chloroquine-2869 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the chloroquine-2869 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ALDOB aldolase B, fructose-bisphosphate
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ASIC1 acid sensing (proton gated) ion channel 1
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4
BAHCC1 BAH domain and coiled-coil containing 1
BAIAP3 BAI1-associated protein 3
C15ORF39 chromosome 15 open reading frame 39
C9ORF16 chromosome 9 open reading frame 16
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CD82 CD82 molecule
CDC25C cell division cycle 25C
CDK18 cyclin-dependent kinase 18
CFAP45 cilia and flagella associated protein 45
COL4A6 collagen, type IV, alpha 6
COPA coatomer protein complex, subunit alpha
CREBBP CREB binding protein
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
CTIF CBP80/20-dependent translation initiation factor
CYLD cylindromatosis (turban tumor syndrome)
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DIO2 deiodinase, iodothyronine, type II
DIXDC1 DIX domain containing 1
DOCK10 dedicator of cytokinesis 10
DTNA dystrobrevin, alpha
ELN elastin
FAM105A family with sequence similarity 105, member A
FGD1 FYVE, RhoGEF and PH domain containing 1
FKBP10 FK506 binding protein 10, 65 kDa
FLJ11710 uncharacterized protein FLJ11710
FOXG1 forkhead box G1
GPC1 glypican 1
GPER1 G protein-coupled estrogen receptor 1
GPSM3 G-protein signaling modulator 3
GRM2 glutamate receptor, metabotropic 2
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IFITM1 interferon induced transmembrane protein 1
IL1RAP interleukin 1 receptor accessory protein
IRF9 interferon regulatory factor 9
ITM2C integral membrane protein 2C
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KLHL25 kelch-like family member 25
KRT15 keratin 15, type I
LIMCH1 LIM and calponin homology domains 1
NBL1 neuroblastoma 1, DAN family BMP antagonist
NPC1 Niemann-Pick disease, type C1
NPR1 natriuretic peptide receptor 1
NUP214 nucleoporin 214kDa
PARP12 poly (ADP-ribose) polymerase family, member 12
PBX2 pre-B-cell leukemia homeobox 2
PDLIM5 PDZ and LIM domain 5
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLAGL1 pleiomorphic adenoma gene-like 1
POU4F1 POU class 4 homeobox 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PQLC2 PQ loop repeat containing 2
PRODH proline dehydrogenase (oxidase) 1
PTAFR platelet-activating factor receptor
RAB11FIP3 RAB11 family interacting protein 3 (class II)
RAB6B RAB6B, member RAS oncogene family
RANBP3 RAN binding protein 3
RBM5 RNA binding motif protein 5
RBP4 retinol binding protein 4, plasma
REG1B regenerating islet-derived 1 beta
SAG S-antigen; retina and pineal gland (arrestin)
SDC2 syndecan 2
SIPA1L1 signal-induced proliferation-associated 1 like 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A7 solute carrier family 38, member 7
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SMC1A structural maintenance of chromosomes 1A
SORBS1 sorbin and SH3 domain containing 1
SRCAP Snf2-related CREBBP activator protein
STARD8 StAR-related lipid transfer (START) domain containing 8
STIM1 stromal interaction molecule 1
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae)
SYNC syncoilin, intermediate filament protein
TFEB transcription factor EB
THRB thyroid hormone receptor, beta
TM4SF1 transmembrane 4 L six family member 1
TRIM29 tripartite motif containing 29
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UMPS uridine monophosphate synthetase
USP46 ubiquitin specific peptidase 46
VLDLR very low density lipoprotein receptor
WSCD1 WSC domain containing 1
ZMIZ2 zinc finger, MIZ-type containing 2

decreased expression

Symbol Name
ADAM15 ADAM metallopeptidase domain 15
ARRB1 arrestin, beta 1
ATP7A ATPase, Cu++ transporting, alpha polypeptide
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
C14ORF93 chromosome 14 open reading frame 93
CARD8 caspase recruitment domain family, member 8
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CD8A CD8a molecule
CHPF chondroitin polymerizing factor
DCAF13 DDB1 and CUL4 associated factor 13
DCAF4 DDB1 and CUL4 associated factor 4
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DNALI1 dynein, axonemal, light intermediate chain 1
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ERCC4 excision repair cross-complementation group 4
ERN2 endoplasmic reticulum to nucleus signaling 2
ETV6 ets variant 6
F2R coagulation factor II (thrombin) receptor
FAM189A2 family with sequence similarity 189, member A2
FFAR2 free fatty acid receptor 2
FGF23 fibroblast growth factor 23
FLCN folliculin
FLT4 fms-related tyrosine kinase 4
GRB7 growth factor receptor-bound protein 7
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
GUSBP3 glucuronidase, beta pseudogene 3
HAUS2 HAUS augmin-like complex, subunit 2
HIST1H2AJ histone cluster 1, H2aj
HIST1H3B histone cluster 1, H3b
HIST1H4E histone cluster 1, H4e
HLA-J major histocompatibility complex, class I, J (pseudogene)
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2
HOXC4 homeobox C4
HYI hydroxypyruvate isomerase (putative)
INCENP inner centromere protein antigens 135/155kDa
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITFG2 integrin alpha FG-GAP repeat containing 2
KIAA0894 KIAA0894 protein
KIF13A kinesin family member 13A
LMNB1 lamin B1
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LOC390998 ribosomal protein L10 pseudogene
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MED18 mediator complex subunit 18
MGC12488
MOGS mannosyl-oligosaccharide glucosidase
MPHOSPH8 M-phase phosphoprotein 8
MTA2 metastasis associated 1 family, member 2
MYOZ3 myozenin 3
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NKX3-2 NK3 homeobox 2
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
PACS1 phosphofurin acidic cluster sorting protein 1
PARD6B par-6 family cell polarity regulator beta
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PHC3 polyhomeotic homolog 3 (Drosophila)
POLH polymerase (DNA directed), eta
PTK6 protein tyrosine kinase 6
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RIN2 Ras and Rab interactor 2
RNF2 ring finger protein 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC12A8 solute carrier family 12, member 8
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STAG3L1 stromal antigen 3-like 1 (pseudogene)
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYBU syntabulin (syntaxin-interacting)
TBX19 T-box 19
TDRD1 tudor domain containing 1
TFF2 trefoil factor 2
TH tyrosine hydroxylase
TMEM209 transmembrane protein 209
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
TSPAN5 tetraspanin 5
TTLL1 tubulin tyrosine ligase-like family member 1
TYRP1 tyrosinase-related protein 1
USP36 ubiquitin specific peptidase 36
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XYLT2 xylosyltransferase II
ZBTB33 zinc finger and BTB domain containing 33
ZFHX2 zinc finger homeobox 2
ZNF205 zinc finger protein 205
ZNF350 zinc finger protein 350
ZNF41 zinc finger protein 41
ZNF442 zinc finger protein 442
ZNF587 zinc finger protein 587
ZNF669 zinc finger protein 669