cardiac interstitial fibrosis Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process (Mammalian Phenotype Ontology, MP_0005608)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005608
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Genes

35 gene mutations causing the cardiac interstitial fibrosis phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACE2 angiotensin I converting enzyme 2
AGTR1 angiotensin II receptor, type 1
ASXL2 additional sex combs like transcriptional regulator 2
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BCL6 B-cell CLL/lymphoma 6
COX1
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein)
DES desmin
DNM1L dynamin 1-like
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
IGHMBP2 immunoglobulin mu binding protein 2
LAMA4 laminin, alpha 4
LMNA lamin A/C
MYBPC3 myosin binding protein C, cardiac
MYH10 myosin, heavy chain 10, non-muscle
MYH6 myosin, heavy chain 6, cardiac muscle, alpha
MYLK3 myosin light chain kinase 3
NEK6 NIMA-related kinase 6
NOX4 NADPH oxidase 4
NPR1 natriuretic peptide receptor 1
NPY1R neuropeptide Y receptor Y1
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SOS1 son of sevenless homolog 1 (Drosophila)
TLR2 toll-like receptor 2
TNNI3 troponin I type 3 (cardiac)
TNNT2 troponin T type 2 (cardiac)
TTN titin
WRN Werner syndrome, RecQ helicase-like
ZMPSTE24 zinc metallopeptidase STE24