cerebral palsy Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A brain disease that is caused by damage to the motor control centers of the developing brain during pregnancy, during childbirth or after birth, which affects muscle movement and balance. (Human Disease Ontology, DOID_1969)
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Genes

338 genes co-occuring with the disease cerebral palsy in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 1.84954
CPVL carboxypeptidase, vitellogenic-like 1.79165
AMIGO2 adhesion molecule with Ig-like domain 2 1.78939
AVPR2 arginine vasopressin receptor 2 1.62336
AP4M1 adaptor-related protein complex 4, mu 1 subunit 1.58894
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 1.52996
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit 1.52468
AP4S1 adaptor-related protein complex 4, sigma 1 subunit 1.42542
AP4B1 adaptor-related protein complex 4, beta 1 subunit 1.37338
GCDH glutaryl-CoA dehydrogenase 1.33545
GCH1 GTP cyclohydrolase 1 1.21652
PLP1 proteolipid protein 1 1.11645
KANK1 KN motif and ankyrin repeat domains 1 1.07866
MBP myelin basic protein 1.07782
FSCB fibrous sheath CABYR binding protein 1.04041
TRAK1 trafficking protein, kinesin binding 1 1.03662
F5 coagulation factor V (proaccelerin, labile factor) 1.02988
ZC4H2 zinc finger, C4H2 domain containing 0.995705
OR7E87P olfactory receptor, family 7, subfamily E, member 87 pseudogene 0.983479
HPRT1 hypoxanthine phosphoribosyltransferase 1 0.98011
SEMA5B sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B 0.96918
MND1 meiotic nuclear divisions 1 homolog (S. cerevisiae) 0.952856
COL4A1 collagen, type IV, alpha 1 0.94078
RAB9B RAB9B, member RAS oncogene family 0.909376
MC2R melanocortin 2 receptor (adrenocorticotropic hormone) 0.89623
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) 0.868368
IL6 interleukin 6 0.859362
BDNF brain-derived neurotrophic factor 0.857315
ERAS ES cell expressed Ras 0.851173
FBXO45 F-box protein 45 0.842573
ATL1 atlastin GTPase 1 0.835198
PURA purine-rich element binding protein A 0.822488
FOXD4 forkhead box D4 0.814693
SP6 Sp6 transcription factor 0.801974
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.796642
PSG6 pregnancy specific beta-1-glycoprotein 6 0.786394
ADCK2 aarF domain containing kinase 2 0.782298
OR13G1 olfactory receptor, family 13, subfamily G, member 1 0.772479
SIRPA signal-regulatory protein alpha 0.766351
SAP30BP SAP30 binding protein 0.763494
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 0.763086
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.755749
HADH hydroxyacyl-CoA dehydrogenase 0.754934
FOXH1 forkhead box H1 0.749644
TNF tumor necrosis factor 0.745578
COPS3 COP9 signalosome subunit 3 0.736243
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.731381
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 0.721673
BMP2K BMP2 inducible kinase 0.712392
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) 0.707157
CAPN15 calpain 15 0.691896
GLUD1 glutamate dehydrogenase 1 0.690694
IL1B interleukin 1, beta 0.685891
OR10K2 olfactory receptor, family 10, subfamily K, member 2 0.676706
CDH12 cadherin 12, type 2 (N-cadherin 2) 0.657234
PQBP1 polyglutamine binding protein 1 0.65288
MYPN myopalladin 0.628457
HFM1 HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae) 0.622575
VCP valosin containing protein 0.621008
EPGN epithelial mitogen 0.606543
MARK3 MAP/microtubule affinity-regulating kinase 3 0.60303
TTN titin 0.60225
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.60186
FRRS1L ferric-chelate reductase 1-like 0.595623
VIM vimentin 0.590948
CALB1 calbindin 1, 28kDa 0.583552
MCOLN1 mucolipin 1 0.57305
LDB3 LIM domain binding 3 0.568386
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 0.567997
IGF1 insulin-like growth factor 1 (somatomedin C) 0.562946
VAT1 vesicle amine transport 1 0.562558
ELOVL4 ELOVL fatty acid elongase 4 0.560227
APOE apolipoprotein E 0.55712
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.556344
NOTCH1 notch 1 0.555956
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.554403
DOCK8 dedicator of cytokinesis 8 0.553239
