chloropyrazine-3570 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the chloropyrazine-3570 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTA1 actin, alpha 1, skeletal muscle
ADAM22 ADAM metallopeptidase domain 22
AKR1C1 aldo-keto reductase family 1, member C1
ANTXR1 anthrax toxin receptor 1
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
APC adenomatous polyposis coli
APOM apolipoprotein M
AREG amphiregulin
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
C17ORF59 chromosome 17 open reading frame 59
C21ORF2 chromosome 21 open reading frame 2
C3ORF18 chromosome 3 open reading frame 18
C6 complement component 6
CABP2 calcium binding protein 2
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCPG1 cell cycle progression 1
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLCN6 chloride channel, voltage-sensitive 6
CLCN7 chloride channel, voltage-sensitive 7
CRIP1 cysteine-rich protein 1 (intestinal)
CRP C-reactive protein, pentraxin-related
CTBP2 C-terminal binding protein 2
CYBB cytochrome b-245, beta polypeptide
DMXL2 Dmx-like 2
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DPP4 dipeptidyl-peptidase 4
EFR3B EFR3 homolog B (S. cerevisiae)
ELAC2 elaC ribonuclease Z 2
EN2 engrailed homeobox 2
FBLN1 fibulin 1
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FMO5 flavin containing monooxygenase 5
FRMD1 FERM domain containing 1
FUS FUS RNA binding protein
GALC galactosylceramidase
GOSR1 golgi SNAP receptor complex member 1
GRM1 glutamate receptor, metabotropic 1
GSPT1 G1 to S phase transition 1
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
HIP1 huntingtin interacting protein 1
HIST1H1E histone cluster 1, H1e
ICOSLG inducible T-cell co-stimulator ligand
IFI44 interferon-induced protein 44
IL1B interleukin 1, beta
IQCK IQ motif containing K
JAM3 junctional adhesion molecule 3
LRP6 low density lipoprotein receptor-related protein 6
MIOS missing oocyte, meiosis regulator, homolog (Drosophila)
MXD3 MAX dimerization protein 3
NBL1 neuroblastoma 1, DAN family BMP antagonist
NF1 neurofibromin 1
NF2 neurofibromin 2 (merlin)
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUP188 nucleoporin 188kDa
OXCT2 3-oxoacid CoA transferase 2
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PCYT1A phosphate cytidylyltransferase 1, choline, alpha
PITX1 paired-like homeodomain 1
POFUT1 protein O-fucosyltransferase 1
PRMT2 protein arginine methyltransferase 2
PRODH proline dehydrogenase (oxidase) 1
PROSC proline synthetase co-transcribed homolog (bacterial)
PURA purine-rich element binding protein A
QKI QKI, KH domain containing, RNA binding
RIMS3 regulating synaptic membrane exocytosis 3
RNGTT RNA guanylyltransferase and 5'-phosphatase
SAFB scaffold attachment factor B
SAG S-antigen; retina and pineal gland (arrestin)
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SNX13 sorting nexin 13
SOS2 son of sevenless homolog 2 (Drosophila)
SYNJ1 synaptojanin 1
SYNJ2 synaptojanin 2
TAZ tafazzin
TBX2 T-box 2
TEP1 telomerase-associated protein 1
TIMP3 TIMP metallopeptidase inhibitor 3
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TWSG1 twisted gastrulation BMP signaling modulator 1
USP9Y ubiquitin specific peptidase 9, Y-linked
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VAC14 Vac14 homolog (S. cerevisiae)
VIM vimentin
WIPF1 WAS/WASL interacting protein family, member 1
ZC3H7B zinc finger CCCH-type containing 7B
ZFAND5 zinc finger, AN1-type domain 5
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF442 zinc finger protein 442
ZNF639 zinc finger protein 639
ZNF821 zinc finger protein 821
ZSWIM1 zinc finger, SWIM-type containing 1

decreased expression

Symbol Name
ABI3BP ABI family, member 3 (NESH) binding protein
ACAD10 acyl-CoA dehydrogenase family, member 10
ACTL8 actin-like 8
ADGRE5 adhesion G protein-coupled receptor E5
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARRB1 arrestin, beta 1
ATP13A2 ATPase type 13A2
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4
AXIN1 axin 1
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BATF basic leucine zipper transcription factor, ATF-like
C11ORF63 chromosome 11 open reading frame 63
C11ORF68 chromosome 11 open reading frame 68
CCDC69 coiled-coil domain containing 69
CCDC88C coiled-coil domain containing 88C
CD82 CD82 molecule
CD83 CD83 molecule
CEMIP cell migration inducing protein, hyaluronan binding
CEP170B centrosomal protein 170B
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CLCF1 cardiotrophin-like cytokine factor 1
CORO1A coronin, actin binding protein, 1A
CPPED1 calcineurin-like phosphoesterase domain containing 1
DDIT3 DNA-damage-inducible transcript 3
DUSP2 dual specificity phosphatase 2
EMID1 EMI domain containing 1
EPYC epiphycan
EVPL envoplakin
FBRS fibrosin
FBXL7 F-box and leucine-rich repeat protein 7
FOSL1 FOS-like antigen 1
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
GAB2 GRB2-associated binding protein 2
GADD45G growth arrest and DNA-damage-inducible, gamma
GEMIN8 gem (nuclear organelle) associated protein 8
GPR176 G protein-coupled receptor 176
HIST1H4F histone cluster 1, H4f
IFT140 intraflagellar transport 140
IRF9 interferon regulatory factor 9
KDM5C lysine (K)-specific demethylase 5C
KIAA0319L KIAA0319-like
KIF13B kinesin family member 13B
KLHL12 kelch-like family member 12
LAMA5 laminin, alpha 5
LAMB3 laminin, beta 3
LHX1 LIM homeobox 1
LIG4 ligase IV, DNA, ATP-dependent
LOC390998 ribosomal protein L10 pseudogene
LRRC20 leucine rich repeat containing 20
LY6D lymphocyte antigen 6 complex, locus D
LZTR1 leucine-zipper-like transcription regulator 1
MTHFSD methenyltetrahydrofolate synthetase domain containing
N4BP3 NEDD4 binding protein 3
NACA2 nascent polypeptide-associated complex alpha subunit 2
NLGN1 neuroligin 1
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PDE8B phosphodiesterase 8B
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PKN1 protein kinase N1
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLXNA3 plexin A3
PTPRE protein tyrosine phosphatase, receptor type, E
RAB4B RAB4B, member RAS oncogene family
RAB5B RAB5B, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPS21 ribosomal protein S21
RUNDC3B RUN domain containing 3B
SCD5 stearoyl-CoA desaturase 5
SCUBE3 signal peptide, CUB domain, EGF-like 3
SERGEF secretion regulating guanine nucleotide exchange factor
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SIRT6 sirtuin 6
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TDRD1 tudor domain containing 1
TMEM120B transmembrane protein 120B
TRIM25 tripartite motif containing 25
TWF2 twinfilin actin binding protein 2
USP19 ubiquitin specific peptidase 19
VASH2 vasohibin 2
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF10 zinc finger protein 10
ZNF137P zinc finger protein 137, pseudogene
ZNF227 zinc finger protein 227
ZNF280D zinc finger protein 280D
ZNF286A zinc finger protein 286A