cardiac hypertrophy Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description an increase in size of the cardiac tissue, not due to increased cell number (Mammalian Phenotype Ontology, MP_0001625)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001625
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Genes

142 gene mutations causing the cardiac hypertrophy phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACAN aggrecan
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6
ADIPOQ adiponectin, C1Q and collagen domain containing
ADM adrenomedullin
ADORA2A adenosine A2a receptor
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
ANK1 ankyrin 1, erythrocytic
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APOE apolipoprotein E
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BMP4 bone morphogenetic protein 4
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CASQ2 calsequestrin 2 (cardiac muscle)
CAV1 caveolin 1, caveolae protein, 22kDa
CAV3 caveolin 3
CD36 CD36 molecule (thrombospondin receptor)
CHGA chromogranin A
CHRD chordin
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric)
CNOT3 CCR4-NOT transcription complex, subunit 3
COL1A1 collagen, type I, alpha 1
CORIN corin, serine peptidase
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein)
CYBB cytochrome b-245, beta polypeptide
DES desmin
DNAH11 dynein, axonemal, heavy chain 11
DNAH5 dynein, axonemal, heavy chain 5
DYX1C1 dyslexia susceptibility 1 candidate 1
EGFR epidermal growth factor receptor
ELN elastin
ESR2 estrogen receptor 2 (ER beta)
FABP3 fatty acid binding protein 3, muscle and heart
FBN1 fibrillin 1
FHL2 four and a half LIM domains 2
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOXJ1 forkhead box J1
FXYD1 FXYD domain containing ion transport regulator 1
GAA glucosidase, alpha; acid
GJA1 gap junction protein, alpha 1, 43kDa
GLA galactosidase, alpha
GLTSCR1L GLTSCR1-like
GRK5 G protein-coupled receptor kinase 5
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY2C guanylate cyclase 2C
HBEGF heparin-binding EGF-like growth factor
HDAC5 histone deacetylase 5
HDAC9 histone deacetylase 9
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HMGA1 high mobility group AT-hook 1
HOPX HOP homeobox
HOXA1 homeobox A1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HRAS Harvey rat sarcoma viral oncogene homolog
HSPB8 heat shock 22kDa protein 8
IER3 immediate early response 3
INPP5F inositol polyphosphate-5-phosphatase F
INS insulin
IRX4 iroquois homeobox 4
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KLF15 Kruppel-like factor 15
KLF3 Kruppel-like factor 3 (basic)
KLF5 Kruppel-like factor 5 (intestinal)
LAMA4 laminin, alpha 4
LEP leptin
LEPR leptin receptor
LOX lysyl oxidase
LRP2 low density lipoprotein receptor-related protein 2
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
MB myoglobin
MORF4L1 mortality factor 4 like 1
MTUS1 microtubule associated tumor suppressor 1
MUS81 MUS81 structure-specific endonuclease subunit
MYBPC3 myosin binding protein C, cardiac
MYH10 myosin, heavy chain 10, non-muscle
MYH6 myosin, heavy chain 6, cardiac muscle, alpha
MYLK3 myosin light chain kinase 3
MYOZ2 myozenin 2
NCF1 neutrophil cytosolic factor 1
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NEK6 NIMA-related kinase 6
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NOS1 nitric oxide synthase 1 (neuronal)
NOS3 nitric oxide synthase 3 (endothelial cell)
NOX4 NADPH oxidase 4
NPPA natriuretic peptide A
NPR1 natriuretic peptide receptor 1
NTF3 neurotrophin 3
PDGFA platelet-derived growth factor alpha polypeptide
PFKM phosphofructokinase, muscle
PHC1 polyhomeotic homolog 1 (Drosophila)
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PNPLA2 patatin-like phospholipase domain containing 2
PPARG peroxisome proliferator-activated receptor gamma
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RNLS renalase, FAD-dependent amine oxidase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RYR2 ryanodine receptor 2 (cardiac)
SCNN1B sodium channel, non voltage gated 1 beta subunit
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SIRT1 sirtuin 1
SIRT7 sirtuin 7
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SLIT3 slit homolog 3 (Drosophila)
SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
SMTN smoothelin
SOD2 superoxide dismutase 2, mitochondrial
SOS1 son of sevenless homolog 1 (Drosophila)
SPTA1 spectrin, alpha, erythrocytic 1
SPTB spectrin, beta, erythrocytic
TAL1 T-cell acute lymphocytic leukemia 1
TCAP titin-cap
TERC telomerase RNA component
THBS4 thrombospondin 4
TIMP3 TIMP metallopeptidase inhibitor 3
TP53 tumor protein p53
TRIM54 tripartite motif containing 54
TRIM55 tripartite motif containing 55
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase
TTN titin
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFB vascular endothelial growth factor B
VIP vasoactive intestinal peptide
XIRP1 xin actin binding repeat containing 1
XIRP2 xin actin binding repeat containing 2