carbenoxolone-4173 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the carbenoxolone-4173 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ACO2 aconitase 2, mitochondrial
ADAM8 ADAM metallopeptidase domain 8
AKAP7 A kinase (PRKA) anchor protein 7
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANG angiogenin, ribonuclease, RNase A family, 5
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
AQP6 aquaporin 6, kidney specific
ARMCX4 armadillo repeat containing, X-linked 4
ATN1 atrophin 1
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide
BIRC3 baculoviral IAP repeat containing 3
C11ORF16 chromosome 11 open reading frame 16
C14ORF1 chromosome 14 open reading frame 1
CA9 carbonic anhydrase IX
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CALB1 calbindin 1, 28kDa
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCDC33 coiled-coil domain containing 33
CD58 CD58 molecule
CFAP69 cilia and flagella associated protein 69
CLCN4 chloride channel, voltage-sensitive 4
CNKSR2 connector enhancer of kinase suppressor of Ras 2
COL8A1 collagen, type VIII, alpha 1
CPA2 carboxypeptidase A2 (pancreatic)
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CRHR1 corticotropin releasing hormone receptor 1
DBT dihydrolipoamide branched chain transacylase E2
DENND3 DENN/MADD domain containing 3
DGAT1 diacylglycerol O-acyltransferase 1
DOK4 docking protein 4
DVL2 dishevelled segment polarity protein 2
EPHB6 EPH receptor B6
FGF18 fibroblast growth factor 18
FGF2 fibroblast growth factor 2 (basic)
FST follistatin
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1
GPR15 G protein-coupled receptor 15
GRIP2 glutamate receptor interacting protein 2
GRM8 glutamate receptor, metabotropic 8
GYPB glycophorin B (MNS blood group)
HDAC6 histone deacetylase 6
HIST1H2BM histone cluster 1, H2bm
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
ICAM1 intercellular adhesion molecule 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGKV1D-13 immunoglobulin kappa variable 1D-13
IL7R interleukin 7 receptor
JAK3 Janus kinase 3
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KCNK10 potassium channel, two pore domain subfamily K, member 10
KIF1C kinesin family member 1C
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KLF1 Kruppel-like factor 1 (erythroid)
LAMB4 laminin, beta 4
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LOC100127972 uncharacterized LOC100127972
LPAR1 lysophosphatidic acid receptor 1
MAP1A microtubule-associated protein 1A
MGAT4C MGAT4 family, member C
MID1 midline 1
MIER2 mesoderm induction early response 1, family member 2
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OTOR otoraplin
PARP11 poly (ADP-ribose) polymerase family, member 11
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCDHGA9 protocadherin gamma subfamily A, 9
PDAP1 PDGFA associated protein 1
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2
PER1 period circadian clock 1
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PRB1 proline-rich protein BstNI subfamily 1
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
RASA3 RAS p21 protein activator 3
RBMS3 RNA binding motif, single stranded interacting protein 3
RIF1 replication timing regulatory factor 1
RUNX1 runt-related transcription factor 1
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SFRP4 secreted frizzled-related protein 4
SIPA1 signal-induced proliferation-associated 1
SLURP1 secreted LY6/PLAUR domain containing 1
SPRR2B small proline-rich protein 2B
TBCD tubulin folding cofactor D
TBR1 T-box, brain, 1
TCF3 transcription factor 3
TESPA1 thymocyte expressed, positive selection associated 1
TM4SF1 transmembrane 4 L six family member 1
TMEM176A transmembrane protein 176A
TRIM3 tripartite motif containing 3
TRPA1 transient receptor potential cation channel, subfamily A, member 1
USP29 ubiquitin specific peptidase 29
WDR55 WD repeat domain 55
WRNIP1 Werner helicase interacting protein 1
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
ZNF304 zinc finger protein 304
ZNF711 zinc finger protein 711

decreased expression

Symbol Name
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
ACADSB acyl-CoA dehydrogenase, short/branched chain
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADCK4 aarF domain containing kinase 4
AGMAT agmatine ureohydrolase (agmatinase)
ANKH ANKH inorganic pyrophosphate transport regulator
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ATG10 autophagy related 10
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C19ORF73 chromosome 19 open reading frame 73
C3AR1 complement component 3a receptor 1
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CAMK4 calcium/calmodulin-dependent protein kinase IV
CBX8 chromobox homolog 8
CD8A CD8a molecule
CDHR2 cadherin-related family member 2
CDK18 cyclin-dependent kinase 18
CDK6 cyclin-dependent kinase 6
CHM choroideremia (Rab escort protein 1)
CLCF1 cardiotrophin-like cytokine factor 1
CLGN calmegin
CPB2 carboxypeptidase B2 (plasma)
CTRL chymotrypsin-like
CUEDC1 CUE domain containing 1
CUL9 cullin 9
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DBF4B DBF4 zinc finger B
DCAF13 DDB1 and CUL4 associated factor 13
DCBLD2 discoidin, CUB and LCCL domain containing 2
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EPX eosinophil peroxidase
ERCC4 excision repair cross-complementation group 4
EXOC5 exocyst complex component 5
FAM110B family with sequence similarity 110, member B
FAM155A family with sequence similarity 155, member A
FBXO4 F-box protein 4
GMPR guanosine monophosphate reductase
GPR176 G protein-coupled receptor 176
HDAC11 histone deacetylase 11
HIST1H2AL histone cluster 1, H2al
HIST1H4F histone cluster 1, H4f
HOOK1 hook microtubule-tethering protein 1
HOXC4 homeobox C4
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
INO80D INO80 complex subunit D
IPO8 importin 8
KIAA1107 KIAA1107
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLRAP1 killer cell lectin-like receptor subfamily A pseudogene 1
KREMEN2 kringle containing transmembrane protein 2
LHX3 LIM homeobox 3
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LZTS3 leucine zipper, putative tumor suppressor family member 3
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
NPR3 natriuretic peptide receptor 3
OR2B6 olfactory receptor, family 2, subfamily B, member 6
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
OSGIN1 oxidative stress induced growth inhibitor 1
PAX9 paired box 9
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLCD1 phospholipase C, delta 1
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PLEKHO2 pleckstrin homology domain containing, family O member 2
PPARG peroxisome proliferator-activated receptor gamma
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RFPL3 ret finger protein-like 3
RHOBTB2 Rho-related BTB domain containing 2
RRAGB Ras-related GTP binding B
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SCN10A sodium channel, voltage gated, type X alpha subunit
SCN1B sodium channel, voltage gated, type I beta subunit
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SPINK5 serine peptidase inhibitor, Kazal type 5
STIM1 stromal interaction molecule 1
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYNC syncoilin, intermediate filament protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF2 trefoil factor 2
TMCC2 transmembrane and coiled-coil domain family 2
TRPM2 transient receptor potential cation channel, subfamily M, member 2
UCN urocortin
USB1 U6 snRNA biogenesis 1
VN1R1 vomeronasal 1 receptor 1
WDR78 WD repeat domain 78
ZBTB6 zinc finger and BTB domain containing 6
ZNF551 zinc finger protein 551