cancer Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis. (Human Disease Ontology, DOID_162)
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Genes

30 genes associated with the disease cancer in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACE angiotensin I converting enzyme
ARL11 ADP-ribosylation factor-like 11
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
CDKN2A cyclin-dependent kinase inhibitor 2A
CES1 carboxylesterase 1
CES2 carboxylesterase 2
CHEK2 checkpoint kinase 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DPYD dihydropyrimidine dehydrogenase
FANCC Fanconi anemia, complementation group C
GSTM1 glutathione S-transferase mu 1
HLA-B major histocompatibility complex, class I, B
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
MMP1 matrix metallopeptidase 1
NQO1 NAD(P)H dehydrogenase, quinone 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TGFBR1 transforming growth factor, beta receptor 1
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)