chenodeoxycholic acid-6012 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the chenodeoxycholic acid-6012 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
AQP3 aquaporin 3 (Gill blood group)
BMP8A bone morphogenetic protein 8a
C19ORF73 chromosome 19 open reading frame 73
CA4 carbonic anhydrase IV
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMK4 calcium/calmodulin-dependent protein kinase IV
CD6 CD6 molecule
CDYL chromodomain protein, Y-like
CEP162 centrosomal protein 162kDa
CES3 carboxylesterase 3
CGA glycoprotein hormones, alpha polypeptide
CHM choroideremia (Rab escort protein 1)
CYTH1 cytohesin 1
DCBLD2 discoidin, CUB and LCCL domain containing 2
DOK4 docking protein 4
DRD2 dopamine receptor D2
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
FASTKD2 FAST kinase domains 2
FGFR3 fibroblast growth factor receptor 3
FN1 fibronectin 1
FOXG1 forkhead box G1
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GRAMD1C GRAM domain containing 1C
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HPCAL4 hippocalcin like 4
HS6ST1 heparan sulfate 6-O-sulfotransferase 1
HSPB11 heat shock protein family B (small), member 11
IBSP integrin-binding sialoprotein
IFNA14 interferon, alpha 14
IL4R interleukin 4 receptor
ING4 inhibitor of growth family, member 4
IRF2BP1 interferon regulatory factor 2 binding protein 1
IRF4 interferon regulatory factor 4
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KLHL25 kelch-like family member 25
LEPR leptin receptor
LIME1 Lck interacting transmembrane adaptor 1
MST1L macrophage stimulating 1-like
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTSS1L metastasis suppressor 1-like
MUC6 mucin 6, oligomeric mucus/gel-forming
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NF1 neurofibromin 1
OSBP2 oxysterol binding protein 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCGF2 polycomb group ring finger 2
PCSK6 proprotein convertase subtilisin/kexin type 6
PER3 period circadian clock 3
PLCH2 phospholipase C, eta 2
PLEKHH3 pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
POU2F2 POU class 2 homeobox 2
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
RAD54B RAD54 homolog B (S. cerevisiae)
RASA3 RAS p21 protein activator 3
RHOBTB2 Rho-related BTB domain containing 2
RIN3 Ras and Rab interactor 3
RUNX1 runt-related transcription factor 1
SECTM1 secreted and transmembrane 1
SFTPB surfactant protein B
SH3GL3 SH3-domain GRB2-like 3
SHH sonic hedgehog
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SMC1A structural maintenance of chromosomes 1A
SOX9 SRY (sex determining region Y)-box 9
SPTBN1 spectrin, beta, non-erythrocytic 1
SSPN sarcospan
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STMN3 stathmin-like 3
TACR1 tachykinin receptor 1
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TLDC1 TBC/LysM-associated domain containing 1
TMEM206 transmembrane protein 206
TMLHE trimethyllysine hydroxylase, epsilon
TMPRSS15 transmembrane protease, serine 15
TRIM3 tripartite motif containing 3
TSC22D2 TSC22 domain family, member 2
UPK3B uroplakin 3B
UROD uroporphyrinogen decarboxylase
USP2 ubiquitin specific peptidase 2
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VPS13B vacuolar protein sorting 13 homolog B (yeast)
WISP3 WNT1 inducible signaling pathway protein 3
WLS wntless Wnt ligand secretion mediator
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
YY2 YY2 transcription factor
ZBTB48 zinc finger and BTB domain containing 48
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF287 zinc finger protein 287

decreased expression

Symbol Name
ADAM23 ADAM metallopeptidase domain 23
ADGRG2 adhesion G protein-coupled receptor G2
AKAP12 A kinase (PRKA) anchor protein 12
AMH anti-Mullerian hormone
APLP1 amyloid beta (A4) precursor-like protein 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
B9D2 B9 protein domain 2
BAG4 BCL2-associated athanogene 4
C11ORF63 chromosome 11 open reading frame 63
C6ORF47 chromosome 6 open reading frame 47
CARTPT CART prepropeptide
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CDADC1 cytidine and dCMP deaminase domain containing 1
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CDON cell adhesion associated, oncogene regulated
CENPO centromere protein O
CEP97 centrosomal protein 97kDa
CFAP44 cilia and flagella associated protein 44
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHML choroideremia-like (Rab escort protein 2)
CRELD1 cysteine-rich with EGF-like domains 1
CRIP1 cysteine-rich protein 1 (intestinal)
CXXC4 CXXC finger protein 4
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DENND4A DENN/MADD domain containing 4A
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DRD1 dopamine receptor D1
DSCAM Down syndrome cell adhesion molecule
FAM204A family with sequence similarity 204, member A
FAM46C family with sequence similarity 46, member C
FRK fyn-related Src family tyrosine kinase
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GLS2 glutaminase 2 (liver, mitochondrial)
GMPR guanosine monophosphate reductase
GPC3 glypican 3
GPR3 G protein-coupled receptor 3
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HDAC11 histone deacetylase 11
HIST1H2BN histone cluster 1, H2bn
HIST1H4D histone cluster 1, H4d
IFI6 interferon, alpha-inducible protein 6
IL17RA interleukin 17 receptor A
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IRF6 interferon regulatory factor 6
LIN7B lin-7 homolog B (C. elegans)
LPAR3 lysophosphatidic acid receptor 3
LRRC37A2 leucine rich repeat containing 37, member A2
LRRTM2 leucine rich repeat transmembrane neuronal 2
MANEA mannosidase, endo-alpha
MAST3 microtubule associated serine/threonine kinase 3
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MFAP2 microfibrillar-associated protein 2
MRAS muscle RAS oncogene homolog
MRPL52 mitochondrial ribosomal protein L52
MTCP1 mature T-cell proliferation 1
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PCDHA6 protocadherin alpha 6
PLAC1 placenta-specific 1
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PMCH pro-melanin-concentrating hormone
POLL polymerase (DNA directed), lambda
PTCD1 pentatricopeptide repeat domain 1
RCAN3 RCAN family member 3
RIMBP2 RIMS binding protein 2
RPAP1 RNA polymerase II associated protein 1
RRP1 ribosomal RNA processing 1
SCN1B sodium channel, voltage gated, type I beta subunit
SERGEF secretion regulating guanine nucleotide exchange factor
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SPRY2 sprouty homolog 2 (Drosophila)
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TM6SF1 transmembrane 6 superfamily member 1
TMC7 transmembrane channel-like 7
TTBK2 tau tubulin kinase 2
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VLDLR very low density lipoprotein receptor
VNN2 vanin 2
ZBTB33 zinc finger and BTB domain containing 33
ZNF350 zinc finger protein 350
ZNF408 zinc finger protein 408
ZNF669 zinc finger protein 669
ZNF711 zinc finger protein 711
ZNF747 zinc finger protein 747
ZNHIT2 zinc finger, HIT-type containing 2
ZSCAN31 zinc finger and SCAN domain containing 31