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.550134
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.545093
OR5K2 olfactory receptor, family 5, subfamily K, member 2 0.543542
S100B S100 calcium binding protein B 0.542767
TMOD4 tropomodulin 4 (muscle) 0.531154
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa 0.528063
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 0.527676
SIX2 SIX homeobox 2 0.526904
DEDD death effector domain containing 0.526518
GABARAPL1 GABA(A) receptor-associated protein like 1 0.519575
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 0.51919
PDHX pyruvate dehydrogenase complex, component X 0.517649
TGM6 transglutaminase 6 0.510728
ARG1 arginase 1 0.508808
RAB40AL RAB40A, member RAS oncogene family-like 0.50689
NPTX1 neuronal pentraxin I 0.506123
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 0.496939
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 0.489311
DCX doublecortin 0.485885
GFAP glial fibrillary acidic protein 0.482084
ETV3 ets variant 3 0.476772
TCERG1 transcription elongation regulator 1 0.473361
PRAMEF20 PRAME family member 20 0.472604
ALB albumin 0.472604
LY96 lymphocyte antigen 96 0.460129
IL9 interleukin 9 0.452962
REXO1L1P REX1, RNA exonuclease 1 homolog (S. cerevisiae)-like 1, pseudogene 0.447687
OR3A1 olfactory receptor, family 3, subfamily A, member 1 0.446182
FUCA2 fucosidase, alpha-L- 2, plasma 0.444676
ADRB2 adrenoceptor beta 2, surface 0.443171
PER2 period circadian clock 2 0.440162
BEST3 bestrophin 3 0.438658
GCSH glycine cleavage system protein H (aminomethyl carrier) 0.434148
OR10R2 olfactory receptor, family 10, subfamily R, member 2 0.433021
POMC proopiomelanocortin 0.432646
BDH1 3-hydroxybutyrate dehydrogenase, type 1 0.431144
ALPP alkaline phosphatase, placental 0.430393
MOCS2 molybdenum cofactor synthesis 2 0.42664
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 0.42664
NTF3 neurotrophin 3 0.421765
OR4F29 olfactory receptor, family 4, subfamily F, member 29 0.420266
SUB1 SUB1 homolog (S. cerevisiae) 0.412405
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.410535
SLC19A3 solute carrier family 19 (thiamine transporter), member 3 0.406425
NMT1 N-myristoyltransferase 1 0.404184
TREM1 triggering receptor expressed on myeloid cells 1 0.403438
DNTT DNA nucleotidylexotransferase 0.401945
FICD FIC domain containing 0.401945
FZD3 frizzled class receptor 3 0.401572
F2 coagulation factor II (thrombin) 0.397471
NRN1 neuritin 1 0.394491
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 0.391885
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.390025
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) 0.390025
ALPPL2 alkaline phosphatase, placental-like 2 0.390025
ALPL alkaline phosphatase, liver/bone/kidney 0.388909
BEST2 bestrophin 2 0.387794
GAS7 growth arrest-specific 7 0.385193
DAAM1 dishevelled associated activator of morphogenesis 1 0.379997
ADD1 adducin 1 (alpha) 0.371847
TSPO translocator protein (18kDa) 0.371847
AGK acylglycerol kinase 0.371107
CHD1 chromodomain helicase DNA binding protein 1 0.369628
BGLAP bone gamma-carboxyglutamate (gla) protein 0.36741
AUTS2 autism susceptibility candidate 2 0.366671
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 0.365932
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 0.364824
EFS embryonal Fyn-associated substrate 0.364085
NTF4 neurotrophin 4 0.359289
CTPS1 CTP synthase 1 0.355235
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 0.354868
IL13RA1 interleukin 13 receptor, alpha 1 0.353763
TBR1 T-box, brain, 1 0.351555
LRRC38 leucine rich repeat containing 38 0.351187
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 0.346409
NPTX2 neuronal pentraxin II 0.342006
NARS asparaginyl-tRNA synthetase 0.337975
WRNIP1 Werner helicase interacting protein 1 0.335778
FA2H fatty acid 2-hydroxylase 0.334681
FUCA1 fucosidase, alpha-L- 1, tissue 0.331756
ADGRG1 adhesion G protein-coupled receptor G1 0.3292
ATG7 autophagy related 7 0.324458
NES nestin 0.32373
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.318272
C1QTNF5 C1q and tumor necrosis factor related protein 5 0.318272
