canonical wnt signaling pathway Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. (Gene Ontology, GO_0060070)
External Link http://amigo.geneontology.org/amigo/term/GO:0060070
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Genes

82 genes participating in the canonical wnt signaling pathway biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
APC adenomatous polyposis coli
AXIN1 axin 1
BCL9 B-cell CLL/lymphoma 9
BCL9L B-cell CLL/lymphoma 9-like
CCND1 cyclin D1
CDC42 cell division cycle 42
CDH3 cadherin 3, type 1, P-cadherin (placental)
CHD8 chromodomain helicase DNA binding protein 8
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DISC1 disrupted in schizophrenia 1
DVL1 dishevelled segment polarity protein 1
DVL2 dishevelled segment polarity protein 2
DVL3 dishevelled segment polarity protein 3
FGF8 fibroblast growth factor 8 (androgen-induced)
FZD1 frizzled class receptor 1
FZD10 frizzled class receptor 10
FZD2 frizzled class receptor 2
FZD3 frizzled class receptor 3
FZD4 frizzled class receptor 4
FZD5 frizzled class receptor 5
FZD7 frizzled class receptor 7
FZD8 frizzled class receptor 8
FZD9 frizzled class receptor 9
GATA3 GATA binding protein 3
GATA4 GATA binding protein 4
GSK3B glycogen synthase kinase 3 beta
HOXB9 homeobox B9
KDM6A lysine (K)-specific demethylase 6A
LEF1 lymphoid enhancer-binding factor 1
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LRP5 low density lipoprotein receptor-related protein 5
LRP5L low density lipoprotein receptor-related protein 5-like
LRP6 low density lipoprotein receptor-related protein 6
MED12 mediator complex subunit 12
MITF microphthalmia-associated transcription factor
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH6 myosin, heavy chain 6, cardiac muscle, alpha
NDP Norrie disease (pseudoglioma)
NKX2-5 NK2 homeobox 5
OTULIN OTU deubiquitinase with linear linkage specificity
PPAP2B phosphatidic acid phosphatase type 2B
PROP1 PROP paired-like homeobox 1
PSEN1 presenilin 1
PTEN phosphatase and tensin homolog
PTK7 protein tyrosine kinase 7 (inactive)
PTPRU protein tyrosine phosphatase, receptor type, U
PYGO2 pygopus family PHD finger 2
RARG retinoic acid receptor, gamma
RSPO1 R-spondin 1
RSPO3 R-spondin 3
RYR2 ryanodine receptor 2 (cardiac)
SDC1 syndecan 1
SFRP1 secreted frizzled-related protein 1
SHH sonic hedgehog
SMO smoothened, frizzled class receptor
SNAI2 snail family zinc finger 2
SOX17 SRY (sex determining region Y)-box 17
SOX4 SRY (sex determining region Y)-box 4
STK11 serine/threonine kinase 11
T T, brachyury homolog (mouse)
TBL1X transducin (beta)-like 1X-linked
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TDGF1 teratocarcinoma-derived growth factor 1
UBE2B ubiquitin-conjugating enzyme E2B
WNT1 wingless-type MMTV integration site family, member 1
WNT10B wingless-type MMTV integration site family, member 10B
WNT11 wingless-type MMTV integration site family, member 11
WNT2 wingless-type MMTV integration site family member 2
WNT2B wingless-type MMTV integration site family, member 2B
WNT3 wingless-type MMTV integration site family, member 3
WNT3A wingless-type MMTV integration site family, member 3A
WNT4 wingless-type MMTV integration site family, member 4
WNT5A wingless-type MMTV integration site family, member 5A
WNT7A wingless-type MMTV integration site family, member 7A
WNT7B wingless-type MMTV integration site family, member 7B
WNT8A wingless-type MMTV integration site family, member 8A
WNT9A wingless-type MMTV integration site family, member 9A
WNT9B wingless-type MMTV integration site family, member 9B
ZNRF3 zinc and ring finger 3