chloroquine-7251 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the chloroquine-7251 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AASS aminoadipate-semialdehyde synthase
ADAM11 ADAM metallopeptidase domain 11
AK1 adenylate kinase 1
AKAP10 A kinase (PRKA) anchor protein 10
ANXA10 annexin A10
APOL6 apolipoprotein L, 6
APOLD1 apolipoprotein L domain containing 1
ARRB2 arrestin, beta 2
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCR breakpoint cluster region
C11ORF30 chromosome 11 open reading frame 30
C14ORF105 chromosome 14 open reading frame 105
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CEP68 centrosomal protein 68kDa
CPNE7 copine VII
DLK2 delta-like 2 homolog (Drosophila)
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8
DOCK10 dedicator of cytokinesis 10
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPB41L1 erythrocyte membrane protein band 4.1-like 1
ERCC1 excision repair cross-complementation group 1
FAM69A family with sequence similarity 69, member A
FGD1 FYVE, RhoGEF and PH domain containing 1
FGF13 fibroblast growth factor 13
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FXR2 fragile X mental retardation, autosomal homolog 2
GAREM GRB2 associated, regulator of MAPK1
HOXA4 homeobox A4
HOXC10 homeobox C10
HSPB6 heat shock protein, alpha-crystallin-related, B6
IFIH1 interferon induced with helicase C domain 1
IQCC IQ motif containing C
IRF2BP1 interferon regulatory factor 2 binding protein 1
IRF6 interferon regulatory factor 6
IRS2 insulin receptor substrate 2
JUNB jun B proto-oncogene
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KIF2A kinesin heavy chain member 2A
KIFC3 kinesin family member C3
MAN1B1 mannosidase, alpha, class 1B, member 1
MAOA monoamine oxidase A
MAPK7 mitogen-activated protein kinase 7
MBTD1 mbt domain containing 1
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MKL1 megakaryoblastic leukemia (translocation) 1
MOCS3 molybdenum cofactor synthesis 3
MXD4 MAX dimerization protein 4
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYRF myelin regulatory factor
NCOA3 nuclear receptor coactivator 3
NID1 nidogen 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
OAZ3 ornithine decarboxylase antizyme 3
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PCSK6 proprotein convertase subtilisin/kexin type 6
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PDLIM7 PDZ and LIM domain 7 (enigma)
PIDD1 p53-induced death domain protein 1
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
POLL polymerase (DNA directed), lambda
PPT2 palmitoyl-protein thioesterase 2
PTGES prostaglandin E synthase
PVR poliovirus receptor
RARA retinoic acid receptor, alpha
RNF19B ring finger protein 19B
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
RUSC2 RUN and SH3 domain containing 2
SATB2 SATB homeobox 2
SBF1 SET binding factor 1
SBNO2 strawberry notch homolog 2 (Drosophila)
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SERTAD3 SERTA domain containing 3
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SH3D21 SH3 domain containing 21
SIRT3 sirtuin 3
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SRD5A3 steroid 5 alpha-reductase 3
SS18 synovial sarcoma translocation, chromosome 18
SSX1 synovial sarcoma, X breakpoint 1
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STYK1 serine/threonine/tyrosine kinase 1
TAZ tafazzin
TBXAS1 thromboxane A synthase 1 (platelet)
TEX40 testis expressed 40
THOC5 THO complex 5
TJAP1 tight junction associated protein 1 (peripheral)
TNC tenascin C
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TRIM23 tripartite motif containing 23
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TUBA3C tubulin, alpha 3c
WNT7A wingless-type MMTV integration site family, member 7A
ZNF79 zinc finger protein 79

decreased expression

Symbol Name
ABHD4 abhydrolase domain containing 4
ABHD8 abhydrolase domain containing 8
ADGRF1 adhesion G protein-coupled receptor F1
ARMC6 armadillo repeat containing 6
C11ORF71 chromosome 11 open reading frame 71
C11ORF80 chromosome 11 open reading frame 80
C5ORF28 chromosome 5 open reading frame 28
C7ORF43 chromosome 7 open reading frame 43
C8ORF60 chromosome 8 open reading frame 60
CCDC176 coiled-coil domain containing 176
CCS copper chaperone for superoxide dismutase
CLIP4 CAP-GLY domain containing linker protein family, member 4
CNKSR1 connector enhancer of kinase suppressor of Ras 1
COCH cochlin
CTNNBL1 catenin, beta like 1
DBF4B DBF4 zinc finger B
DPY19L2P2 DPY19L2 pseudogene 2
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EN1 engrailed homeobox 1
EPHA4 EPH receptor A4
ERCC5 excision repair cross-complementation group 5
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM193B family with sequence similarity 193, member B
FBP1 fructose-1,6-bisphosphatase 1
FBXO3 F-box protein 3
FIP1L1 factor interacting with PAPOLA and CPSF1
FOXA1 forkhead box A1
GAB2 GRB2-associated binding protein 2
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GLCE glucuronic acid epimerase
GPATCH1 G patch domain containing 1
GTPBP6 GTP binding protein 6 (putative)
HOXC8 homeobox C8
IL7R interleukin 7 receptor
ISL1 ISL LIM homeobox 1
JMJD4 jumonji domain containing 4
KCTD9 potassium channel tetramerization domain containing 9
KIF13B kinesin family member 13B
KIRREL kin of IRRE like (Drosophila)
KRT75 keratin 75, type II
MANSC1 MANSC domain containing 1
MAPK3 mitogen-activated protein kinase 3
METTL2B methyltransferase like 2B
MFF mitochondrial fission factor
MFSD12 major facilitator superfamily domain containing 12
MID1IP1 MID1 interacting protein 1
MIR22HG MIR22 host gene
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
MPST mercaptopyruvate sulfurtransferase
MST1R macrophage stimulating 1 receptor
MTRF1 mitochondrial translational release factor 1
MYO19 myosin XIX
NDE1 nudE neurodevelopment protein 1
NLK nemo-like kinase
OLFML2A olfactomedin-like 2A
ORAI3 ORAI calcium release-activated calcium modulator 3
ORC1 origin recognition complex, subunit 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PILRB paired immunoglobin-like type 2 receptor beta
PLEKHJ1 pleckstrin homology domain containing, family J member 1
POLI polymerase (DNA directed) iota
PSENEN presenilin enhancer gamma secretase subunit
RBBP5 retinoblastoma binding protein 5
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF31 ring finger protein 31
RPGR retinitis pigmentosa GTPase regulator
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC25A40 solute carrier family 25, member 40
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SOBP sine oculis binding protein homolog (Drosophila)
STBD1 starch binding domain 1
STK25 serine/threonine kinase 25
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TBC1D17 TBC1 domain family, member 17
TIGD6 tigger transposable element derived 6
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TMEM120B transmembrane protein 120B
TMEM177 transmembrane protein 177
TMEM209 transmembrane protein 209
TMEM62 transmembrane protein 62
TPCN1 two pore segment channel 1
TRIM21 tripartite motif containing 21
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TTC23 tetratricopeptide repeat domain 23
URGCP upregulator of cell proliferation
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZDHHC13 zinc finger, DHHC-type containing 13
ZNF230 zinc finger protein 230
ZNF304 zinc finger protein 304
ZNF324 zinc finger protein 324
ZNF574 zinc finger protein 574
ZNF629 zinc finger protein 629
ZNF701 zinc finger protein 701
ZNF804A zinc finger protein 804A
ZNF862 zinc finger protein 862