chlorcyclizine-3893 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the chlorcyclizine-3893 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADRA1D adrenoceptor alpha 1D
ALLC allantoicase
ARC activity-regulated cytoskeleton-associated protein
ATF3 activating transcription factor 3
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2
BHLHE41 basic helix-loop-helix family, member e41
C19ORF26 chromosome 19 open reading frame 26
CD300C CD300c molecule
CDH8 cadherin 8, type 2
CEP112 centrosomal protein 112kDa
CLIP1 CAP-GLY domain containing linker protein 1
CNTN1 contactin 1
COL4A2 collagen, type IV, alpha 2
CPEB3 cytoplasmic polyadenylation element binding protein 3
CPNE7 copine VII
CST4 cystatin S
CTSE cathepsin E
CTSZ cathepsin Z
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1
CYLD cylindromatosis (turban tumor syndrome)
DDIT3 DNA-damage-inducible transcript 3
DLC1 DLC1 Rho GTPase activating protein
DOPEY2 dopey family member 2
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EGR4 early growth response 4
EHD2 EH-domain containing 2
FAM129A family with sequence similarity 129, member A
FAM46C family with sequence similarity 46, member C
FGD1 FYVE, RhoGEF and PH domain containing 1
FGFR1 fibroblast growth factor receptor 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FSCN3 fascin actin-bundling protein 3, testicular
GEM GTP binding protein overexpressed in skeletal muscle
GFER growth factor, augmenter of liver regeneration
GNL1 guanine nucleotide binding protein-like 1
GPR137 G protein-coupled receptor 137
GRAMD1C GRAM domain containing 1C
GSDMB gasdermin B
GSK3A glycogen synthase kinase 3 alpha
HAMP hepcidin antimicrobial peptide
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HEMK1 HemK methyltransferase family member 1
HIST1H3B histone cluster 1, H3b
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
ICAM1 intercellular adhesion molecule 1
IGLJ3 immunoglobulin lambda joining 3
INHBE inhibin, beta E
JUN jun proto-oncogene
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KIAA1024 KIAA1024
LAT2 linker for activation of T cells family, member 2
LDB3 LIM domain binding 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MEF2C myocyte enhancer factor 2C
MOB3B MOB kinase activator 3B
NEB nebulin
NKX2-2 NK2 homeobox 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NUPR1 nuclear protein, transcriptional regulator, 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDHGA3 protocadherin gamma subfamily A, 3
PKNOX1 PBX/knotted 1 homeobox 1
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRAMEF12 PRAME family member 12
PRLH prolactin releasing hormone
PSG4 pregnancy specific beta-1-glycoprotein 4
PXDC1 PX domain containing 1
RFPL1S RFPL1 antisense RNA 1
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SATB1 SATB homeobox 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SIM2 single-minded family bHLH transcription factor 2
SPRR1B small proline-rich protein 1B
SRSF7 serine/arginine-rich splicing factor 7
SSX3 synovial sarcoma, X breakpoint 3
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
TM4SF1 transmembrane 4 L six family member 1
TMEM242 transmembrane protein 242
TMPRSS4 transmembrane protease, serine 4
TPMT thiopurine S-methyltransferase
TRIB2 tribbles pseudokinase 2
TUBA4B tubulin, alpha 4b
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
USP46 ubiquitin specific peptidase 46
WNT5A wingless-type MMTV integration site family, member 5A
XAF1 XIAP associated factor 1
ZBTB17 zinc finger and BTB domain containing 17
ZNF3 zinc finger protein 3
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
AFAP1 actin filament associated protein 1
AKAP12 A kinase (PRKA) anchor protein 12
ANKEF1 ankyrin repeat and EF-hand domain containing 1
ANP32A-IT1 ANP32A intronic transcript 1
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
APLP1 amyloid beta (A4) precursor-like protein 1
ARHGAP11A Rho GTPase activating protein 11A
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BIRC7 baculoviral IAP repeat containing 7
C5AR2 complement component 5a receptor 2
C8ORF44 chromosome 8 open reading frame 44
CAMK1 calcium/calmodulin-dependent protein kinase I
CCDC121 coiled-coil domain containing 121
CD3D CD3d molecule, delta (CD3-TCR complex)
CDK6 cyclin-dependent kinase 6
CENPO centromere protein O
CTC1 CTS telomere maintenance complex component 1
CUZD1 CUB and zona pellucida-like domains 1
DEPDC5 DEP domain containing 5
DMTN dematin actin binding protein
ECE1 endothelin converting enzyme 1
EGFL7 EGF-like-domain, multiple 7
ERCC2 excision repair cross-complementation group 2
ERO1L ERO1-like (S. cerevisiae)
FAM120C family with sequence similarity 120C
FAM86C1 family with sequence similarity 86, member C1
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FGL1 fibrinogen-like 1
GAMT guanidinoacetate N-methyltransferase
GBP2 guanylate binding protein 2, interferon-inducible
GFI1 growth factor independent 1 transcription repressor
GLB1L galactosidase, beta 1-like
GLS2 glutaminase 2 (liver, mitochondrial)
GMPR guanosine monophosphate reductase
GPR27 G protein-coupled receptor 27
GPX2 glutathione peroxidase 2
HIST1H1D histone cluster 1, H1d
HIST1H2AI histone cluster 1, H2ai
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
INCENP inner centromere protein antigens 135/155kDa
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCNK5 potassium channel, two pore domain subfamily K, member 5
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KLK8 kallikrein-related peptidase 8
LIME1 Lck interacting transmembrane adaptor 1
LMTK2 lemur tyrosine kinase 2
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAPK10 mitogen-activated protein kinase 10
MBNL3 muscleblind-like splicing regulator 3
METTL8 methyltransferase like 8
MMP2 matrix metallopeptidase 2
MUC3A mucin 3A, cell surface associated
NPFFR1 neuropeptide FF receptor 1
NPPA natriuretic peptide A
ONECUT2 one cut homeobox 2
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PCDHGA8 protocadherin gamma subfamily A, 8
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLCD1 phospholipase C, delta 1
PMCH pro-melanin-concentrating hormone
POM121 POM121 transmembrane nucleoporin
POMT2 protein-O-mannosyltransferase 2
PPARG peroxisome proliferator-activated receptor gamma
PRAMEF11 PRAME family member 11
PRSS53 protease, serine, 53
PTPRS protein tyrosine phosphatase, receptor type, S
PVRL3 poliovirus receptor-related 3
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF2 ring finger protein 2
RPL10L ribosomal protein L10-like
SCGB2A2 secretoglobin, family 2A, member 2
SECTM1 secreted and transmembrane 1
SELL selectin L
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SPTBN2 spectrin, beta, non-erythrocytic 2
STX1A syntaxin 1A (brain)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TDRD1 tudor domain containing 1
TM6SF1 transmembrane 6 superfamily member 1
TSC22D4 TSC22 domain family, member 4
UBQLN4 ubiquilin 4
VIPR1 vasoactive intestinal peptide receptor 1
WDR4 WD repeat domain 4
WDR76 WD repeat domain 76
WNT16 wingless-type MMTV integration site family, member 16
XAB2 XPA binding protein 2
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF239 zinc finger protein 239
ZNF446 zinc finger protein 446
ZNF492 zinc finger protein 492
ZNF804A zinc finger protein 804A