chlorpromazine-426 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the chlorpromazine-426 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACACA acetyl-CoA carboxylase alpha
ADAM12 ADAM metallopeptidase domain 12
ADORA2B adenosine A2b receptor
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
APOOL apolipoprotein O-like
APP amyloid beta (A4) precursor protein
ARMC7 armadillo repeat containing 7
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASCL1 achaete-scute family bHLH transcription factor 1
ATXN2 ataxin 2
BMPR1A bone morphogenetic protein receptor, type IA
C14ORF79 chromosome 14 open reading frame 79
CAPN7 calpain 7
CD44 CD44 molecule (Indian blood group)
CDC25C cell division cycle 25C
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CLCN7 chloride channel, voltage-sensitive 7
CNTD2 cyclin N-terminal domain containing 2
CREB3 cAMP responsive element binding protein 3
CROT carnitine O-octanoyltransferase
CTTN cortactin
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1
DCLRE1C DNA cross-link repair 1C
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
DENND5A DENN/MADD domain containing 5A
DHFR dihydrofolate reductase
DLEC1 deleted in lung and esophageal cancer 1
DXO decapping exoribonuclease
EFNA1 ephrin-A1
ENOX2 ecto-NOX disulfide-thiol exchanger 2
EPM2AIP1 EPM2A (laforin) interacting protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM134B family with sequence similarity 134, member B
FAM3A family with sequence similarity 3, member A
FKBP1A FK506 binding protein 1A, 12kDa
FKBP2 FK506 binding protein 2, 13kDa
FOXO1 forkhead box O1
GABPB1 GA binding protein transcription factor, beta subunit 1
GRK6 G protein-coupled receptor kinase 6
HMGXB3 HMG box domain containing 3
HRG histidine-rich glycoprotein
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IL11 interleukin 11
IRAK4 interleukin-1 receptor-associated kinase 4
JAKMIP2 janus kinase and microtubule interacting protein 2
KCTD2 potassium channel tetramerization domain containing 2
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KLHL28 kelch-like family member 28
LMO3 LIM domain only 3 (rhombotin-like 2)
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MCAM melanoma cell adhesion molecule
MED13L mediator complex subunit 13-like
MRPS31 mitochondrial ribosomal protein S31
N4BP2L2 NEDD4 binding protein 2-like 2
NDC80 NDC80 kinetochore complex component
NUCB2 nucleobindin 2
PEX11A peroxisomal biogenesis factor 11 alpha
PI4KB phosphatidylinositol 4-kinase, catalytic, beta
PKNOX1 PBX/knotted 1 homeobox 1
PMEPA1 prostate transmembrane protein, androgen induced 1
PNPLA6 patatin-like phospholipase domain containing 6
POLG polymerase (DNA directed), gamma
PQLC1 PQ loop repeat containing 1
PRDM14 PR domain containing 14
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RBL2 retinoblastoma-like 2
RBM5 RNA binding motif protein 5
RBM8A RNA binding motif protein 8A
RPS2 ribosomal protein S2
RRAS related RAS viral (r-ras) oncogene homolog
RSAD1 radical S-adenosyl methionine domain containing 1
SH2D1A SH2 domain containing 1A
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC17A4 solute carrier family 17, member 4
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SPTBN5 spectrin, beta, non-erythrocytic 5
STX5 syntaxin 5
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae)
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM242 transmembrane protein 242
TMEM39A transmembrane protein 39A
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8
TNIK TRAF2 and NCK interacting kinase
TRIM8 tripartite motif containing 8
TTLL4 tubulin tyrosine ligase-like family member 4
TXN thioredoxin
VPS33B vacuolar protein sorting 33 homolog B (yeast)
WWOX WW domain containing oxidoreductase
YIPF6 Yip1 domain family, member 6
YLPM1 YLP motif containing 1
