checkpoint Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

389 genes co-occuring with the biological term checkpoint in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADRB1 adrenoceptor beta 1
AGER advanced glycosylation end product-specific receptor
AIM2 absent in melanoma 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANAPC1 anaphase promoting complex subunit 1
ANAPC10 anaphase promoting complex subunit 10
ANAPC15 anaphase promoting complex subunit 15
AP2M1 adaptor-related protein complex 2, mu 1 subunit
APC adenomatous polyposis coli
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APLF aprataxin and PNKP like factor
AR androgen receptor
ARR3 arrestin 3, retinal (X-arrestin)
ASF1A anti-silencing function 1A histone chaperone
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
ATRIP ATR interacting protein
AURKA aurora kinase A
AURKB aurora kinase B
AURKC aurora kinase C
AXIN2 axin 2
BBC3 BCL2 binding component 3
BCL2L1 BCL2-like 1
BID BH3 interacting domain death agonist
BIRC5 baculoviral IAP repeat containing 5
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRIP1 BRCA1 interacting protein C-terminal helicase 1
BRSK1 BR serine/threonine kinase 1
BTG2 BTG family, member 2
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
BUB3 BUB3 mitotic checkpoint protein
C19ORF40 chromosome 19 open reading frame 40
CASC5 cancer susceptibility candidate 5
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCL1 chemokine (C-C motif) ligand 1
CCNA2 cyclin A2
CCNB1 cyclin B1
CCND1 cyclin D1
CCNE1 cyclin E1
CCNG2 cyclin G2
CCNK cyclin K
CD226 CD226 molecule
CD274 CD274 molecule
CDC14A cell division cycle 14A
CDC14B cell division cycle 14B
CDC20 cell division cycle 20
CDC23 cell division cycle 23
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC25C cell division cycle 25C
CDC27 cell division cycle 27
CDC45 cell division cycle 45
CDC5L cell division cycle 5-like
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA5 cell division cycle associated 5
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDK9 cyclin-dependent kinase 9
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDT1 chromatin licensing and DNA replication factor 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPI centromere protein I
CFLAR CASP8 and FADD-like apoptosis regulator
CHD1L chromodomain helicase DNA binding protein 1-like
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CHEK2P2 checkpoint kinase 2 pseudogene 2
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
CHMP4C charged multivesicular body protein 4C
CINP cyclin-dependent kinase 2 interacting protein
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CLSPN claspin
COPS5 COP9 signalosome subunit 5
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CTBP1 C-terminal binding protein 1
CUEDC2 CUE domain containing 2
CUL4A cullin 4A
DBF4 DBF4 zinc finger
DBF4B DBF4 zinc finger B
DCLRE1A DNA cross-link repair 1A
DCLRE1B DNA cross-link repair 1B
DCLRE1C DNA cross-link repair 1C
DDB1 damage-specific DNA binding protein 1, 127kDa
DDIT4 DNA-damage-inducible transcript 4
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
DEC1 deleted in esophageal cancer 1
DIDO1 death inducer-obliterator 1
DMC1 DNA meiotic recombinase 1
DMD dystrophin
DNM1L dynamin 1-like
DNM2 dynamin 2
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUX4L1 double homeobox 4 like 1
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
E2F1 E2F transcription factor 1
E2F6 E2F transcription factor 6
EGFR epidermal growth factor receptor
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ERCC6L excision repair cross-complementation group 6-like
ERP44 endoplasmic reticulum protein 44
EXO1 exonuclease 1
FAM175A family with sequence similarity 175, member A
FANCC Fanconi anemia, complementation group C
FANCD2 Fanconi anemia, complementation group D2
FANCM Fanconi anemia, complementation group M
FBXO6 F-box protein 6
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FHIT fragile histidine triad
FOXM1 forkhead box M1
FOXN3 forkhead box N3
FOXO3 forkhead box O3
FYN FYN proto-oncogene, Src family tyrosine kinase
GADD45A growth arrest and DNA-damage-inducible, alpha
GDE1 glycerophosphodiester phosphodiesterase 1
GLI1 GLI family zinc finger 1
GMNN geminin, DNA replication inhibitor
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GPC1 glypican 1
GSG2 germ cell associated 2 (haspin)