PRSS21 protease, serine, 21 (testisin) 0.316092
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 0.314278
PFAS phosphoribosylformylglycinamidine synthase 0.313552
PLEKHN1 pleckstrin homology domain containing, family N member 1 0.312827
PNKD paroxysmal nonkinesigenic dyskinesia 0.311377
LACTB lactamase, beta 0.311377
MGST1 microsomal glutathione S-transferase 1 0.310652
CCDC27 coiled-coil domain containing 27 0.309928
PVALB parvalbumin 0.309566
IGFBP3 insulin-like growth factor binding protein 3 0.306672
CSN1S1 casein alpha s1 0.305587
MLF1 myeloid leukemia factor 1 0.304503
TCEA1 transcription elongation factor A (SII), 1 0.304142
PTN pleiotrophin 0.302698
ERCC6 excision repair cross-complementation group 6 0.301615
GLDC glycine dehydrogenase (decarboxylating) 0.300173
ADD3 adducin 3 (gamma) 0.299452
PAX6 paired box 6 0.298011
ARSA arylsulfatase A 0.294413
BMP4 bone morphogenetic protein 4 0.293694
FLNA filamin A, alpha 0.292975
TLR4 toll-like receptor 4 0.291539
NCS1 neuronal calcium sensor 1 0.290821
DUSP3 dual specificity phosphatase 3 0.287235
CKM creatine kinase, muscle 0.286519
KRT84 keratin 84, type II 0.285802
ADNP activity-dependent neuroprotector homeobox 0.285444
DMRT1 doublesex and mab-3 related transcription factor 1 0.280082
CAMP cathelicidin antimicrobial peptide 0.280082
TDG thymine-DNA glycosylase 0.279011
LTA lymphotoxin alpha 0.27794
PPT2 palmitoyl-protein thioesterase 2 0.277584
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.275089
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.274021
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.273664
CTNND2 catenin (cadherin-associated protein), delta 2 0.273308
CYB5A cytochrome b5 type A (microsomal) 0.271886
FBXW2 F-box and WD repeat domain containing 2 0.267977
LAX1 lymphocyte transmembrane adaptor 1 0.266913
CA10 carbonic anhydrase X 0.266203
ACOX1 acyl-CoA oxidase 1, palmitoyl 0.265494
HRC histidine rich calcium binding protein 0.26514
OPHN1 oligophrenin 1 0.264785
SDF4 stromal cell derived factor 4 0.264431
SOD2 superoxide dismutase 2, mitochondrial 0.261952
PPAN peter pan homolog (Drosophila) 0.260891
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 0.260891
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 0.260538
STIL SCL/TAL1 interrupting locus 0.260538
CD79A CD79a molecule, immunoglobulin-associated alpha 0.257005
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 0.255946
UBE3A ubiquitin protein ligase E3A 0.255241
SUMF1 sulfatase modifying factor 1 0.253479
COL4A2 collagen, type IV, alpha 2 0.251718
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 0.251015
CUX1 cut-like homeobox 1 0.249257
FKTN fukutin 0.248554
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 0.248203
SNRPA small nuclear ribonucleoprotein polypeptide A 0.246448
DYNLRB1 dynein, light chain, roadblock-type 1 0.245396
GNPAT glyceronephosphate O-acyltransferase 0.245046
ACAP3 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 0.241895
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.241546
ZBTB48 zinc finger and BTB domain containing 48 0.241196
GPANK1 G patch domain and ankyrin repeats 1 0.239799
PER1 period circadian clock 1 0.239101
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 0.237357
PANK1 pantothenate kinase 1 0.237009
ATG5 autophagy related 5 0.237009
ICT1 immature colon carcinoma transcript 1 0.235268
CSPG4 chondroitin sulfate proteoglycan 4 0.233878
PRRC2A proline-rich coiled-coil 2A 0.23353
TAC1 tachykinin, precursor 1 0.231102
RAET1E retinoic acid early transcript 1E 0.230409
L1CAM L1 cell adhesion molecule 0.221793
NGDN neuroguidin, EIF4E binding protein 0.22145
NGF nerve growth factor (beta polypeptide) 0.221108
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) 0.213959
RGMB repulsive guidance molecule family member b 0.213621
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.212608
WDFY2 WD repeat and FYVE domain containing 2 0.211597
EGR3 early growth response 3 0.210925
HNF4A hepatocyte nuclear factor 4, alpha 0.209248
IGLV3-10 immunoglobulin lambda variable 3-10 0.207912
NOG noggin 0.206913
COL6A1 collagen, type VI, alpha 1 0.205916