YY1AP1 YY1 associated protein 1
ZC3H12A zinc finger CCCH-type containing 12A
ZNF154 zinc finger protein 154
ZNF710 zinc finger protein 710

decreased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ADAM15 ADAM metallopeptidase domain 15
ADAM23 ADAM metallopeptidase domain 23
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ARRB1 arrestin, beta 1
ARSA arylsulfatase A
ARSF arylsulfatase F
AURKC aurora kinase C
BCL2L14 BCL2-like 14 (apoptosis facilitator)
BHMT betaine--homocysteine S-methyltransferase
C16ORF62 chromosome 16 open reading frame 62
CA5A carbonic anhydrase VA, mitochondrial
CA7 carbonic anhydrase VII
CAPG capping protein (actin filament), gelsolin-like
CCDC33 coiled-coil domain containing 33
CCP110 centriolar coiled coil protein 110kDa
CD82 CD82 molecule
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK9 cyclin-dependent kinase 9
CFAP70 cilia and flagella associated protein 70
CHD2 chromodomain helicase DNA binding protein 2
CHRM4 cholinergic receptor, muscarinic 4
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CLCN6 chloride channel, voltage-sensitive 6
CLEC10A C-type lectin domain family 10, member A
CNR2 cannabinoid receptor 2 (macrophage)
CNTFR ciliary neurotrophic factor receptor
COLGALT2 collagen beta(1-O)galactosyltransferase 2
DENND4B DENN/MADD domain containing 4B
DENND4C DENN/MADD domain containing 4C
DSCAM Down syndrome cell adhesion molecule
EFCAB1 EF-hand calcium binding domain 1
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ERN2 endoplasmic reticulum to nucleus signaling 2
EXD3 exonuclease 3'-5' domain containing 3
FAM46C family with sequence similarity 46, member C
FSCN3 fascin actin-bundling protein 3, testicular
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GPR182 G protein-coupled receptor 182
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIP2 glutamate receptor interacting protein 2
HOXA4 homeobox A4
HP haptoglobin
HPN hepsin
IRF9 interferon regulatory factor 9
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14
KIAA0509 uncharacterized LOC57242
LARS leucyl-tRNA synthetase
LENEP lens epithelial protein
LGALS13 lectin, galactoside-binding, soluble, 13
LRP5 low density lipoprotein receptor-related protein 5
MAPK3 mitogen-activated protein kinase 3
MLYCD malonyl-CoA decarboxylase
MMP3 matrix metallopeptidase 3
MTMR10 myotubularin related protein 10
MUC2 mucin 2, oligomeric mucus/gel-forming
NDRG4 NDRG family member 4
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OR1G1 olfactory receptor, family 1, subfamily G, member 1
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
OVOL1 ovo-like zinc finger 1
PARG poly (ADP-ribose) glycohydrolase
PCDHB6 protocadherin beta 6
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHC1 polyhomeotic homolog 1 (Drosophila)
POMT1 protein-O-mannosyltransferase 1
POU4F2 POU class 4 homeobox 2
PRICKLE3 prickle homolog 3 (Drosophila)
PTPRT protein tyrosine phosphatase, receptor type, T
QTRT1 queuine tRNA-ribosyltransferase 1
RAP1GAP2 RAP1 GTPase activating protein 2
RASAL1 RAS protein activator like 1 (GAP1 like)
REM1 RAS (RAD and GEM)-like GTP-binding 1
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
S100A1 S100 calcium binding protein A1
SCIN scinderin
SIL1 SIL1 nucleotide exchange factor
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1
SMA4 glucuronidase, beta pseudogene
STAC SH3 and cysteine rich domain
TBR1 T-box, brain, 1
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TGM5 transglutaminase 5
TLN1 talin 1
TMPRSS5 transmembrane protease, serine 5
TP53TG5 TP53 target 5
TRAF2 TNF receptor-associated factor 2
TRAV8-3 T cell receptor alpha variable 8-3
TYR tyrosinase
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZFR2 zinc finger RNA binding protein 2
ZNF586 zinc finger protein 586