cefuroxime-6088 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the cefuroxime-6088 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
AHSP alpha hemoglobin stabilizing protein
AIM1L absent in melanoma 1-like
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ATF7IP activating transcription factor 7 interacting protein
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BRS3 bombesin-like receptor 3
C3 complement component 3
CA10 carbonic anhydrase X
CAV2 caveolin 2
CCL22 chemokine (C-C motif) ligand 22
CFAP70 cilia and flagella associated protein 70
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric)
CLEC1A C-type lectin domain family 1, member A
CNTN5 contactin 5
COL13A1 collagen, type XIII, alpha 1
CPED1 cadherin-like and PC-esterase domain containing 1
CTNNA2 catenin (cadherin-associated protein), alpha 2
CTSS cathepsin S
DLK1 delta-like 1 homolog (Drosophila)
DSCC1 DNA replication and sister chromatid cohesion 1
DST dystonin
DUSP1 dual specificity phosphatase 1
EGR4 early growth response 4
EXOSC2 exosome component 2
EYA3 EYA transcriptional coactivator and phosphatase 3
FFAR2 free fatty acid receptor 2
FYN FYN proto-oncogene, Src family tyrosine kinase
GBP2 guanylate binding protein 2, interferon-inducible
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2
GM2A GM2 ganglioside activator
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPM6A glycoprotein M6A
GPR176 G protein-coupled receptor 176
GRIA3 glutamate receptor, ionotropic, AMPA 3
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GSTTP1 glutathione S-transferase theta pseudogene 1
HBB hemoglobin, beta
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HIST1H2BO histone cluster 1, H2bo
HOXC4 homeobox C4
IGHM immunoglobulin heavy constant mu
IGLJ3 immunoglobulin lambda joining 3
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KHK ketohexokinase (fructokinase)
LAMB4 laminin, beta 4
LEFTY2 left-right determination factor 2
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LOC157562 uncharacterized LOC157562
LRRC32 leucine rich repeat containing 32
LTBP4 latent transforming growth factor beta binding protein 4
MAGEA6 melanoma antigen family A6
MUC4 mucin 4, cell surface associated
N4BP2L1 NEDD4 binding protein 2-like 1
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NAT6 N-acetyltransferase 6 (GCN5-related)
NOV nephroblastoma overexpressed
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
OR3A3 olfactory receptor, family 3, subfamily A, member 3
PCDHGA11 protocadherin gamma subfamily A, 11
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLD1 phospholipase D1, phosphatidylcholine-specific
POU6F1 POU class 6 homeobox 1
PRUNE2 prune homolog 2 (Drosophila)
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RGS12 regulator of G-protein signaling 12
RNF17 ring finger protein 17
RUNDC3A RUN domain containing 3A
SAYSD1 SAYSVFN motif domain containing 1
SERGEF secretion regulating guanine nucleotide exchange factor
SERHL2 serine hydrolase-like 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIPA1 signal-induced proliferation-associated 1
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC17A4 solute carrier family 17, member 4
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SNTA1 syntrophin, alpha 1
SOCS3 suppressor of cytokine signaling 3
SP100 SP100 nuclear antigen
SPINK5 serine peptidase inhibitor, Kazal type 5
SRCAP Snf2-related CREBBP activator protein
SULT4A1 sulfotransferase family 4A, member 1
SYNDIG1 synapse differentiation inducing 1
TAS2R1 taste receptor, type 2, member 1
TBC1D2 TBC1 domain family, member 2
THBS3 thrombospondin 3
TM4SF5 transmembrane 4 L six family member 5
TMPRSS5 transmembrane protease, serine 5
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TP63 tumor protein p63
TRBC1 T cell receptor beta constant 1
ZFP64 ZFP64 zinc finger protein

decreased expression

Symbol Name
AGMAT agmatine ureohydrolase (agmatinase)
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ARMC4 armadillo repeat containing 4
ASPHD1 aspartate beta-hydroxylase domain containing 1
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BMP4 bone morphogenetic protein 4
C14ORF93 chromosome 14 open reading frame 93
C22ORF29 chromosome 22 open reading frame 29
C4ORF29 chromosome 4 open reading frame 29
C7ORF43 chromosome 7 open reading frame 43
CAPRIN2 caprin family member 2
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCDC176 coiled-coil domain containing 176
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CD82 CD82 molecule
CD83 CD83 molecule
CEP97 centrosomal protein 97kDa
CHKB choline kinase beta
CLCF1 cardiotrophin-like cytokine factor 1
CRABP1 cellular retinoic acid binding protein 1
CRYBB2P1 crystallin, beta B2 pseudogene 1
CSF1R colony stimulating factor 1 receptor
DGAT1 diacylglycerol O-acyltransferase 1
DUSP9 dual specificity phosphatase 9
DYSF dysferlin
EAF2 ELL associated factor 2
EDAR ectodysplasin A receptor
EFNA4 ephrin-A4
EHMT1 euchromatic histone-lysine N-methyltransferase 1
F2R coagulation factor II (thrombin) receptor
FOXN2 forkhead box N2
GADD45G growth arrest and DNA-damage-inducible, gamma
GALT galactose-1-phosphate uridylyltransferase
GMPR guanosine monophosphate reductase
GRAMD4 GRAM domain containing 4
GTPBP2 GTP binding protein 2
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H2BC histone cluster 1, H2bc
HOXA4 homeobox A4
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
IQSEC2 IQ motif and Sec7 domain 2
IRF6 interferon regulatory factor 6
KAT2A K(lysine) acetyltransferase 2A
KREMEN2 kringle containing transmembrane protein 2
KRT13 keratin 13, type I
LIN7A lin-7 homolog A (C. elegans)
LINS lines homolog (Drosophila)
LRRC37A3 leucine rich repeat containing 37, member A3
LRRC61 leucine rich repeat containing 61
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAST3 microtubule associated serine/threonine kinase 3
MSI1 musashi RNA-binding protein 1
MUM1 melanoma associated antigen (mutated) 1
MVP major vault protein
N4BP3 NEDD4 binding protein 3
NPIPB15 nuclear pore complex interacting protein family, member B15
OR1D2 olfactory receptor, family 1, subfamily D, member 2
PADI2 peptidyl arginine deiminase, type II
PLD2 phospholipase D2
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PTK6 protein tyrosine kinase 6
PTPN9 protein tyrosine phosphatase, non-receptor type 9
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
PTPRE protein tyrosine phosphatase, receptor type, E
PVRL3 poliovirus receptor-related 3
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RNF2 ring finger protein 2
RPAP1 RNA polymerase II associated protein 1
RPGR retinitis pigmentosa GTPase regulator
S100A2 S100 calcium binding protein A2
SCAI suppressor of cancer cell invasion
SCN1B sodium channel, voltage gated, type I beta subunit
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC12A8 solute carrier family 12, member 8
SLC38A10 solute carrier family 38, member 10
SLC46A3 solute carrier family 46, member 3
SLMO1 slowmo homolog 1 (Drosophila)
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
TESC tescalcin
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGFBR1 transforming growth factor, beta receptor 1
TMEM209 transmembrane protein 209
TRAF2 TNF receptor-associated factor 2
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TTC30A tetratricopeptide repeat domain 30A
USB1 U6 snRNA biogenesis 1
WLS wntless Wnt ligand secretion mediator
YEATS2 YEATS domain containing 2
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZNF10 zinc finger protein 10
ZNF428 zinc finger protein 428
ZNF492 zinc finger protein 492
ZNF516 zinc finger protein 516
ZNF551 zinc finger protein 551
ZNF768 zinc finger protein 768
ZNF770 zinc finger protein 770