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HAVCR1 hepatitis A virus cellular receptor 1
HAVCR2 hepatitis A virus cellular receptor 2
HELB helicase (DNA) B
HIPK2 homeodomain interacting protein kinase 2
HMGB1 high mobility group box 1
HOXB13 homeobox B13
HRAS Harvey rat sarcoma viral oncogene homolog
HSF1 heat shock transcription factor 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HTRA2 HtrA serine peptidase 2
HUS1 HUS1 checkpoint homolog (S. pombe)
IDO1 indoleamine 2,3-dioxygenase 1
IFI16 interferon, gamma-inducible protein 16
IFNB1 interferon, beta 1, fibroblast
IK IK cytokine, down-regulator of HLA II
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
ILK integrin-linked kinase
INCENP inner centromere protein antigens 135/155kDa
ISG15 ISG15 ubiquitin-like modifier
KAT5 K(lysine) acetyltransferase 5
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KDM5B lysine (K)-specific demethylase 5B
KIF11 kinesin family member 11
KLF4 Kruppel-like factor 4 (gut)
KLLN killin, p53-regulated DNA replication inhibitor
KLRAP1 killer cell lectin-like receptor subfamily A pseudogene 1
KMT2A lysine (K)-specific methyltransferase 2A
KNSTRN kinetochore-localized astrin/SPAG5 binding protein
LAT linker for activation of T cells
LATS1 large tumor suppressor kinase 1
LIG1 ligase I, DNA, ATP-dependent
LIMK2 LIM domain kinase 2
LMAN1 lectin, mannose-binding, 1
LMAN1L lectin, mannose-binding, 1 like
LYN LYN proto-oncogene, Src family tyrosine kinase
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAD2L1BP MAD2L1 binding protein
MAN1A1 mannosidase, alpha, class 1A, member 1
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MAPT microtubule-associated protein tau
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MCL1 myeloid cell leukemia 1
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM7 minichromosome maintenance complex component 7
MCPH1 microcephalin 1
MDC1 mediator of DNA-damage checkpoint 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MIR106B microRNA 106b
MIR15A microRNA 15a
MIR16-1 microRNA 16-1
MIR28 microRNA 28
MIR371A microRNA 371a
MIR574 microRNA 574
MIS12 MIS12 kinetochore complex component
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MSH2 mutS homolog 2
MTA1 metastasis associated 1
MTBP MDM2 binding protein
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUTYH mutY homolog
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NABP2 nucleic acid binding protein 2
NBN nibrin
NDC80 NDC80 kinetochore complex component
NDE1 nudE neurodevelopment protein 1
NEK1 NIMA-related kinase 1
NEK11 NIMA-related kinase 11
NEK2 NIMA-related kinase 2
NEK6 NIMA-related kinase 6
NEK9 NIMA-related kinase 9
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NLRP3 NLR family, pyrin domain containing 3
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae)
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
NUP153 nucleoporin 153kDa
PALB2 partner and localizer of BRCA2
PARK2 parkin RBR E3 ubiquitin protein ligase
PARL presenilin associated, rhomboid-like
PARP1 poly (ADP-ribose) polymerase 1
PBK PDZ binding kinase
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PCNA proliferating cell nuclear antigen
PDCD1 programmed cell death 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDS5A PDS5 cohesin associated factor A
PEBP1 phosphatidylethanolamine binding protein 1
PER3 period circadian clock 3
PGR progesterone receptor
PIAS1 protein inhibitor of activated STAT, 1
PIAS4 protein inhibitor of activated STAT, 4
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PINK1 PTEN induced putative kinase 1
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PML promyelocytic leukemia
POLDIP3 polymerase (DNA-directed), delta interacting protein 3
POLH polymerase (DNA directed), eta
POLK polymerase (DNA directed) kappa
PPAPDC2 phosphatidic acid phosphatase type 2 domain containing 2
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4
PPP5C protein phosphatase 5, catalytic subunit
PPP6C protein phosphatase 6, catalytic subunit
PRAP1 proline-rich acidic protein 1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRMT1 protein arginine methyltransferase 1
PRPF4 pre-mRNA processing factor 4
PRPF4B pre-mRNA processing factor 4B
PTEN phosphatase and tensin homolog
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTTG1 pituitary tumor-transforming 1
RAB6A RAB6A, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAD1 RAD1 checkpoint DNA exonuclease
RAD17 RAD17 homolog (S. pombe)