SDCBP syndecan binding protein (syntenin) 0.201962
PEG10 paternally expressed 10 0.200982
MSTN myostatin 0.198064
LPIN1 lipin 1 0.192344
IL10 interleukin 10 0.190168
PNP purine nucleoside phosphorylase 0.188938
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 0.188326
SHANK3 SH3 and multiple ankyrin repeat domains 3 0.188022
TPRG1L tumor protein p63 regulated 1-like 0.187113
PCNT pericentrin 0.18621
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.184424
CNTLN centlein, centrosomal protein 0.184128
FANCB Fanconi anemia, complementation group B 0.182957
VSX2 visual system homeobox 2 0.182375
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 0.18151
THEM4 thioesterase superfamily member 4 0.178682
NKX6-2 NK6 homeobox 2 0.178403
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 0.178126
OMG oligodendrocyte myelin glycoprotein 0.177301
IGLL5 immunoglobulin lambda-like polypeptide 5 0.175679
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) 0.174093
VIP vasoactive intestinal peptide 0.172799
NEUROD1 neuronal differentiation 1 0.170054
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.167915
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 0.167452
F3 coagulation factor III (thromboplastin, tissue factor) 0.167224
CSF1R colony stimulating factor 1 receptor 0.166995
OPRL1 opiate receptor-like 1 0.165217
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 0.165001
CYS1 cystin 1 0.164359
GSR glutathione reductase 0.163729
ELL elongation factor RNA polymerase II 0.163317
CHGB chromogranin B 0.161716
MCPH1 microcephalin 1 0.160021
BCO1 beta-carotene oxygenase 1 0.159658
PLIN1 perilipin 1 0.148391
BBS2 Bardet-Biedl syndrome 2 0.144679
GPBAR1 G protein-coupled bile acid receptor 1 0.143781
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.143318
ADGRV1 adhesion G protein-coupled receptor V1 0.143315
TAZ tafazzin 0.143138
PNPLA6 patatin-like phospholipase domain containing 6 0.142839
MIXL1 Mix paired-like homeobox 0.142666
FOLR1 folate receptor 1 (adult) 0.142413
PROCR protein C receptor, endothelial 0.142394
MLXIPL MLX interacting protein-like 0.142248
ASPA aspartoacylase 0.142241
POU2F3 POU class 2 homeobox 3 0.1419
AFF2 AF4/FMR2 family, member 2 0.14172
CHKA choline kinase alpha 0.141689
TOP3A topoisomerase (DNA) III alpha 0.141631
TBP TATA box binding protein 0.141351
FOXL2 forkhead box L2 0.140771
MCM8 minichromosome maintenance complex component 8 0.140016
GLB1 galactosidase, beta 1 0.139684
MUC6 mucin 6, oligomeric mucus/gel-forming 0.139346
TPH1 tryptophan hydroxylase 1 0.139332
GALC galactosylceramidase 0.139232
PIDD1 p53-induced death domain protein 1 0.138859
MNX1 motor neuron and pancreas homeobox 1 0.138539
HSPG2 heparan sulfate proteoglycan 2 0.138517
NKX2-1 NK2 homeobox 1 0.138375
TSPAN7 tetraspanin 7 0.138275
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.138252
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 0.138167
PAX8 paired box 8 0.138167
CS citrate synthase 0.137833
MAG myelin associated glycoprotein 0.13727
TSKU tsukushi, small leucine rich proteoglycan 0.127404
CD59 CD59 molecule, complement regulatory protein 0.124341
BSG basigin (Ok blood group) 0.122352
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 0.122004
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.119559
SPTBN1 spectrin, beta, non-erythrocytic 1 0.118805
LMNA lamin A/C 0.118296
MECP2 methyl CpG binding protein 2 0.117779
PDE5A phosphodiesterase 5A, cGMP-specific 0.117279
SPTBN2 spectrin, beta, non-erythrocytic 2 0.116477
STXBP1 syntaxin binding protein 1 0.115783
AAAS achalasia, adrenocortical insufficiency, alacrimia 0.11555
SUOX sulfite oxidase 0.113949
UROD uroporphyrinogen decarboxylase 0.112517
LCK LCK proto-oncogene, Src family tyrosine kinase 0.109776
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.109036
GUSB glucuronidase, beta 0.108656
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.108572
SCN2A sodium channel, voltage gated, type II alpha subunit 0.106893
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.106136
NPS neuropeptide S 0.103501
MLX MLX, MAX dimerization protein 0.101851