cardiovascular cancer Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description An organ system cancer that located_in the heart and blood vessels. (Human Disease Ontology, DOID_176)
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Genes

205 genes co-occuring with the disease cardiovascular cancer in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
MLANA melan-A 1.81916
CD34 CD34 molecule 1.78849
HBA1 hemoglobin, alpha 1 1.74096
TFE3 transcription factor binding to IGHM enhancer 3 1.71864
HBA2 hemoglobin, alpha 2 1.71453
F8 coagulation factor VIII, procoagulant component 1.70861
CALD1 caldesmon 1 1.48165
CAMTA1 calmodulin binding transcription activator 1 1.38123
PTH1R parathyroid hormone 1 receptor 1.37032
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase 1.30183
WWTR1 WW domain containing transcription regulator 1 1.29833
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 1.1312
PROX1 prospero homeobox 1 1.10384
TSC2 tuberous sclerosis 2 1.069
FLT4 fms-related tyrosine kinase 4 1.01005
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.00752
PDPN podoplanin 0.996127
MITF microphthalmia-associated transcription factor 0.979268
SYP synaptophysin 0.879833
ENO2 enolase 2 (gamma, neuronal) 0.858134
SNRK SNF related kinase 0.846259
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 0.843802
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 0.825768
RHEB Ras homolog enriched in brain 0.825358
CTSK cathepsin K 0.767985
FGF2 fibroblast growth factor 2 (basic) 0.76431
CALB2 calbindin 2 0.759008
FLT1 fms-related tyrosine kinase 1 0.742329
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) 0.703134
ESAM endothelial cell adhesion molecule 0.697109
CD68 CD68 molecule 0.679898
AJUBA ajuba LIM protein 0.672324
TIAM2 T-cell lymphoma invasion and metastasis 2 0.672324
KDR kinase insert domain receptor 0.642221
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa 0.642221
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.633956
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.614356
TP53 tumor protein p53 0.605762
VWF von Willebrand factor 0.592895
S100A5 S100 calcium binding protein A5 0.585887
SMTN smoothelin 0.58005
ANO1 anoctamin 1, calcium activated chloride channel 0.566831
S100A3 S100 calcium binding protein A3 0.554403
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.551298
SLC35G5 solute carrier family 35, member G5 0.543155
HOXA3 homeobox A3 0.538893
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.530381
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) 0.528835
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein 0.523045
PLA2G12A phospholipase A2, group XIIA 0.521502
GLMN glomulin, FKBP associated protein 0.512264
VEGFA vascular endothelial growth factor A 0.511112
TYR tyrosinase 0.491215
EWSR1 EWS RNA-binding protein 1 0.482844
THBD thrombomodulin 0.474877
VEGFC vascular endothelial growth factor C 0.474877
ANGPT2 angiopoietin 2 0.465038
ENPEP glutamyl aminopeptidase (aminopeptidase A) 0.462394
HOXD3 homeobox D3 0.451454
CHGA chromogranin A 0.416896
STAB1 stabilin 1 0.410161
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.409414
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.397471
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 0.394491
ZFP36 ZFP36 ring finger protein 0.392629
TTK TTK protein kinase 0.388538
CDH5 cadherin 5, type 2 (vascular endothelium) 0.387423
PAX8 paired box 8 0.37592
MAML1 mastermind-like 1 (Drosophila) 0.36704
SOX10 SRY (sex determining region Y)-box 10 0.342372
RREB1 ras responsive element binding protein 1 0.33944
TAC1 tachykinin, precursor 1 0.32993
AQP9 aquaporin 9 0.317909
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) 0.312464
FLI1 Fli-1 proto-oncogene, ETS transcription factor 0.311377
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.309928
WT1 Wilms tumor 1 0.30848
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 0.306672
ANTXR1 anthrax toxin receptor 1 0.302337
CUL2 cullin 2 0.292257
ADORA2B adenosine A2b receptor 0.289386
ERF Ets2 repressor factor 0.281868
BID BH3 interacting domain death agonist 0.280082
CCND1 cyclin D1 0.27687
PGR progesterone receptor 0.272953
FES FES proto-oncogene, tyrosine kinase 0.259124
LTBP3 latent transforming growth factor beta binding protein 3 0.251718
ANPEP alanyl (membrane) aminopeptidase 0.251366
CALCA calcitonin-related polypeptide alpha 0.244696
GADD45A growth arrest and DNA-damage-inducible, alpha 0.242945
CTAG2 cancer/testis antigen 2 0.237357
PROM1 prominin 1 0.237009
PPARG peroxisome proliferator-activated receptor gamma 0.235964
RGS5 regulator of G-protein signaling 5 0.234225
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.233878
DES desmin 0.233183
PTPRJ protein tyrosine phosphatase, receptor type, J 0.230755
