cardiac fibrosis Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description formation of fibrous tissue within the heart often resulting from inflammation or injury (Mammalian Phenotype Ontology, MP_0003141)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0003141
Similar Terms
Downloads & Tools

Genes

106 gene mutations causing the cardiac fibrosis phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5
ACADL acyl-CoA dehydrogenase, long chain
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
ACE2 angiotensin I converting enzyme 2
ACKR3 atypical chemokine receptor 3
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
AHR aryl hydrocarbon receptor
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ASXL2 additional sex combs like transcriptional regulator 2
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BCL6 B-cell CLL/lymphoma 6
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CAV3 caveolin 3
CHD2 chromodomain helicase DNA binding protein 2
CNOT3 CCR4-NOT transcription complex, subunit 3
COQ9 coenzyme Q9
COX1
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein)
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1
DES desmin
DMD dystrophin
DNM1L dynamin 1-like
DTNA dystrobrevin, alpha
EGR1 early growth response 1
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
F10 coagulation factor X
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FBN1 fibrillin 1
FHL2 four and a half LIM domains 2
FXN frataxin
GJA1 gap junction protein, alpha 1, 43kDa
GYS1 glycogen synthase 1 (muscle)
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
HBEGF heparin-binding EGF-like growth factor
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HMOX1 heme oxygenase 1
HOPX HOP homeobox
IGHMBP2 immunoglobulin mu binding protein 2
INPP5F inositol polyphosphate-5-phosphatase F
KLF5 Kruppel-like factor 5 (intestinal)
KRAS Kirsten rat sarcoma viral oncogene homolog
LAMA4 laminin, alpha 4
LDB3 LIM domain binding 3
LMNA lamin A/C
MAPK8 mitogen-activated protein kinase 8
MED30 mediator complex subunit 30
MIR22 microRNA 22
MMP9 matrix metallopeptidase 9
MYBPC3 myosin binding protein C, cardiac
MYH10 myosin, heavy chain 10, non-muscle
MYH6 myosin, heavy chain 6, cardiac muscle, alpha
MYL2 myosin, light chain 2, regulatory, cardiac, slow
MYLK3 myosin light chain kinase 3
NCKAP1L NCK-associated protein 1-like
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
NEK6 NIMA-related kinase 6
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NOX4 NADPH oxidase 4
NPPB natriuretic peptide B
NPR1 natriuretic peptide receptor 1
NPY1R neuropeptide Y receptor Y1
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PDCD1 programmed cell death 1
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDLIM3 PDZ and LIM domain 3
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PNPLA2 patatin-like phospholipase domain containing 2
PPARA peroxisome proliferator-activated receptor alpha
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBM20 RNA binding motif protein 20
RERE arginine-glutamic acid dipeptide (RE) repeats
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
RYR2 ryanodine receptor 2 (cardiac)
SCN5A sodium channel, voltage gated, type V alpha subunit
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SIRT7 sirtuin 7
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SOD2 superoxide dismutase 2, mitochondrial
SOS1 son of sevenless homolog 1 (Drosophila)
TCAP titin-cap
THBS4 thrombospondin 4
TIMP3 TIMP metallopeptidase inhibitor 3
TLR2 toll-like receptor 2
TNNI3 troponin I type 3 (cardiac)
TNNT2 troponin T type 2 (cardiac)
TREX1 three prime repair exonuclease 1
TTN titin
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WRN Werner syndrome, RecQ helicase-like
XIRP1 xin actin binding repeat containing 1
ZMPSTE24 zinc metallopeptidase STE24