cefalexin-4654 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the cefalexin-4654 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTN2 actinin, alpha 2
ADCY9 adenylate cyclase 9
AIM2 absent in melanoma 2
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
AKAP5 A kinase (PRKA) anchor protein 5
ALPI alkaline phosphatase, intestinal
ANGPTL2 angiopoietin-like 2
ARNT aryl hydrocarbon receptor nuclear translocator
ASIC4 acid sensing (proton gated) ion channel family member 4
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
CACYBP calcyclin binding protein
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CCDC186 coiled-coil domain containing 186
CCDC87 coiled-coil domain containing 87
CDC42 cell division cycle 42
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHGB chromogranin B
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CLCN7 chloride channel, voltage-sensitive 7
COMP cartilage oligomeric matrix protein
CRP C-reactive protein, pentraxin-related
CSHL1 chorionic somatomammotropin hormone-like 1
CTIF CBP80/20-dependent translation initiation factor
CYTH3 cytohesin 3
DIRAS3 DIRAS family, GTP-binding RAS-like 3
FAM63B family with sequence similarity 63, member B
FFAR2 free fatty acid receptor 2
FGFR1 fibroblast growth factor receptor 1
FILIP1L filamin A interacting protein 1-like
FYN FYN proto-oncogene, Src family tyrosine kinase
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GPSM3 G-protein signaling modulator 3
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
ICOS inducible T-cell co-stimulator
IFNA14 interferon, alpha 14
IL11 interleukin 11
INHBE inhibin, beta E
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KDM6B lysine (K)-specific demethylase 6B
LCAT lecithin-cholesterol acyltransferase
LIMK2 LIM domain kinase 2
LRTM1 leucine-rich repeats and transmembrane domains 1
MCTP2 multiple C2 domains, transmembrane 2
MRPL20 mitochondrial ribosomal protein L20
MVB12B multivesicular body subunit 12B
MVD mevalonate (diphospho) decarboxylase
MYL10 myosin, light chain 10, regulatory
NCALD neurocalcin delta
NPR1 natriuretic peptide receptor 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRG1 neuregulin 1
NRP2 neuropilin 2
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OMD osteomodulin
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PBOV1 prostate and breast cancer overexpressed 1
PCDHB13 protocadherin beta 13
PCDHGA10 protocadherin gamma subfamily A, 10
PHF7 PHD finger protein 7
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRDM2 PR domain containing 2, with ZNF domain
PRKCA protein kinase C, alpha
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RBBP4 retinoblastoma binding protein 4
RGS11 regulator of G-protein signaling 11
RIMS2 regulating synaptic membrane exocytosis 2
RPL10L ribosomal protein L10-like
RPL23AP32 ribosomal protein L23a pseudogene 32
RPL35A ribosomal protein L35a
RPS14 ribosomal protein S14
SAMD4A sterile alpha motif domain containing 4A
SCAMP1 secretory carrier membrane protein 1
SCN11A sodium channel, voltage gated, type XI alpha subunit
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SLC16A6 solute carrier family 16, member 6
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SMAD1 SMAD family member 1
SUGP1 SURP and G patch domain containing 1
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TAOK3 TAO kinase 3
TAS2R1 taste receptor, type 2, member 1
TBX2 T-box 2
TLN2 talin 2
TRD T cell receptor delta locus
TRIM10 tripartite motif containing 10
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
WSB1 WD repeat and SOCS box containing 1
XCR1 chemokine (C motif) receptor 1
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZIC3 Zic family member 3
ZNF277 zinc finger protein 277
ZNF93 zinc finger protein 93

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ADCY6 adenylate cyclase 6
AFAP1 actin filament associated protein 1
AFF4 AF4/FMR2 family, member 4
ALPK1 alpha-kinase 1
ANP32A-IT1 ANP32A intronic transcript 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATAD5 ATPase family, AAA domain containing 5
BAG4 BCL2-associated athanogene 4
C14ORF105 chromosome 14 open reading frame 105
C14ORF79 chromosome 14 open reading frame 79
C22ORF46 chromosome 22 open reading frame 46
C9ORF40 chromosome 9 open reading frame 40
CA11 carbonic anhydrase XI
CAMTA2 calmodulin binding transcription activator 2
CASD1 CAS1 domain containing 1
CBX8 chromobox homolog 8
CCDC106 coiled-coil domain containing 106
CCDC88C coiled-coil domain containing 88C
CCNJ cyclin J
CD79A CD79a molecule, immunoglobulin-associated alpha
CEL carboxyl ester lipase
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRDL1 chordin-like 1
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNN1 calponin 1, basic, smooth muscle
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
ELP3 elongator acetyltransferase complex subunit 3
EYA4 EYA transcriptional coactivator and phosphatase 4
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
GPR27 G protein-coupled receptor 27
GREM1 gremlin 1, DAN family BMP antagonist
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
GTPBP6 GTP binding protein 6 (putative)
HIST1H2BO histone cluster 1, H2bo
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HYAL3 hyaluronoglucosaminidase 3
IFT140 intraflagellar transport 140
IMPAD1 inositol monophosphatase domain containing 1
INADL InaD-like (Drosophila)
IQCG IQ motif containing G
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KRT20 keratin 20, type I
LHFPL2 lipoma HMGIC fusion partner-like 2
LIG4 ligase IV, DNA, ATP-dependent
LOC157562 uncharacterized LOC157562
MANBA mannosidase, beta A, lysosomal
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MCC mutated in colorectal cancers
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MRPL44 mitochondrial ribosomal protein L44
MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
NDE1 nudE neurodevelopment protein 1
NTF3 neurotrophin 3
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PADI1 peptidyl arginine deiminase, type I
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLCD1 phospholipase C, delta 1
PPT2 palmitoyl-protein thioesterase 2
PWAR5 Prader Willi/Angelman region RNA 5
RNF126P1 ring finger protein 126 pseudogene 1
RNF2 ring finger protein 2
ROM1 retinal outer segment membrane protein 1
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC25A40 solute carrier family 25, member 40
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SSBP3 single stranded DNA binding protein 3
SYT17 synaptotagmin XVII
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TEX40 testis expressed 40
TMEM212 transmembrane protein 212
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TTLL7 tubulin tyrosine ligase-like family member 7
YOD1 YOD1 deubiquitinase
YY2 YY2 transcription factor
ZNF141 zinc finger protein 141
ZNF197 zinc finger protein 197
ZNF41 zinc finger protein 41
ZNF528 zinc finger protein 528
ZNF529 zinc finger protein 529
ZNF611 zinc finger protein 611
ZNF675 zinc finger protein 675
ZNF702P zinc finger protein 702, pseudogene
ZNF76 zinc finger protein 76
ZNF778 zinc finger protein 778
ZSCAN2 zinc finger and SCAN domain containing 2