childhood leukemia Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A leukemia that occurs in children. (Human Disease Ontology, DOID_7757)
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Genes

143 genes co-occuring with the disease childhood leukemia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
ASRGL1 asparaginase like 1 1.55734
ETV6 ets variant 6 1.43552
PBX1 pre-B-cell leukemia homeobox 1 1.35289
HLA-DOA major histocompatibility complex, class II, DO alpha 1.22692
RUNX1 runt-related transcription factor 1 1.14433
TCF3 transcription factor 3 1.07824
HMCES 5-hydroxymethylcytosine (hmC) binding, ES cell-specific 0.937044
CBX8 chromobox homolog 8 0.929173
CHL1 cell adhesion molecule L1-like 0.918848
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 0.893769
RSPO3 R-spondin 3 0.874919
SH3GL1 SH3-domain GRB2-like 1 0.870825
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 0.849126
WLS wntless Wnt ligand secretion mediator 0.792131
F8A2 coagulation factor VIII-associated 2 0.786394
F8A1 coagulation factor VIII-associated 1 0.786394
HOXA6 homeobox A6 0.785984
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.785165
RPLP2 ribosomal protein, large, P2 0.776977
BCLAF1 BCL2-associated transcription factor 1 0.77207
PCDH9 protocadherin 9 0.759416
EAF2 ELL associated factor 2 0.74436
CASP8AP2 caspase 8 associated protein 2 0.743547
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 0.71925
HLA-DMB major histocompatibility complex, class II, DM beta 0.705144
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 0.684692
FLT3 fms-related tyrosine kinase 3 0.684292
TYMS thymidylate synthetase 0.671925
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.658422
IKZF1 IKAROS family zinc finger 1 (Ikaros) 0.650508
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.632777
MAN1A1 mannosidase, alpha, class 1A, member 1 0.6214
TRPM5 transient receptor potential cation channel, subfamily M, member 5 0.615529
MUT methylmalonyl CoA mutase 0.587054
AKR1C3 aldo-keto reductase family 1, member C3 0.579272
HOXB3 homeobox B3 0.575383
MXD4 MAX dimerization protein 4 0.573828
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 0.567997
WT1 Wilms tumor 1 0.559839
ARID5B AT rich interactive domain 5B (MRF1-like) 0.554015
DHFR dihydrofolate reductase 0.549359
KAT6A K(lysine) acetyltransferase 6A 0.538118
TRIM27 tripartite motif containing 27 0.537731
CD19 CD19 molecule 0.537344
HOXA4 homeobox A4 0.527676
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 0.524974
AFF1 AF4/FMR2 family, member 1 0.518034
SIAH2 siah E3 ubiquitin protein ligase 2 0.515725
ADGRG1 adhesion G protein-coupled receptor G1 0.506507
TSPAN7 tetraspanin 7 0.503824
PREB prolactin regulatory element binding 0.503824
ECT2 epithelial cell transforming 2 0.503058
CLEC11A C-type lectin domain family 11, member A 0.498849
KMT2A lysine (K)-specific methyltransferase 2A 0.497703
MAP3K12 mitogen-activated protein kinase kinase kinase 12 0.496175
BCR breakpoint cluster region 0.490835
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.475634
TPD52 tumor protein D52 0.47374
TPMT thiopurine S-methyltransferase 0.472604
CASP14 caspase 14, apoptosis-related cysteine peptidase 0.470711
DLX3 distal-less homeobox 3 0.464283
HOXD9 homeobox D9 0.459373
HLA-A major histocompatibility complex, class I, A 0.454847
SHOC2 soc-2 suppressor of clear homolog (C. elegans) 0.454093
ACTG1 actin gamma 1 0.449571
HOXA9 homeobox A9 0.442795
TCN2 transcobalamin II 0.438846
HIST1H1T histone cluster 1, H1t 0.434899
HES4 hes family bHLH transcription factor 4 0.426265
HFE hemochromatosis 0.424765
CPEB1 cytoplasmic polyadenylation element binding protein 1 0.424014
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.422515
FPGS folylpolyglutamate synthase 0.408666
GSTO1 glutathione S-transferase omega 1 0.406425
TRIM24 tripartite motif containing 24 0.405305
SLC19A1 solute carrier family 19 (folate transporter), member 1 0.404184
BLVRB biliverdin reductase B 0.399707
PIWIL1 piwi-like RNA-mediated gene silencing 1 0.396353
CREBBP CREB binding protein 0.395794
HHIP hedgehog interacting protein 0.392629
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 0.390769
NQO1 NAD(P)H dehydrogenase, quinone 1 0.390025
TLX3 T-cell leukemia homeobox 3 0.388538
SUOX sulfite oxidase 0.378143
FADD Fas (TNFRSF6)-associated via death domain 0.376661
SH2D1A SH2 domain containing 1A 0.367964
SIAH1 siah E3 ubiquitin protein ligase 1 0.365932
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae) 0.364454
AOX1 aldehyde oxidase 1 0.363347
HOXA5 homeobox A5 0.363347
MYB v-myb avian myeloblastosis viral oncogene homolog 0.359657
SHMT1 serine hydroxymethyltransferase 1 (soluble) 0.358551
UNC13D unc-13 homolog D (C. elegans) 0.358183
MIRLET7C microRNA let-7c 0.348614
OSTC oligosaccharyltransferase complex subunit (non-catalytic) 0.338341
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 0.335778
GSTM1 glutathione S-transferase mu 1 0.32373
COL11A2P1 collagen, type XI, alpha 2 pseudogene 1 0.32373
ADAR adenosine deaminase, RNA-specific 0.323365
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase 0.323365
COL11A2 collagen, type XI, alpha 2 0.323365
ELL elongation factor RNA polymerase II 0.319726
HLA-C major histocompatibility complex, class I, C 0.318635
IGF1 insulin-like growth factor 1 (somatomedin C) 0.313189
CRLF2 cytokine receptor-like factor 2 0.311739
CD37 CD37 molecule 0.305226
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.304503
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.300173
BIRC5 baculoviral IAP repeat containing 5 0.299812
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.298011
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.291539
NCOR1 nuclear receptor corepressor 1 0.29118
HRAS Harvey rat sarcoma viral oncogene homolog 0.281868
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.27794
RARA retinoic acid receptor, alpha 0.268332
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 0.265849
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.26514
MNX1 motor neuron and pancreas homeobox 1 0.262306
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.25877
NT5E 5'-nucleotidase, ecto (CD73) 0.258417
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 0.253831
MVP major vault protein 0.245747
GSTTP1 glutathione S-transferase theta pseudogene 1 0.235964
GSTT1 glutathione S-transferase theta 1 0.235616
IGFBP3 insulin-like growth factor binding protein 3 0.232836
CD34 CD34 molecule 0.231102
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3 0.223509
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.221793
RPTOR regulatory associated protein of MTOR, complex 1 0.211934
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 0.196139
EP300 E1A binding protein p300 0.194548
NCOA2 nuclear receptor coactivator 2 0.191719
MEIS1 Meis homeobox 1 0.190168
XDH xanthine dehydrogenase 0.178126
TFRC transferrin receptor 0.176757
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 0.176757
LMO2 LIM domain only 2 (rhombotin-like 1) 0.174354
SPTB spectrin, beta, erythrocytic 0.172799
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.168148
RAD50 RAD50 homolog (S. cerevisiae) 0.165217
MYH11 myosin, heavy chain 11, smooth muscle 0.163729
KRAS Kirsten rat sarcoma viral oncogene homolog 0.162908
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 0.162109