checkpoint clamp complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage. (Gene Ontology, GO_0030896)
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Genes

92 proteins co-occuring with the checkpoint clamp complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
RAD17 RAD17 homolog (S. pombe) 1.81983
RAD9A RAD9 homolog A (S. pombe) 1.77144
HUS1 HUS1 checkpoint homolog (S. pombe) 1.70137
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 1.50509
TOPBP1 topoisomerase (DNA) II binding protein 1 1.49888
FETUB fetuin B 1.2055
DOCK11 dedicator of cytokinesis 11 1.16594
RFC2 replication factor C (activator 1) 2, 40kDa 1.1603
RFC3 replication factor C (activator 1) 3, 38kDa 1.15672
RFC4 replication factor C (activator 1) 4, 37kDa 1.15211
ZNF83 zinc finger protein 83 1.13881
RFC5 replication factor C (activator 1) 5, 36.5kDa 1.07613
ATRIP ATR interacting protein 1.03679
FBN2 fibrillin 2 0.980987
PCNA proliferating cell nuclear antigen 0.971297
RFC1 replication factor C (activator 1) 1, 145kDa 0.964069
SBK1 SH3 domain binding kinase 1 0.905531
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.889321
ATR ATR serine/threonine kinase 0.878251
ATP5I ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E 0.851583
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 0.850206
AGA aspartylglucosaminidase 0.811652
MFSD2A major facilitator superfamily domain containing 2A 0.807065
MPG N-methylpurine-DNA glycosylase 0.782784
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.762707
S100A12 S100 calcium binding protein A12 0.747737
MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) 0.722134
RAD18 RAD18 E3 ubiquitin protein ligase 0.709693
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 0.673328
CCNC cyclin C 0.659482
MUTYH mutY homolog 0.638861
HSPA1L heat shock 70kDa protein 1-like 0.630318
POLE polymerase (DNA directed), epsilon, catalytic subunit 0.629892
TRIT1 tRNA isopentenyltransferase 1 0.625632
CHEK1 checkpoint kinase 1 0.624781
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 0.612048
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 0.577999
GLYAT glycine-N-acyltransferase 0.555145
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21 0.54194
MFRP membrane frizzled-related protein 0.526341
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 0.516124
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.504724
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase 0.502693
F2 coagulation factor II (thrombin) 0.493775
UGCG UDP-glucose ceramide glucosyltransferase 0.486904
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 0.463598
EXO1 exonuclease 1 0.444085
ATAD5 ATPase family, AAA domain containing 5 0.409479
ATM ATM serine/threonine kinase 0.407919
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.393549
FPGS folylpolyglutamate synthase 0.385436
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 0.382739
GCG glucagon 0.380814
PCCA propionyl CoA carboxylase, alpha polypeptide 0.373516
QARS glutaminyl-tRNA synthetase 0.371599
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 0.351002
INSIG2 insulin induced gene 2 0.346071
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog 0.324576
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 0.319328
PITX1 paired-like homeodomain 1 0.314465
KLK15 kallikrein-related peptidase 15 0.29994
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 0.297342
GAA glucosidase, alpha; acid 0.292897
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.287352
MANF mesencephalic astrocyte-derived neurotrophic factor 0.283663
POLH polymerase (DNA directed), eta 0.267139
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 0.259473
C4A complement component 4A (Rodgers blood group) 0.251476
REV1 REV1, polymerase (DNA directed) 0.240636
APOA4 apolipoprotein A-IV 0.239197
INSIG1 insulin induced gene 1 0.237401
CLCA4 chloride channel accessory 4 0.237401
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 0.235249
DNA2 DNA replication helicase/nuclease 2 0.233817
NPEPPS aminopeptidase puromycin sensitive 0.231672
IFNGR1 interferon gamma receptor 1 0.231315
CRYGS crystallin, gamma S 0.224913
HSPA1B heat shock 70kDa protein 1B 0.224204
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 0.222436
CLCA2 chloride channel accessory 2 0.219617
APOA5 apolipoprotein A-V 0.215761
CLCA1 chloride channel accessory 1 0.204039
PRIM1 primase, DNA, polypeptide 1 (49kDa) 0.203699
CRYGD crystallin, gamma D 0.197662
ERCC2 excision repair cross-complementation group 2 0.193719
CBS cystathionine-beta-synthase 0.180045
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1 0.176587
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.168349
SOD3 superoxide dismutase 3, extracellular 0.165697
GGT1 gamma-glutamyltransferase 1 0.162763
CA13 carbonic anhydrase XIII 0.158315
CDC7 cell division cycle 7 0.156688