cell leading edge Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description The area of a motile cell closest to the direction of movement. (Gene Ontology, GO_0031252)
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Genes

279 proteins localized to the cell leading edge cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
SNX9 sorting nexin 9 0.663342
SH3RF1 SH3 domain containing ring finger 1 0.663342
PKN2 protein kinase N2 0.663342
FERMT1 fermitin family member 1 0.663342
MCC mutated in colorectal cancers 0.663342
S100A6 S100 calcium binding protein A6 0.663342
WWC1 WW and C2 domain containing 1 0.663342
PARD6A par-6 family cell polarity regulator alpha 0.663342
RAB3IP RAB3A interacting protein 0.663342
SLC39A6 solute carrier family 39 (zinc transporter), member 6 0.663342
CORO1A coronin, actin binding protein, 1A 0.663342
WASF2 WAS protein family, member 2 0.663342
NF2 neurofibromin 2 (merlin) 0.663342
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.663342
NME1 NME/NM23 nucleoside diphosphate kinase 1 0.663342
NME1-NME2 NME1-NME2 readthrough 0.663342
CDC42 cell division cycle 42 0.663342
MACF1 microtubule-actin crosslinking factor 1 0.663342
SNX5 sorting nexin 5 0.663342
SNAP25 synaptosomal-associated protein, 25kDa 0.663342
C2CD5 C2 calcium-dependent domain containing 5 0.663342
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.663342
INPP5K inositol polyphosphate-5-phosphatase K 0.663342
INPP5J inositol polyphosphate-5-phosphatase J 0.663342
KIF18A kinesin family member 18A 0.663342
PTK6 protein tyrosine kinase 6 0.663342
JMY junction mediating and regulatory protein, p53 cofactor 0.663342
CIB1 calcium and integrin binding 1 (calmyrin) 0.663342
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 0.663342
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.663342
TSC1 tuberous sclerosis 1 0.663342
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.663342
SH3YL1 SH3 and SYLF domain containing 1 0.663342
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.663342
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.663342
ITGB1BP1 integrin beta 1 binding protein 1 0.663342
MYLK myosin light chain kinase 0.663342
SNTG1 syntrophin, gamma 1 0.663342
SSH1 slingshot protein phosphatase 1 0.663342
DGKZ diacylglycerol kinase, zeta 0.663342
CLASP2 cytoplasmic linker associated protein 2 0.663342
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 0.663342
PPP1R9B protein phosphatase 1, regulatory subunit 9B 0.663342
PDE4A phosphodiesterase 4A, cAMP-specific 0.663342
PTK2B protein tyrosine kinase 2 beta 0.663342
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 0.663342
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 0.663342
PALLD palladin, cytoskeletal associated protein 0.663342
PLEK2 pleckstrin 2 0.663342
MTMR14 myotubularin related protein 14 0.663342
S100B S100 calcium binding protein B 0.663342
MTSS1 metastasis suppressor 1 0.663342
CDC42BPG CDC42 binding protein kinase gamma (DMPK-like) 0.663342
AMOT angiomotin 0.663342
VASP vasodilator-stimulated phosphoprotein 0.663342
MYO5A myosin VA (heavy chain 12, myoxin) 0.663342
PARVB parvin, beta 0.663342
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.663342
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma 0.663342
MYH9 myosin, heavy chain 9, non-muscle 0.663342
STMN2 stathmin 2 0.663342
DPP4 dipeptidyl-peptidase 4 0.663342
RPS3 ribosomal protein S3 0.663342
MYO6 myosin VI 0.663342
FAP fibroblast activation protein, alpha 0.663342
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 0.663342
PTPRK protein tyrosine phosphatase, receptor type, K 0.663342
PTPRM protein tyrosine phosphatase, receptor type, M 0.663342
CD2AP CD2-associated protein 0.663342
BCAR1 breast cancer anti-estrogen resistance 1 0.663342
CCDC88A coiled-coil domain containing 88A 0.663342
ADGRE2 adhesion G protein-coupled receptor E2 0.663342
INPPL1 inositol polyphosphate phosphatase-like 1 0.663342
PDE9A phosphodiesterase 9A 0.663342
ARF6 ADP-ribosylation factor 6 0.663342
CLIP1 CAP-GLY domain containing linker protein 1 0.663342
PODXL podocalyxin-like 0.663342
SCIMP SLP adaptor and CSK interacting membrane protein 0.663342
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.663342
CDK6 cyclin-dependent kinase 6 0.663342
SCYL3 SCY1-like 3 (S. cerevisiae) 0.663342
AMPH amphiphysin 0.663342
WASH1 WAS protein family homolog 1 0.663342
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.663342
PLCG1 phospholipase C, gamma 1 0.663342
SYNE1 spectrin repeat containing, nuclear envelope 1 0.663342
