC crystallin, gamma C
CSPP1 centrosome and spindle pole associated protein 1
CTBS chitobiase, di-N-acetyl-
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
EDNRA endothelin receptor type A
EHD2 EH-domain containing 2
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
FECH ferrochelatase
FGFR4 fibroblast growth factor receptor 4
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GLI3 GLI family zinc finger 3
GPM6A glycoprotein M6A
GSPT2 G1 to S phase transition 2
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa
HABP4 hyaluronan binding protein 4
HAUS5 HAUS augmin-like complex, subunit 5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
INPP5J inositol polyphosphate-5-phosphatase J
INSR insulin receptor
KDM4B lysine (K)-specific demethylase 4B
LINC01587 long intergenic non-protein coding RNA 1587
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAN1A1 mannosidase, alpha, class 1A, member 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
NDE1 nudE neurodevelopment protein 1
NDRG2 NDRG family member 2
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
ORAI2 ORAI calcium release-activated calcium modulator 2
PCDHB3 protocadherin beta 3
PEX10 peroxisomal biogenesis factor 10
PTBP3 polypyrimidine tract binding protein 3
PVR poliovirus receptor
RGS10 regulator of G-protein signaling 10
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNF19B ring finger protein 19B
RPS3A ribosomal protein S3A
RUNX1 runt-related transcription factor 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SIX2 SIX homeobox 2
SLCO4C1 solute carrier organic anion transporter family, member 4C1
SPTBN1 spectrin, beta, non-erythrocytic 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SUMO1 small ubiquitin-like modifier 1
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TACC1 transforming, acidic coiled-coil containing protein 1
THOC5 THO complex 5
TLE4 transducin-like enhancer of split 4
TMEM63A transmembrane protein 63A
UBE3A ubiquitin protein ligase E3A
URI1 URI1, prefoldin-like chaperone
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VPS9D1 VPS9 domain containing 1
WDR62 WD repeat domain 62
YLPM1 YLP motif containing 1
ZBTB39 zinc finger and BTB domain containing 39
ZC3H7B zinc finger CCCH-type containing 7B
ZHX3 zinc fingers and homeoboxes 3
ZNF141 zinc finger protein 141
ZNF419 zinc finger protein 419
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
AEN apoptosis enhancing nuclease
AKIP1 A kinase (PRKA) interacting protein 1
ANKEF1 ankyrin repeat and EF-hand domain containing 1
ARL15 ADP-ribosylation factor-like 15
ATF3 activating transcription factor 3
BBS10 Bardet-Biedl syndrome 10
BCOR BCL6 corepressor
BPGM 2,3-bisphosphoglycerate mutase
CAMKMT calmodulin-lysine N-methyltransferase
CAPN5 calpain 5
CCDC176 coiled-coil domain containing 176
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CDC37L1 cell division cycle 37-like 1
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CGREF1 cell growth regulator with EF-hand domain 1
CIR1 corepressor interacting with RBPJ, 1
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
COCH cochlin
CRELD1 cysteine-rich with EGF-like domains 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DNAL4 dynein, axonemal, light chain 4
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
EDC3 enhancer of mRNA decapping 3
EXOC5 exocyst complex component 5
EYA2 EYA transcriptional coactivator and phosphatase 2
FANCC Fanconi anemia, complementation group C
FANCE Fanconi anemia, complementation group E
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
FURIN furin (paired basic amino acid cleaving enzyme)
GDAP2 ganglioside induced differentiation associated protein 2
GMIP GEM interacting protein
GPR19 G protein-coupled receptor 19
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HIST1H3B histone cluster 1, H3b
HMOX1 heme oxygenase 1
IFT81 intraflagellar transport 81
INSIG2 insulin induced gene 2
IRAK4 interleukin-1 receptor-associated kinase 4
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KIAA0894 KIAA0894 protein
KLF3 Kruppel-like factor 3 (basic)
LY6D lymphocyte antigen 6 complex, locus D
LYRM9 LYR motif containing 9
MAN2C1 mannosidase, alpha, class 2C, member 1
MAP1S microtubule-associated protein 1S
MBIP MAP3K12 binding inhibitory protein 1
MED24 mediator complex subunit 24
METTL4 methyltransferase like 4
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
MTRF1 mitochondrial translational release factor 1
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NDRG4 NDRG family member 4
NES nestin
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OTUD3 OTU deubiquitinase 3
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PGPEP1 pyroglutamyl-peptidase I
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PODXL podocalyxin-like
PODXL2 podocalyxin-like 2
POLH polymerase (DNA directed), eta
PROCR protein C receptor, endothelial
PRODH proline dehydrogenase (oxidase) 1
RAB8B RAB8B, member RAS oncogene family
RANBP17 RAN binding protein 17
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RBM41 RNA binding motif protein 41
RNF146 ring finger protein 146
RNF216 ring finger protein 216
RUFY2 RUN and FYVE domain containing 2
RWDD2A RWD domain containing 2A
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
STK25 serine/threonine kinase 25
SYBU syntabulin (syntaxin-interacting)
TBC1D17 TBC1 domain family, member 17
TCTN2 tectonic family member 2
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TNS2 tensin 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIM52 tripartite motif containing 52
TTC4 tetratricopeptide repeat domain 4
TUBA3C tubulin, alpha 3c
TUBA3D tubulin, alpha 3d
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
VGF VGF nerve growth factor inducible
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
ZBTB22 zinc finger and BTB domain containing 22
ZFHX3 zinc finger homeobox 3
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF219 zinc finger protein 219