PMEL premelanosome protein 0.225229
LTBP2 latent transforming growth factor beta binding protein 2 0.218034
PLAU plasminogen activator, urokinase 0.217352
HES2 hes family bHLH transcription factor 2 0.215992
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.214636
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 0.212945
S100A1 S100 calcium binding protein A1 0.212271
GFAP glial fibrillary acidic protein 0.205916
HOXA5 homeobox A5 0.200006
ATF2 activating transcription factor 2 0.198709
SIX2 SIX homeobox 2 0.18472
ARNT aryl hydrocarbon receptor nuclear translocator 0.182375
ALPPL2 alkaline phosphatase, placental-like 2 0.182086
ALPP alkaline phosphatase, placental 0.181798
LAMA2 laminin, alpha 2 0.181798
ALPL alkaline phosphatase, liver/bone/kidney 0.18151
PTGER4 prostaglandin E receptor 4 (subtype EP4) 0.177301
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 0.176485
JAZF1 JAZF zinc finger 1 0.173057
SOX11 SRY (sex determining region Y)-box 11 0.168854
ELL elongation factor RNA polymerase II 0.166095
NF1 neurofibromin 1 0.165217
YAP1 Yes-associated protein 1 0.165001
KRT15 keratin 15, type I 0.160948
PIGF phosphatidylinositol glycan anchor biosynthesis, class F 0.15948
MMP9 matrix metallopeptidase 9 0.159302
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 0.158266
AFP alpha-fetoprotein 0.157602
MB myoglobin 0.140298
CD99 CD99 molecule 0.138922
TNNI3 troponin I type 3 (cardiac) 0.138875
PGLS 6-phosphogluconolactonase 0.136271
APOD apolipoprotein D 0.13601
PHF1 PHD finger protein 1 0.135425
MUC6 mucin 6, oligomeric mucus/gel-forming 0.135336
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.135179
WIPF2 WAS/WASL interacting protein family, member 2 0.134343
GRB2 growth factor receptor-bound protein 2 0.134076
CLEC3A C-type lectin domain family 3, member A 0.134044
CLEC2B C-type lectin domain family 2, member B 0.133856
PNMT phenylethanolamine N-methyltransferase 0.133054
NEFH neurofilament, heavy polypeptide 0.132961
CLEC10A C-type lectin domain family 10, member A 0.132951
NCAM1 neural cell adhesion molecule 1 0.131981
CLDN5 claudin 5 0.131263
KRT7 keratin 7, type II 0.131184
KRT14 keratin 14, type I 0.129632
KRT19 keratin 19, type I 0.127832
VIM vimentin 0.124574
BCL6 B-cell CLL/lymphoma 6 0.124564
PRCC papillary renal cell carcinoma (translocation-associated) 0.12387
CLTC clathrin, heavy chain (Hc) 0.121174
PAX2 paired box 2 0.120191
B3GAT1 beta-1,3-glucuronyltransferase 1 0.116893
NONO non-POU domain containing, octamer-binding 0.114695
TYRP1 tyrosinase-related protein 1 0.114232
S100P S100 calcium binding protein P 0.1141
MYH11 myosin, heavy chain 11, smooth muscle 0.112583
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.112091
S100A2 S100 calcium binding protein A2 0.111859
PDGFC platelet derived growth factor C 0.111841
TSC1 tuberous sclerosis 1 0.110598
AMD1 adenosylmethionine decarboxylase 1 0.109866
MAG myelin associated glycoprotein 0.108609
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.105094
DNTT DNA nucleotidylexotransferase 0.104576
MYOG myogenin (myogenic factor 4) 0.103832
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.099474
KRT8 keratin 8, type II 0.098678
SETD1A SET domain containing 1A 0.09794
FBXL20 F-box and leucine-rich repeat protein 20 0.097045
PLCG1 phospholipase C, gamma 1 0.096568
MUC2 mucin 2, oligomeric mucus/gel-forming 0.095064
KRT5 keratin 5, type II 0.093762
APOA1 apolipoprotein A-I 0.091385
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.091277
AMBP alpha-1-microglobulin/bikunin precursor 0.088156
KRT20 keratin 20, type I 0.086939
PLAT plasminogen activator, tissue 0.086199
BCL2 B-cell CLL/lymphoma 2 0.08591
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.083295
HIST2H2AC histone cluster 2, H2ac 0.083089
S100B S100 calcium binding protein B 0.083089
HIST2H2AA3 histone cluster 2, H2aa3 0.083059
HIST2H2AA4 histone cluster 2, H2aa4 0.083059
MUC1 mucin 1, cell surface associated 0.082674
F10 coagulation factor X 0.08053
RTN4R reticulon 4 receptor 0.0805
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 0.079748
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 0.079082
LPA lipoprotein, Lp(a) 0.078962
CS citrate synthase 0.07872
S100A6 S100 calcium binding protein A6 0.07872
AMACR alpha-methylacyl-CoA racemase 0.0775
GJA1 gap junction protein, alpha 1, 43kDa 0.077012
GAL galanin/GMAP prepropeptide 0.076827
HNF1B HNF1 homeobox B 0.076735
TNNT2 troponin T type 2 (cardiac) 0.076611
MPO myeloperoxidase 0.073454
TNF tumor necrosis factor 0.073048
LYZ lysozyme 0.072611
GPC3 glypican 3 0.071954
KITLG KIT ligand 0.07164
MKKS McKusick-Kaufman syndrome 0.071483
CLDN11 claudin 11 0.070572
THBS2 thrombospondin 2 0.070541
EPAS1 endothelial PAS domain protein 1 0.070131
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.069847