RAD18 RAD18 E3 ubiquitin protein ligase
RAD50 RAD50 homolog (S. cerevisiae)
RAD51C RAD51 paralog C
RAD9A RAD9 homolog A (S. pombe)
RAD9B RAD9 homolog B (S. pombe)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RALGDS ral guanine nucleotide dissociation stimulator
RAN RAN, member RAS oncogene family
RB1 retinoblastoma 1
RBBP8 retinoblastoma binding protein 8
RECQL RecQ helicase-like
RFWD3 ring finger and WD repeat domain 3
RHOA ras homolog family member A
RIF1 replication timing regulatory factor 1
RIPK2 receptor-interacting serine-threonine kinase 2
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RPA1 replication protein A1, 70kDa
RPA2 replication protein A2, 32kDa
RPA4 replication protein A4, 30kDa
RPGRIP1L RPGRIP1-like
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPT7 septin 7
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SETMAR SET domain and mariner transposase fusion gene
SF3B2 splicing factor 3b, subunit 2, 145kDa
SFN stratifin
SGOL1 shugoshin-like 1 (S. pombe)
SIAH1 siah E3 ubiquitin protein ligase 1
SIRT1 sirtuin 1
SKA1 spindle and kinetochore associated complex subunit 1
SKA2 spindle and kinetochore associated complex subunit 2
SKA3 spindle and kinetochore associated complex subunit 3
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLX4 SLX4 structure-specific endonuclease subunit
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMC1A structural maintenance of chromosomes 1A
SMC3 structural maintenance of chromosomes 3
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNCG synuclein, gamma (breast cancer-specific protein 1)
SOD2 superoxide dismutase 2, mitochondrial
SOX7 SRY (sex determining region Y)-box 7
SPAG5 sperm associated antigen 5
SPDL1 spindle apparatus coiled-coil protein 1
SPDYA speedy/RINGO cell cycle regulator family member A
SPDYC speedy/RINGO cell cycle regulator family member C
SPINK7 serine peptidase inhibitor, Kazal type 7 (putative)
STARD9 StAR-related lipid transfer (START) domain containing 9
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK11 serine/threonine kinase 11
STMN1 stathmin 1
STRAP serine/threonine kinase receptor associated protein
SYF2 SYF2 pre-mRNA-splicing factor
TAC1 tachykinin, precursor 1
TACR1 tachykinin receptor 1
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
TAOK1 TAO kinase 1
TERC telomerase RNA component
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TGFB1 transforming growth factor, beta 1
TICRR TOPBP1-interacting checkpoint and replication regulator
TIGIT T cell immunoreceptor with Ig and ITIM domains
TIMELESS timeless circadian clock
TIPIN TIMELESS interacting protein
TLK1 tousled-like kinase 1
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TOP2A topoisomerase (DNA) II alpha 170kDa
TOP3A topoisomerase (DNA) III alpha
TOPBP1 topoisomerase (DNA) II binding protein 1
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TP53I3 tumor protein p53 inducible protein 3
TP63 tumor protein p63
TP73 tumor protein p73
TPR translocated promoter region, nuclear basket protein
TREX1 three prime repair exonuclease 1
TRIB3 tribbles pseudokinase 3
TRIP13 thyroid hormone receptor interactor 13
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
TSG101 tumor susceptibility 101
TTI2 TELO2 interacting protein 2
TTK TTK protein kinase
TUFM Tu translation elongation factor, mitochondrial
TWIST1 twist family bHLH transcription factor 1
UBD ubiquitin D
UBE2C ubiquitin-conjugating enzyme E2C
UBE2Q2 ubiquitin-conjugating enzyme E2Q family member 2
UFD1L ubiquitin fusion degradation 1 like (yeast)
UHRF1 ubiquitin-like with PHD and ring finger domains 1
UIMC1 ubiquitin interaction motif containing 1
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast)
USP17L9P ubiquitin specific peptidase 17-like family member 9, pseudogene
USP39 ubiquitin specific peptidase 39
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VCP valosin containing protein
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae)
VTCN1 V-set domain containing T cell activation inhibitor 1
WEE1 WEE1 G2 checkpoint kinase
WRN Werner syndrome, RecQ helicase-like
WWOX WW domain containing oxidoreductase
XAF1 XIAP associated factor 1
XPA xeroderma pigmentosum, complementation group A
XPO1 exportin 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
ZBTB17 zinc finger and BTB domain containing 17
ZFYVE19 zinc finger, FYVE domain containing 19
ZW10 zw10 kinetochore protein
ZWINT ZW10 interacting kinetochore protein