cataract Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Partial or complete opacity of the crystalline lens of one or both eyes that decreases visual acuity and eventually results in blindness. Some cataracts appear in infancy or in childhood, but most develop in older individuals. (Sternberg Diagnostic Surgical Pathology, 3rd ed.)|Partial or complete opacity of the crystalline lens of one or both eyes that decreases visual acuity and eventually results in blindness. Some cataracts appear in infancy or in childhood, but most develop in older individuals. (Sternberg Diagnostic Surgical Pathology, 3rd ed.)|Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed) (Experimental Factor Ontology, EFO_0001059)
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Genes

91 genes co-occuring with the biological term cataract in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABHD12 abhydrolase domain containing 12
ADAM9 ADAM metallopeptidase domain 9
AGK acylglycerol kinase
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOE apolipoprotein E
BCL2 B-cell CLL/lymphoma 2
BFSP1 beaded filament structural protein 1, filensin
BFSP2 beaded filament structural protein 2, phakinin
BLM Bloom syndrome, RecQ helicase-like
CAT catalase
COL4A1 collagen, type IV, alpha 1
CRYAA crystallin, alpha A
CRYAB crystallin, alpha B
CRYBA1 crystallin, beta A1
CRYBA2 crystallin, beta A2
CRYBA4 crystallin, beta A4
CRYBB1 crystallin, beta B1
CRYBB2 crystallin, beta B2
CRYGA crystallin, gamma A
CRYGB crystallin, gamma B
CRYGC crystallin, gamma C
CRYGD crystallin, gamma D
CRYGS crystallin, gamma S
CTNND2 catenin (cadherin-associated protein), delta 2
DMBX1 diencephalon/mesencephalon homeobox 1
EPHA2 EPH receptor A2
ERCC2 excision repair cross-complementation group 2
ERCC6 excision repair cross-complementation group 6
FAM126A family with sequence similarity 126, member A
FN1 fibronectin 1
FOXE3 forkhead box E3
FTL ferritin, light polypeptide
G6PD glucose-6-phosphate dehydrogenase
GALK1 galactokinase 1
GALT galactose-1-phosphate uridylyltransferase
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GJA3 gap junction protein, alpha 3, 46kDa
GJA8 gap junction protein, alpha 8, 50kDa
GPX1 glutathione peroxidase 1
GSTM1 glutathione S-transferase mu 1
GSTO2 glutathione S-transferase omega 2
GSTT1 glutathione S-transferase theta 1
HSF4 heat shock transcription factor 4
HSPA1B heat shock 70kDa protein 1B
ICAM1 intercellular adhesion molecule 1
IDO1 indoleamine 2,3-dioxygenase 1
KEAP1 kelch-like ECH-associated protein 1
KLC1 kinesin light chain 1
LCT lactase
LIM2 lens intrinsic membrane protein 2, 19kDa
LMNA lamin A/C
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MIP major intrinsic protein of lens fiber
MIR184 microRNA 184
MSRA methionine sulfoxide reductase A
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYH6 myosin, heavy chain 6, cardiac muscle, alpha
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NDRG2 NDRG family member 2
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies)
NXNL1 nucleoredoxin-like 1
OGG1 8-oxoguanine DNA glycosylase
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PAX6 paired box 6
PCNA proliferating cell nuclear antigen
PITX3 paired-like homeodomain 3
PON1 paraoxonase 1
PRDX3 peroxiredoxin 3
PXDN peroxidasin
RGS6 regulator of G-protein signaling 6
SELE selectin E
SELL selectin L
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SIRT1 sirtuin 1
SLC16A12 solute carrier family 16, member 12
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SOD3 superoxide dismutase 3, extracellular
TDRD7 tudor domain containing 7
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFB3 transforming growth factor, beta 3
TMEM114 transmembrane protein 114
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VIM vimentin
WFS1 Wolfram syndrome 1 (wolframin)
WRN Werner syndrome, RecQ helicase-like
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZEB2 zinc finger E-box binding homeobox 2