camptothecin-4541 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the camptothecin-4541 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2
ADAM23 ADAM metallopeptidase domain 23
ADM adrenomedullin
ATF3 activating transcription factor 3
BAMBI BMP and activin membrane-bound inhibitor
BEST2 bestrophin 2
BTBD18 BTB (POZ) domain containing 18
BTG2 BTG family, member 2
CBX4 chromobox homolog 4
CCDC71 coiled-coil domain containing 71
CD14 CD14 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COMMD4 COMM domain containing 4
CXCL2 chemokine (C-X-C motif) ligand 2
CXCR4 chemokine (C-X-C motif) receptor 4
DLX2 distal-less homeobox 2
DLX5 distal-less homeobox 5
EDN1 endothelin 1
EGR1 early growth response 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
FCF1 FCF1 rRNA-processing protein
FCMR Fc fragment of IgM receptor
FH fumarate hydratase
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXC1 forkhead box C1
FSTL3 follistatin-like 3 (secreted glycoprotein)
GADD45B growth arrest and DNA-damage-inducible, beta
GPR3 G protein-coupled receptor 3
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene)
H2AFJ H2A histone family, member J
HBEGF heparin-binding EGF-like growth factor
HEXIM1 hexamethylene bis-acetamide inducible 1
HIST1H2AM histone cluster 1, H2am
HIST1H2BG histone cluster 1, H2bg
HIST1H3B histone cluster 1, H3b
HIST1H4E histone cluster 1, H4e
HIST2H2BE histone cluster 2, H2be
HOXA1 homeobox A1
HOXB2 homeobox B2
HYAL1 hyaluronoglucosaminidase 1
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER5 immediate early response 5
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KIF1C kinesin family member 1C
KLF4 Kruppel-like factor 4 (gut)
LEFTY1 left-right determination factor 1
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MSX1 msh homeobox 1
NDOR1 NADPH dependent diflavin oxidoreductase 1
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGDN neuroguidin, EIF4E binding protein
NR4A2 nuclear receptor subfamily 4, group A, member 2
OSR2 odd-skipped related transciption factor 2
PABPN1 poly(A) binding protein, nuclear 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
RAB40A RAB40A, member RAS oncogene family
RASL11B RAS-like, family 11, member B
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RFPL3S RFPL3 antisense
RHOB ras homolog family member B
RND1 Rho family GTPase 1
RPS28 ribosomal protein S28
RRAD Ras-related associated with diabetes
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SGK1 serum/glucocorticoid regulated kinase 1
SIRT4 sirtuin 4
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SNAI1 snail family zinc finger 1
SNHG3 small nucleolar RNA host gene 3
SOCS1 suppressor of cytokine signaling 1
SRSF5 serine/arginine-rich splicing factor 5
TBCC tubulin folding cofactor C
TBL2 transducin (beta)-like 2
TCF3 transcription factor 3
TLDC1 TBC/LysM-associated domain containing 1
TLE4 transducin-like enhancer of split 4
TMEM177 transmembrane protein 177
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TPP1 tripeptidyl peptidase I
TSPYL2 TSPY-like 2
TUBB2A tubulin, beta 2A class IIa
UCN urocortin
ULBP2 UL16 binding protein 2
WNT16 wingless-type MMTV integration site family, member 16
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF362 zinc finger protein 362
ZNF500 zinc finger protein 500

decreased expression

Symbol Name
ADNP activity-dependent neuroprotector homeobox
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARID5B AT rich interactive domain 5B (MRF1-like)
ARSJ arylsulfatase family, member J
ASAP1-IT1 ASAP1 intronic transcript 1
BANP BTG3 associated nuclear protein
BCAR3 breast cancer anti-estrogen resistance 3
C5ORF30 chromosome 5 open reading frame 30
CASD1 CAS1 domain containing 1
CDCA4 cell division cycle associated 4
CHD1 chromodomain helicase DNA binding protein 1
CHRM3 cholinergic receptor, muscarinic 3
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CHSY1 chondroitin sulfate synthase 1
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CTCF CCCTC-binding factor (zinc finger protein)
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
DUSP5 dual specificity phosphatase 5
E2F6 E2F transcription factor 6
EFNA4 ephrin-A4
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
FAM60A family with sequence similarity 60, member A
FBXO34 F-box protein 34
GBX2 gastrulation brain homeobox 2
GLI3 GLI family zinc finger 3
GOLPH3 golgi phosphoprotein 3 (coat-protein)
GRAMD1B GRAM domain containing 1B
GUSBP3 glucuronidase, beta pseudogene 3
HJURP Holliday junction recognition protein
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1
ICE1 interactor of little elongation complex ELL subunit 1
IRS1 insulin receptor substrate 1
JMJD1C jumonji domain containing 1C
KAT7 K(lysine) acetyltransferase 7
KBTBD2 kelch repeat and BTB (POZ) domain containing 2
KIAA0232 KIAA0232
KIF18A kinesin family member 18A
KIN Kin17 DNA and RNA binding protein
LEMD3 LEM domain containing 3
LOC100272216 uncharacterized LOC100272216
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAPK6 mitogen-activated protein kinase 6
MKL2 MKL/myocardin-like 2
MTCL1 microtubule crosslinking factor 1
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit
NAV2 neuron navigator 2
NCOA6 nuclear receptor coactivator 6
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NFE2L2 nuclear factor, erythroid 2-like 2
NRIP1 nuclear receptor interacting protein 1
NUP153 nucleoporin 153kDa
OSBPL11 oxysterol binding protein-like 11
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIAS1 protein inhibitor of activated STAT, 1
PITPNB phosphatidylinositol transfer protein, beta
POLD3 polymerase (DNA-directed), delta 3, accessory subunit
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PUM2 pumilio RNA-binding family member 2
PVRL3 poliovirus receptor-related 3
QTRTD1 queuine tRNA-ribosyltransferase domain containing 1
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RCOR1 REST corepressor 1
REV1 REV1, polymerase (DNA directed)
RLF rearranged L-myc fusion
RNF111 ring finger protein 111
RSBN1 round spermatid basic protein 1
SAV1 salvador family WW domain containing protein 1
SCAF8 SR-related CTD-associated factor 8
SEC24B SEC24 family member B
SETD5 SET domain containing 5
SGMS1 sphingomyelin synthase 1
SLC38A2 solute carrier family 38, member 2
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
SUOX sulfite oxidase
SYBU syntabulin (syntaxin-interacting)
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TBC1D31 TBC1 domain family, member 31
TBCCD1 TBCC domain containing 1
TBPL1 TBP-like 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TRIM24 tripartite motif containing 24
TRIM32 tripartite motif containing 32
TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae)
UBE2O ubiquitin-conjugating enzyme E2O
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
VANGL1 VANGL planar cell polarity protein 1
VEGFC vascular endothelial growth factor C
WDR43 WD repeat domain 43
WDR47 WD repeat domain 47
XKR8 XK, Kell blood group complex subunit-related family, member 8
ZBED5 zinc finger, BED-type containing 5
ZC3H4 zinc finger CCCH-type containing 4
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF189 zinc finger protein 189
ZNF217 zinc finger protein 217
ZNF322P1 zinc finger protein 322 pseudogene 1
ZNF443 zinc finger protein 443