chloroquine-7012 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the chloroquine-7012 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2
ADAP1 ArfGAP with dual PH domains 1
AK1 adenylate kinase 1
ALOX15 arachidonate 15-lipoxygenase
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
BCAN brevican
CALD1 caldesmon 1
CASP4 caspase 4, apoptosis-related cysteine peptidase
CASP5 caspase 5, apoptosis-related cysteine peptidase
CCDC93 coiled-coil domain containing 93
CCPG1 cell cycle progression 1
CEP72 centrosomal protein 72kDa
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
COL8A1 collagen, type VIII, alpha 1
COMT catechol-O-methyltransferase
CREBZF CREB/ATF bZIP transcription factor
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CUL5 cullin 5
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DTNA dystrobrevin, alpha
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
ESR1 estrogen receptor 1
FHL1 four and a half LIM domains 1
FOSL2 FOS-like antigen 2
G0S2 G0/G1 switch 2
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GLTSCR1L GLTSCR1-like
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
HEG1 heart development protein with EGF-like domains 1
HNMT histamine N-methyltransferase
HOXB6 homeobox B6
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGLJ3 immunoglobulin lambda joining 3
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KCNK12 potassium channel, two pore domain subfamily K, member 12
KDM5C lysine (K)-specific demethylase 5C
LHX6 LIM homeobox 6
MAP4 microtubule-associated protein 4
MDM4 MDM4, p53 regulator
MTSS1L metastasis suppressor 1-like
NAG18 NAG18 mRNA
NDRG4 NDRG family member 4
NPIPB15 nuclear pore complex interacting protein family, member B15
NRTN neurturin
ONECUT2 one cut homeobox 2
PACS1 phosphofurin acidic cluster sorting protein 1
PAX5 paired box 5
PDAP1 PDGFA associated protein 1
PDLIM5 PDZ and LIM domain 5
PGR progesterone receptor
PLXNA3 plexin A3
PMS2P2 postmeiotic segregation increased 2 pseudogene 2
POM121 POM121 transmembrane nucleoporin
PPAP2B phosphatidic acid phosphatase type 2B
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PRKD3 protein kinase D3
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RAB30 RAB30, member RAS oncogene family
RCAN3 RCAN family member 3
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS12 regulator of G-protein signaling 12
RNF2 ring finger protein 2
RNF39 ring finger protein 39
RPLP2 ribosomal protein, large, P2
S100A13 S100 calcium binding protein A13
SAMD9 sterile alpha motif domain containing 9
SAP30 Sin3A-associated protein, 30kDa
SCARB2 scavenger receptor class B, member 2
SHOX2 short stature homeobox 2
SOWAHC sosondowah ankyrin repeat domain family member C
SP1 Sp1 transcription factor
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
SUN2 Sad1 and UNC84 domain containing 2
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast)
TMC6 transmembrane channel-like 6
TMEM45A transmembrane protein 45A
TMEM63A transmembrane protein 63A
TMPRSS2 transmembrane protease, serine 2
TPP1 tripeptidyl peptidase I
TRAPPC10 trafficking protein particle complex 10
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TTC9 tetratricopeptide repeat domain 9
TTLL5 tubulin tyrosine ligase-like family member 5
TUBA3C tubulin, alpha 3c
VDAC3 voltage-dependent anion channel 3
WIZ widely interspaced zinc finger motifs
XAF1 XIAP associated factor 1
ZFAND6 zinc finger, AN1-type domain 6
ZNF134 zinc finger protein 134
ZNF318 zinc finger protein 318
ZNF324 zinc finger protein 324
ZNF821 zinc finger protein 821

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AHCTF1 AT hook containing transcription factor 1
AKR1C3 aldo-keto reductase family 1, member C3
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ARHGAP10 Rho GTPase activating protein 10
ARRB2 arrestin, beta 2
ASPHD1 aspartate beta-hydroxylase domain containing 1
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BMP4 bone morphogenetic protein 4
C14ORF132 chromosome 14 open reading frame 132
C16ORF62 chromosome 16 open reading frame 62
C19ORF40 chromosome 19 open reading frame 40
C3ORF52 chromosome 3 open reading frame 52
CAMKMT calmodulin-lysine N-methyltransferase
CAPG capping protein (actin filament), gelsolin-like
CCNT1 cyclin T1
CEP85 centrosomal protein 85kDa
CISH cytokine inducible SH2-containing protein
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
DDIT3 DNA-damage-inducible transcript 3
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DHDDS dehydrodolichyl diphosphate synthase
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DSCAM Down syndrome cell adhesion molecule
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
ECHDC2 enoyl CoA hydratase domain containing 2
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EFNA3 ephrin-A3
ELOVL4 ELOVL fatty acid elongase 4
EML4 echinoderm microtubule associated protein like 4
EPHA2 EPH receptor A2
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ETAA1 Ewing tumor-associated antigen 1
FAM118A family with sequence similarity 118, member A
FAM188A family with sequence similarity 188, member A
FCHO1 FCH domain only 1
FSD1 fibronectin type III and SPRY domain containing 1
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B
GJA1 gap junction protein, alpha 1, 43kDa
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4
HELZ helicase with zinc finger
HIRA histone cell cycle regulator
HIST1H1D histone cluster 1, H1d
HIST1H2AJ histone cluster 1, H2aj
HOXC11 homeobox C11
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
IFITM1 interferon induced transmembrane protein 1
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
IRF7 interferon regulatory factor 7
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KLF3 Kruppel-like factor 3 (basic)
LIN37 lin-37 DREAM MuvB core complex component
LRRC20 leucine rich repeat containing 20
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MED24 mediator complex subunit 24
METTL2B methyltransferase like 2B
MFSD12 major facilitator superfamily domain containing 12
MITF microphthalmia-associated transcription factor
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
MTA2 metastasis associated 1 family, member 2
MTHFSD methenyltetrahydrofolate synthetase domain containing
NARFL nuclear prelamin A recognition factor-like
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PCDHA6 protocadherin alpha 6
PCSK7 proprotein convertase subtilisin/kexin type 7
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLEK2 pleckstrin 2
PTCD2 pentatricopeptide repeat domain 2
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RFTN1 raftlin, lipid raft linker 1
RNF31 ring finger protein 31
RPL13P5 ribosomal protein L13 pseudogene 5
SETD8 SET domain containing (lysine methyltransferase) 8
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SPINK4 serine peptidase inhibitor, Kazal type 4
SYBU syntabulin (syntaxin-interacting)
TDRD1 tudor domain containing 1
TGFB3 transforming growth factor, beta 3
THBS3 thrombospondin 3
TMEM184B transmembrane protein 184B
TMEM185B transmembrane protein 185B
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TSPAN1 tetraspanin 1
TWF2 twinfilin actin binding protein 2
VAV1 vav 1 guanine nucleotide exchange factor
VEGFC vascular endothelial growth factor C
WDR44 WD repeat domain 44
WFS1 Wolfram syndrome 1 (wolframin)
ZBTB10 zinc finger and BTB domain containing 10
ZNF14 zinc finger protein 14
ZNF268 zinc finger protein 268
ZNF668 zinc finger protein 668
ZNF8 zinc finger protein 8
ZNF816 zinc finger protein 816