cerebral malaria Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A malaria that involves neurologic damage resulting from blockage of the blood vessels, caused due to the infection of the red blood cells by Plasmodium species. (Human Disease Ontology, DOID_14069)
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Genes

154 genes co-occuring with the disease cerebral malaria in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
CD36 CD36 molecule (thrombospondin receptor) 1.81419
SCARB2 scavenger receptor class B, member 2 1.81058
ICAM1 intercellular adhesion molecule 1 1.76275
SCARB1 scavenger receptor class B, member 1 1.74278
TNF tumor necrosis factor 1.50052
CXCL10 chemokine (C-X-C motif) ligand 10 1.16906
NSL1 NSL1, MIS12 kinetochore complex component 1.13289
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 1.11772
SELE selectin E 1.06648
VCAM1 vascular cell adhesion molecule 1 1.0442
LTA lymphotoxin alpha 1.03577
CXCR3 chemokine (C-X-C motif) receptor 3 0.975482
CD4 CD4 molecule 0.958287
PROCR protein C receptor, endothelial 0.945354
IL10 interleukin 10 0.897051
HMOX1 heme oxygenase 1 0.883521
KRT83 keratin 83, type II 0.838476
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 0.815104
ANGPT2 angiopoietin 2 0.803616
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 0.799103
IDO1 indoleamine 2,3-dioxygenase 1 0.788033
CXCL9 chemokine (C-X-C motif) ligand 9 0.783116
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) 0.779023
PRF1 perforin 1 (pore forming protein) 0.770027
ZBED9 zinc finger, BED-type containing 9 0.767576
IL1B interleukin 1, beta 0.758193
CLEC9A C-type lectin domain family 9, member A 0.750864
ANGPT1 angiopoietin 1 0.735838
HCAR1 hydroxycarboxylic acid receptor 1 0.733001
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.718443
LIN7A lin-7 homolog A (C. elegans) 0.70233
BTBD7 BTB (POZ) domain containing 7 0.695103
CTSW cathepsin W 0.67312
PBK PDZ binding kinase 0.660008
OR2B2 olfactory receptor, family 2, subfamily B, member 2 0.654067
PLAUR plasminogen activator, urokinase receptor 0.648138
CMC2 C-x(9)-C motif containing 2 0.643797
IFNAR1 interferon (alpha, beta and omega) receptor 1 0.623751
IL17RE interleukin 17 receptor E 0.605762
MYD88 myeloid differentiation primary response 88 0.60303
IFNG interferon, gamma 0.59952
IL17RD interleukin 17 receptor D 0.59874
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.598351
CD69 CD69 molecule 0.576939
TLR9 toll-like receptor 9 0.567609
BTLA B and T lymphocyte associated 0.566831
ESAM endothelial cell adhesion molecule 0.543542
IFNGR1 interferon gamma receptor 1 0.52729
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.526904
IL1A interleukin 1, alpha 0.526518
C5AR1 complement component 5a receptor 1 0.52536
ARF5 ADP-ribosylation factor 5 0.519961
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.517265
MID1 midline 1 0.514956
CCL3 chemokine (C-C motif) ligand 3 0.510344
NONO non-POU domain containing, octamer-binding 0.509959
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.505356
TCN2 transcobalamin II 0.500761
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.498849
IL6 interleukin 6 0.496939
ACMSD aminocarboxymuconate semialdehyde decarboxylase 0.496175
CLEC4A C-type lectin domain family 4, member A 0.495029
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.485505
IL4 interleukin 4 0.484744
C3AR1 complement component 3a receptor 1 0.477151
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 0.457864
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.449194
HRH4 histamine receptor H4 0.449194
ADGRE1 adhesion G protein-coupled receptor E1 0.446558
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.431519
SRPX2 sushi-repeat containing protein, X-linked 2 0.428516
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.42589
