chlorambucil-3788 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the chlorambucil-3788 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADGRB2 adhesion G protein-coupled receptor B2
ADORA3 adenosine A3 receptor
AGXT alanine-glyoxylate aminotransferase
AICDA activation-induced cytidine deaminase
ALPPL2 alkaline phosphatase, placental-like 2
ANK1 ankyrin 1, erythrocytic
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
ATF5 activating transcription factor 5
C14ORF105 chromosome 14 open reading frame 105
C8ORF44 chromosome 8 open reading frame 44
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CADM4 cell adhesion molecule 4
CD4 CD4 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CES3 carboxylesterase 3
CGA glycoprotein hormones, alpha polypeptide
CIB2 calcium and integrin binding family member 2
CORO7 coronin 7
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSN3 casein kappa
CT55 cancer/testis antigen 55
CTAG2 cancer/testis antigen 2
DCLK2 doublecortin-like kinase 2
DIAPH2-AS1 DIAPH2 antisense RNA 1
ELL elongation factor RNA polymerase II
EXTL1 exostosin-like glycosyltransferase 1
FAM76A family with sequence similarity 76, member A
FLOT1 flotillin 1
FXYD2 FXYD domain containing ion transport regulator 2
GAS1 growth arrest-specific 1
GGT1 gamma-glutamyltransferase 1
GJA8 gap junction protein, alpha 8, 50kDa
GOLGA2P5 golgin A2 pseudogene 5
GP1BB glycoprotein Ib (platelet), beta polypeptide
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
GYPC glycophorin C (Gerbich blood group)
HAND1 heart and neural crest derivatives expressed 1
HDAC11 histone deacetylase 11
HDAC6 histone deacetylase 6
HFE hemochromatosis
HOPX HOP homeobox
HRASLS2 HRAS-like suppressor 2
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
IL32 interleukin 32
IQCC IQ motif containing C
IVL involucrin
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KIF13A kinesin family member 13A
LAG3 lymphocyte-activation gene 3
LAT2 linker for activation of T cells family, member 2
LINC00652 long intergenic non-protein coding RNA 652
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MECOM MDS1 and EVI1 complex locus
MED25 mediator complex subunit 25
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MST1 macrophage stimulating 1
MUC8 mucin 8
MYO15A myosin XVA
NOP16 NOP16 nucleolar protein
OAZ3 ornithine decarboxylase antizyme 3
OR6A2 olfactory receptor, family 6, subfamily A, member 2
OR7A10 olfactory receptor, family 7, subfamily A, member 10
PART1 prostate androgen-regulated transcript 1 (non-protein coding)
PHC3 polyhomeotic homolog 3 (Drosophila)
PIGR polymeric immunoglobulin receptor
PNPLA3 patatin-like phospholipase domain containing 3
POU3F2 POU class 3 homeobox 2
PROX1 prospero homeobox 1
PRUNE2 prune homolog 2 (Drosophila)
RAB11FIP3 RAB11 family interacting protein 3 (class II)
RAP1GAP RAP1 GTPase activating protein
RASAL2 RAS protein activator like 2
REEP2 receptor accessory protein 2
RHAG Rh-associated glycoprotein
RIN3 Ras and Rab interactor 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SIDT2 SID1 transmembrane family, member 2
SYN3 synapsin III
TGFB1 transforming growth factor, beta 1
TLDC1 TBC/LysM-associated domain containing 1
TLX3 T-cell leukemia homeobox 3
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TP73-AS1 TP73 antisense RNA 1
TREM1 triggering receptor expressed on myeloid cells 1
TTC12 tetratricopeptide repeat domain 12
UBE2I ubiquitin-conjugating enzyme E2I
VAV1 vav 1 guanine nucleotide exchange factor
VTN vitronectin
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZNF518A zinc finger protein 518A

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AFF4 AF4/FMR2 family, member 4
ANP32A-IT1 ANP32A intronic transcript 1
APOL6 apolipoprotein L, 6
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARSB arylsulfatase B
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BAX BCL2-associated X protein
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC186 coiled-coil domain containing 186
CCNK cyclin K
CCNT1 cyclin T1
CCP110 centriolar coiled coil protein 110kDa
CD82 CD82 molecule
CDK6 cyclin-dependent kinase 6
CEP295 centrosomal protein 295kDa
CHM choroideremia (Rab escort protein 1)
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CLCN6 chloride channel, voltage-sensitive 6
CLEC2B C-type lectin domain family 2, member B
COPZ2 coatomer protein complex, subunit zeta 2
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DEPDC1 DEP domain containing 1
EDIL3 EGF-like repeats and discoidin I-like domains 3
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ELP6 elongator acetyltransferase complex subunit 6
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
ERCC4 excision repair cross-complementation group 4
EREG epiregulin
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EXOC5 exocyst complex component 5
FKBP10 FK506 binding protein 10, 65 kDa
FRS2 fibroblast growth factor receptor substrate 2
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GMEB1 glucocorticoid modulatory element binding protein 1
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GPR21 G protein-coupled receptor 21
GTF2I general transcription factor IIi
HIST1H1D histone cluster 1, H1d
HIST1H3C histone cluster 1, H3c
HIST1H4C histone cluster 1, H4c
IPO8 importin 8
KDM8 lysine (K)-specific demethylase 8
KIAA0754 KIAA0754
KIFC1 kinesin family member C1
KPNA5 karyopherin alpha 5 (importin alpha 6)
LIPG lipase, endothelial
LMAN1 lectin, mannose-binding, 1
LOC157562 uncharacterized LOC157562
METTL16 methyltransferase like 16
MFSD6 major facilitator superfamily domain containing 6
MIS18BP1 MIS18 binding protein 1
MOXD1 monooxygenase, DBH-like 1
MUM1 melanoma associated antigen (mutated) 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPM3 nucleophosmin/nucleoplasmin 3
ODF2 outer dense fiber of sperm tails 2
OSMR oncostatin M receptor
PADI1 peptidyl arginine deiminase, type I
PARPBP PARP1 binding protein
PDE12 phosphodiesterase 12
POLH polymerase (DNA directed), eta
PRF1 perforin 1 (pore forming protein)
PTGFR prostaglandin F receptor (FP)
RAB36 RAB36, member RAS oncogene family
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RFX7 regulatory factor X, 7
SAYSD1 SAYSVFN motif domain containing 1
SCAMP5 secretory carrier membrane protein 5
SCYL2 SCY1-like 2 (S. cerevisiae)
SELL selectin L
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SLAMF7 SLAM family member 7
SLC46A3 solute carrier family 46, member 3
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SPIN1 spindlin 1
SPTBN2 spectrin, beta, non-erythrocytic 2
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCTN2 tectonic family member 2
TET3 tet methylcytosine dioxygenase 3
TMEM121 transmembrane protein 121
TMEM209 transmembrane protein 209
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRAC T cell receptor alpha constant
VLDLR very low density lipoprotein receptor
ZBTB6 zinc finger and BTB domain containing 6
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF286A zinc finger protein 286A
ZNF334 zinc finger protein 334
ZNF492 zinc finger protein 492
ZNF639 zinc finger protein 639
ZNF695 zinc finger protein 695
ZNF76 zinc finger protein 76