AIF1 allograft inflammatory factor 1 0.663342
CXCR4 chemokine (C-X-C motif) receptor 4 0.663342
ABLIM3 actin binding LIM protein family, member 3 0.663342
ABLIM1 actin binding LIM protein 1 0.663342
EZR ezrin 0.663342
ANTXR1 anthrax toxin receptor 1 0.663342
BAIAP2 BAI1-associated protein 2 0.663342
BMX BMX non-receptor tyrosine kinase 0.663342
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 0.663342
CLRN1 clarin 1 0.663342
TESC tescalcin 0.663342
SCRIB scribbled planar cell polarity protein 0.663342
SYNE2 spectrin repeat containing, nuclear envelope 2 0.663342
ITGB4 integrin, beta 4 0.663342
S100A11 S100 calcium binding protein A11 0.663342
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.663342
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.663342
EPHA2 EPH receptor A2 0.663342
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.663342
APC adenomatous polyposis coli 0.663342
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 0.663342
DST dystonin 0.663342
SPATA13 spermatogenesis associated 13 0.663342
ARHGAP44 Rho GTPase activating protein 44 0.663342
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.663342
DIAPH1 diaphanous-related formin 1 0.663342
ITGAV integrin, alpha V 0.663342
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.663342
ITSN1 intersectin 1 (SH3 domain protein) 0.663342
MEFV Mediterranean fever 0.663342
ABI2 abl-interactor 2 0.663342
ABI3 ABI family, member 3 0.663342
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.663342
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.663342
ABI1 abl-interactor 1 0.663342
KANK1 KN motif and ankyrin repeat domains 1 0.663342
VIL1 villin 1 0.663342
MTM1 myotubularin 1 0.663342
FGD6 FYVE, RhoGEF and PH domain containing 6 0.237908
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.237908
FGD1 FYVE, RhoGEF and PH domain containing 1 0.237908
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.237908
FGD2 FYVE, RhoGEF and PH domain containing 2 0.237908
EVL Enah/Vasp-like 0.237908
CNTNAP2 contactin associated protein-like 2 0.237908
FGD3 FYVE, RhoGEF and PH domain containing 3 0.237908
EPS8 epidermal growth factor receptor pathway substrate 8 0.237908
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.237908
EPS8L2 EPS8-like 2 0.237908
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 0.237908
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.237908
FGD5 FYVE, RhoGEF and PH domain containing 5 0.237908
CORO1B coronin, actin binding protein, 1B 0.237908
EPS8L1 EPS8-like 1 0.237908
SHISA9 shisa family member 9 0.237908
RAB13 RAB13, member RAS oncogene family 0.237908
ARPIN actin-related protein 2/3 complex inhibitor 0.237908
MYADM myeloid-associated differentiation marker 0.237908
FGD4 FYVE, RhoGEF and PH domain containing 4 0.237908
TPM1 tropomyosin 1 (alpha) 0.237908
PLEK pleckstrin 0.237908
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 0.237908
AAK1 AP2 associated kinase 1 0.237908
ARFIP2 ADP-ribosylation factor interacting protein 2 0.237908
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 0.237908
CYFIP1 cytoplasmic FMR1 interacting protein 1 0.237908
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.237908
BCAS3 breast carcinoma amplified sequence 3 0.237908
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.237908
LAMP5 lysosomal-associated membrane protein family, member 5 0.237908
LRRC16A leucine rich repeat containing 16A 0.237908
PHACTR4 phosphatase and actin regulator 4 0.237908
PLXND1 plexin D1 0.237908
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.237908
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 0.237908
PXN paxillin 0.237908
ALS2 amyotrophic lateral sclerosis 2 (juvenile) 0.237908
RHOA ras homolog family member A 0.237908
HDAC6 histone deacetylase 6 0.237908
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 0.237908
PTPRO protein tyrosine phosphatase, receptor type, O 0.237908
DBNL drebrin-like 0.237908
APC2 adenomatosis polyposis coli 2 0.237908
ARF4 ADP-ribosylation factor 4 0.237908
DPYSL3 dihydropyrimidinase-like 3 0.237908
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.237908
PDPN podoplanin 0.237908
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.237908
RINL Ras and Rab interactor-like 0.237908
SGCE sarcoglycan, epsilon 0.237908
CTTN cortactin 0.237908
GPER1 G protein-coupled estrogen receptor 1 0.237908
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.098109
COBL cordon-bleu WH2 repeat protein 0.098109
FZD1 frizzled class receptor 1 0.098109
SPTBN1 spectrin, beta, non-erythrocytic 1 0.098109