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.421765
EPO erythropoietin 0.413527
FOXP3 forkhead box P3 0.412405
VWF von Willebrand factor 0.404931
CD1E CD1e molecule 0.397098
FASLG Fas ligand (TNF superfamily, member 6) 0.390397
TLR2 toll-like receptor 2 0.379256
RTN3 reticulon 3 0.37555
HP haptoglobin 0.371847
HRH1 histamine receptor H1 0.371477
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.371477
HLA-B major histocompatibility complex, class I, B 0.371477
NELFCD negative elongation factor complex member C/D 0.369997
HLA-E major histocompatibility complex, class I, E 0.369258
HPR haptoglobin-related protein 0.365932
TGFB1 transforming growth factor, beta 1 0.362609
TRIM5 tripartite motif containing 5 0.348614
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) 0.347144
C5AR2 complement component 5a receptor 2 0.344941
CAPN2 calpain 2, (m/II) large subunit 0.344941
TLR8 toll-like receptor 8 0.340906
HRH2 histamine receptor H2 0.337608
SOCS2 suppressor of cytokine signaling 2 0.334681
CCL2 chemokine (C-C motif) ligand 2 0.332852
IRF1 interferon regulatory factor 1 0.332852
MAEA macrophage erythroblast attacher 0.3292
ALB albumin 0.326646
PEX2 peroxisomal biogenesis factor 2 0.326281
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.324823
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 0.317545
G6PD glucose-6-phosphate dehydrogenase 0.306672
SRCIN1 SRC kinase signaling inhibitor 1 0.304503
HDC histidine decarboxylase 0.302698
CCL4 chemokine (C-C motif) ligand 4 0.300894
MMP9 matrix metallopeptidase 9 0.297651
LGALS2 lectin, galactoside-binding, soluble, 2 0.289386
IL1RN interleukin 1 receptor antagonist 0.289027
TIMD4 T-cell immunoglobulin and mucin domain containing 4 0.285444
CARD17 caspase recruitment domain family, member 17 0.280439
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.267977
ARG1 arginase 1 0.265494
PF4 platelet factor 4 0.260184
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.257711
EPB41 erythrocyte membrane protein band 4.1 0.256299
SYVN1 synovial apoptosis inhibitor 1, synoviolin 0.253479
CXCL11 chemokine (C-X-C motif) ligand 11 0.247501
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.245396
ADCY9 adenylate cyclase 9 0.245396
OCLN occludin 0.234225
TJP1 tight junction protein 1 0.233183
F3 coagulation factor III (thromboplastin, tissue factor) 0.230063
MMP10 matrix metallopeptidase 10 0.227988
ATR ATR serine/threonine kinase 0.226607
NBPF8 neuroblastoma breakpoint family, member 8 0.223165
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 0.219057
THBS1 thrombospondin 1 0.218715
NRP1 neuropilin 1 0.216672
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.210253
NOS2 nitric oxide synthase 2, inducible 0.205254
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.203604
CARD9 caspase recruitment domain family, member 9 0.19742
SEBOX SEBOX homeobox 0.196779
ARG2 arginase 2 0.196779
IFI16 interferon, gamma-inducible protein 16 0.196779
IRF8 interferon regulatory factor 8 0.19582
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.194232
SATB2 SATB homeobox 2 0.192971
MYO5A myosin VA (heavy chain 12, myoxin) 0.190168
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.189859
CCL5 chemokine (C-C motif) ligand 5 0.186811
MMP3 matrix metallopeptidase 3 0.181798
RD3 retinal degeneration 3 0.181222
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.175947
GSTO1 glutathione S-transferase omega 1 0.174881
CCR2 chemokine (C-C motif) receptor 2 0.173571
CLU clusterin 0.172038
CNR2 cannabinoid receptor 2 (macrophage) 0.172038
ASL argininosuccinate lyase 0.171535
VCL vinculin 0.170054
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 0.16933
HM13 histocompatibility (minor) 13 0.162707
RAG2 recombination activating gene 2 0.162505