caries Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Localized destruction of the tooth surface initiated by decalcification of the enamel followed by enzymatic lysis of organic structures and leading to cavity formation. If left unchecked, the cavity may penetrate the enamel and dentin and reach the pulp. The three most prominent theories used to explain the etiology of the disease are that acids produced by bacteria lead to decalcification; that micro-organisms destroy the enamel protein; or that keratolytic micro-organisms produce chelates that lead to decalcification. (Experimental Factor Ontology, EFO_0003819)
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Genes

32 genes co-occuring with the biological term caries in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AJAP1 adherens junctions associated protein 1
AMELX amelogenin, X-linked
BTF3 basic transcription factor 3
CA4 carbonic anhydrase IV
CA6 carbonic anhydrase VI
CAMP cathelicidin antimicrobial peptide
CD14 CD14 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
DEFB1 defensin, beta 1
DSPP dentin sialophosphoprotein
ENAM enamelin
GJA1 gap junction protein, alpha 1, 43kDa
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HTN3 histatin 3
LPO lactoperoxidase
LTF lactotransferrin
LYZ lysozyme
LYZL2 lysozyme-like 2
MBL2 mannose-binding lectin (protein C) 2, soluble
MMP13 matrix metallopeptidase 13
MMP20 matrix metallopeptidase 20
MUC1 mucin 1, cell surface associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
MUC7 mucin 7, secreted
PDLIM7 PDZ and LIM domain 7 (enigma)
PRH1 proline-rich protein HaeIII subfamily 1
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2
TAS1R2 taste receptor, type 1, member 2
TAS2R38 taste receptor, type 2, member 38
TFIP11 tuftelin interacting protein 11
TIMP1 TIMP metallopeptidase inhibitor 1
TRAV4 T cell receptor alpha variable 4