FZD2 frizzled class receptor 2 0.098109
LAYN layilin 0.098109
TRPV4 transient receptor potential cation channel, subfamily V, member 4 0.098109
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.098109
FZD3 frizzled class receptor 3 0.098109
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 0.098109
TLN1 talin 1 0.098109
TWF2 twinfilin actin binding protein 2 0.098109
LCP1 lymphocyte cytosolic protein 1 (L-plastin) 0.098109
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 0.098109
FZD6 frizzled class receptor 6 0.098109
FZD7 frizzled class receptor 7 0.098109
HAX1 HCLS1 associated protein X-1 0.098109
TACR3 tachykinin receptor 3 0.03318
SH2B2 SH2B adaptor protein 2 0.03318
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3 0.03318
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 0.03318
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.03318
PRKCZ protein kinase C, zeta 0.03318
GSN gelsolin 0.03318
ILK integrin-linked kinase 0.03318
CYTH3 cytohesin 3 0.03318
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein 0.03318
ANK1 ankyrin 1, erythrocytic 0.03318
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.03318
TLN2 talin 2 0.03318
GABARAPL1 GABA(A) receptor-associated protein like 1 0.03318
WASL Wiskott-Aldrich syndrome-like 0.03318
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.03318
PLA2G4F phospholipase A2, group IVF 0.03318
TWF1 twinfilin actin binding protein 1 0.03318
NDEL1 nudE neurodevelopment protein 1-like 1 0.03318
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.03318
EPB41L5 erythrocyte membrane protein band 4.1 like 5 0.03318
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.03318
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 0.03318
CTNND1 catenin (cadherin-associated protein), delta 1 0.03318
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.03318
PARVA parvin, alpha 0.03318
CDC37 cell division cycle 37 0.03318
DYSF dysferlin 0.03318
CAPZB capping protein (actin filament) muscle Z-line, beta 0.03318
ANXA2 annexin A2 0.03318
NCKAP1 NCK-associated protein 1 0.03318
IQGAP1 IQ motif containing GTPase activating protein 1 0.03318
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 0.03318
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.03318
CDKL5 cyclin-dependent kinase-like 5 0.03318
FRMD4B FERM domain containing 4B 0.03318
CDK5 cyclin-dependent kinase 5 0.03318
PRKCI protein kinase C, iota 0.03318
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1 0.03318
AMOTL1 angiomotin like 1 0.03318
WASF1 WAS protein family, member 1 0.03318
ATF4 activating transcription factor 4 0.03318
PALM paralemmin 0.03318
CIT citron rho-interacting serine/threonine kinase 0.03318
ENAH enabled homolog (Drosophila) 0.03318
ADORA1 adenosine A1 receptor 0.03318
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.03318
FGR FGR proto-oncogene, Src family tyrosine kinase 0.03318
AJUBA ajuba LIM protein 0.03318
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.03318
WASF3 WAS protein family, member 3 0.03318
PDLIM7 PDZ and LIM domain 7 (enigma) 0.03318
OPRD1 opioid receptor, delta 1 0.03318
KDF1 keratinocyte differentiation factor 1 0.03318
RAB5A RAB5A, member RAS oncogene family 0.03318
ARHGAP31 Rho GTPase activating protein 31 0.03318
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.03318
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.03318
SRA1 steroid receptor RNA activator 1 0.03318
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.03318
CFL1 cofilin 1 (non-muscle) 0.03318
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.03318
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.03318
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 0.03318
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.03318
DOCK8 dedicator of cytokinesis 8 0.03318
GAS7 growth arrest-specific 7 0.03318
ARHGAP1 Rho GTPase activating protein 1 0.03318
ITGA8 integrin, alpha 8 0.03318
BSPRY B-box and SPRY domain containing 0.03318
MYO9B myosin IXB 0.03318
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 0.03318
DCTN1 dynactin 1 0.03318
VIM vimentin 0.03318
MCF2L MCF.2 cell line derived transforming sequence-like 0.03318
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 0.03318
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.03318
PTK2 protein tyrosine kinase 2 0.03318
ITGB5 integrin, beta 5 0.03318
MYO1D myosin ID 0.03318
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.03318
TUBG1 tubulin, gamma 1 0.03318
RDX radixin 0.03318
FAT1 FAT atypical cadherin 1 0.03318