cerebral amyloid angiopathy Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description An amyloidosis where amyloid protein progressively deposits in cerebral blood vessel walls with subsequent degenerative vascular changes that usually result in spontaneous cerebral hemorrhage, ischemic lesions and progressive dementia. (Human Disease Ontology, DOID_9246)
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Genes

103 genes co-occuring with the disease cerebral amyloid angiopathy in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
APOE apolipoprotein E 2.22766
CST3 cystatin C 1.99918
ITM2B integral membrane protein 2B 1.78939
APP amyloid beta (A4) precursor protein 1.63142
ABRA actin binding Rho activating protein 1.51457
ERCC6L excision repair cross-complementation group 6-like 1.3433
GSN gelsolin 1.33981
PRNP prion protein 1.32847
PSEN1 presenilin 1 1.31231
HSPB2 heat shock 27kDa protein 2 1.2909
PPP1R12A protein phosphatase 1, regulatory subunit 12A 1.27737
TTR transthyretin 1.23386
MME membrane metallo-endopeptidase 1.14136
KCNMB2 potassium channel subfamily M regulatory beta subunit 2 1.08999
CSTB cystatin B (stefin B) 1.08076
LDLR low density lipoprotein receptor 0.967083
ZCWPW1 zinc finger, CW type with PWWP domain 1 0.791721
MYOCD myocardin 0.791721
AOC2 amine oxidase, copper containing 2 (retina-specific) 0.784755
HSPB8 heat shock 22kDa protein 8 0.752492
IDE insulin-degrading enzyme 0.721673
GABPA GA binding protein transcription factor, alpha subunit 60kDa 0.714811
COLEC12 collectin sub-family member 12 0.693098
CHI3L2 chitinase 3-like 2 0.678302
MAPT microtubule-associated protein tau 0.676308
PTPRM protein tyrosine phosphatase, receptor type, M 0.67551
MBTPS2 membrane-bound transcription factor peptidase, site 2 0.674713
AGER advanced glycosylation end product-specific receptor 0.657234
SLC30A3 solute carrier family 30 (zinc transporter), member 3 0.595623
CASS4 Cas scaffolding protein family member 4 0.592116
APCS amyloid P component, serum 0.571495
CLDN5 claudin 5 0.565277
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 0.560616
SDC2 syndecan 2 0.559839
AOC3 amine oxidase, copper containing 3 0.548971
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A 0.538506
BACE1 beta-site APP-cleaving enzyme 1 0.51611
OCLN occludin 0.508041
LARGE like-glycosyltransferase 0.502675
MIXL1 Mix paired-like homeobox 0.491215
NOTCH3 notch 3 0.490454
PLAT plasminogen activator, tissue 0.486646
MMP2 matrix metallopeptidase 2 0.482084
CST6 cystatin E/M 0.478289
MMEL1 membrane metallo-endopeptidase-like 1 0.476393
A2M alpha-2-macroglobulin 0.476014
NOTCH4 notch 4 0.461261
C3 complement component 3 0.452208
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.450701
ECE2 endothelin converting enzyme 2 0.445805
EZR ezrin 0.43753
CRYAB crystallin, alpha B 0.432646
NID2 nidogen 2 (osteonidogen) 0.424389
NOTO notochord homeobox 0.42289
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.414276
NOS3 nitric oxide synthase 3 (endothelial cell) 0.400826
C1QTNF5 C1q and tumor necrosis factor related protein 5 0.379997
ATP5J ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6 0.377773
MRC1 mannose receptor, C type 1 0.376661
MEOX2 mesenchyme homeobox 2 0.37629
AQP1 aquaporin 1 (Colton blood group) 0.369997
MMP19 matrix metallopeptidase 19 0.363347
C1QB complement component 1, q subcomponent, B chain 0.360395
CASP5 caspase 5, apoptosis-related cysteine peptidase 0.355604
ACTA1 actin, alpha 1, skeletal muscle 0.355235
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 0.354131
POLB polymerase (DNA directed), beta 0.353763
CD44 CD44 molecule (Indian blood group) 0.349717
TJP1 tight junction protein 1 0.349349
MMP26 matrix metallopeptidase 26 0.344207
DAD1 defender against cell death 1 0.331391
LGMN legumain 0.327375
GPC1 glypican 1 0.324823
RETNLB resistin like beta 0.321909
FURIN furin (paired basic amino acid cleaving enzyme) 0.299452
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 0.295492
GSTO1 glutathione S-transferase omega 1 0.294053
TXNDC9 thioredoxin domain containing 9 0.286519
TMSB10 thymosin beta 10 0.28151
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 0.267267
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 0.264077
CLU clusterin 0.258417
TGFB1 transforming growth factor, beta 1 0.258417
AIF1 allograft inflammatory factor 1 0.254888
CA4 carbonic anhydrase IV 0.248905
AQP4 aquaporin 4 0.243295
CD40LG CD40 ligand 0.242595
SCARB1 scavenger receptor class B, member 1 0.233878
MMP9 matrix metallopeptidase 9 0.230409
BDKRB1 bradykinin receptor B1 0.230409
PTK2B protein tyrosine kinase 2 beta 0.205585
ENDOG endonuclease G 0.200331
CST4 cystatin S 0.198386
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4 0.185016
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.17952
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13 0.178403
NME1 NME/NM23 nucleoside diphosphate kinase 1 0.178126
CD68 CD68 molecule 0.174881
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 0.16933
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 0.167682
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 0.166319
CAV2 caveolin 2 0.163317
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.157602