butirosin-666 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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200 genes differentially expressed following the butirosin-666 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADH6 alcohol dehydrogenase 6 (class V)
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
ATF6 activating transcription factor 6
AVPR1B arginine vasopressin receptor 1B
BIK BCL2-interacting killer (apoptosis-inducing)
BIN1 bridging integrator 1
BLMH bleomycin hydrolase
BMP7 bone morphogenetic protein 7
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
C11ORF80 chromosome 11 open reading frame 80
C17ORF70 chromosome 17 open reading frame 70
C17ORF80 chromosome 17 open reading frame 80
C1ORF116 chromosome 1 open reading frame 116
CA1 carbonic anhydrase I
CD82 CD82 molecule
CDC25A cell division cycle 25A
CDYL chromodomain protein, Y-like
CFAP70 cilia and flagella associated protein 70
CFD complement factor D (adipsin)
CXCR4 chemokine (C-X-C motif) receptor 4
CYTH1 cytohesin 1
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DRP2 dystrophin related protein 2
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EDC4 enhancer of mRNA decapping 4
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FUBP1 far upstream element (FUSE) binding protein 1
GBAP1 glucosidase, beta, acid pseudogene 1
GM2A GM2 ganglioside activator
GREB1L growth regulation by estrogen in breast cancer-like
GRK6 G protein-coupled receptor kinase 6
H2AFY2 H2A histone family, member Y2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIBCH 3-hydroxyisobutyryl-CoA hydrolase
HRH1 histamine receptor H1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
INO80B INO80 complex subunit B
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KLF15 Kruppel-like factor 15
KXD1 KxDL motif containing 1
LRRN2 leucine rich repeat neuronal 2
LZTS1 leucine zipper, putative tumor suppressor 1
LZTS3 leucine zipper, putative tumor suppressor family member 3
MARC1 mitochondrial amidoxime reducing component 1
MED1 mediator complex subunit 1
METTL3 methyltransferase like 3
MVK mevalonate kinase
MYL12B myosin, light chain 12B, regulatory
MYLIP myosin regulatory light chain interacting protein
MYO10 myosin X
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NSUN5P2 NOP2/Sun domain family, member 5 pseudogene 2
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
NUP210 nucleoporin 210kDa
PFAS phosphoribosylformylglycinamidine synthase
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLIN2 perilipin 2
PLSCR3 phospholipid scramblase 3
PRR14 proline rich 14
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RGS3 regulator of G-protein signaling 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF141 ring finger protein 141
SESN1 sestrin 1
SETDB1 SET domain, bifurcated 1
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SPN sialophorin
SPRR1A small proline-rich protein 1A
SPTB spectrin, beta, erythrocytic
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SREBF1 sterol regulatory element binding transcription factor 1
TCF3 transcription factor 3
THADA thyroid adenoma associated
TMEM184B transmembrane protein 184B
TMEM97 transmembrane protein 97
TSKU tsukushi, small leucine rich proteoglycan
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
TTC38 tetratricopeptide repeat domain 38
TXNRD2 thioredoxin reductase 2
USP19 ubiquitin specific peptidase 19
WDR18 WD repeat domain 18
WDR61 WD repeat domain 61
WNK1 WNK lysine deficient protein kinase 1
ZNF329 zinc finger protein 329
ZNF783 zinc finger family member 783
ZSCAN32 zinc finger and SCAN domain containing 32

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADAP2 ArfGAP with dual PH domains 2
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ANXA2P3 annexin A2 pseudogene 3
AP4M1 adaptor-related protein complex 4, mu 1 subunit
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ASB6 ankyrin repeat and SOCS box containing 6
ATXN2 ataxin 2
BATF3 basic leucine zipper transcription factor, ATF-like 3
BIRC7 baculoviral IAP repeat containing 7
CA7 carbonic anhydrase VII
CBX4 chromobox homolog 4
CCDC130 coiled-coil domain containing 130
CCDC176 coiled-coil domain containing 176
CDK18 cyclin-dependent kinase 18
CDK3 cyclin-dependent kinase 3
CEP72 centrosomal protein 72kDa
CIC capicua transcriptional repressor
CIDEB cell death-inducing DFFA-like effector b
CLCN5 chloride channel, voltage-sensitive 5
CNTD2 cyclin N-terminal domain containing 2
CTAGE9 CTAGE family, member 9
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTSE cathepsin E
DAAM2 dishevelled associated activator of morphogenesis 2
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DMBT1 deleted in malignant brain tumors 1
EDAR ectodysplasin A receptor
EFNA3 ephrin-A3
ELP6 elongator acetyltransferase complex subunit 6
EPCAM epithelial cell adhesion molecule
FAM188A family with sequence similarity 188, member A
FGD6 FYVE, RhoGEF and PH domain containing 6
FTCD formimidoyltransferase cyclodeaminase
FUZ fuzzy planar cell polarity protein
GDF9 growth differentiation factor 9
GJB1 gap junction protein, beta 1, 32kDa
GPR27 G protein-coupled receptor 27
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
HAND1 heart and neural crest derivatives expressed 1
HHIPL2 HHIP-like 2
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HMHA1 histocompatibility (minor) HA-1
INHBC inhibin, beta C
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
JUNB jun B proto-oncogene
KLF7 Kruppel-like factor 7 (ubiquitous)
KLHL25 kelch-like family member 25
KLHL3 kelch-like family member 3
KLK8 kallikrein-related peptidase 8
KRT6A keratin 6A, type II
LRRC15 leucine rich repeat containing 15
LRRC48 leucine rich repeat containing 48
LRRC8E leucine rich repeat containing 8 family, member E
LUZP4 leucine zipper protein 4
LY86 lymphocyte antigen 86
MAPKBP1 mitogen-activated protein kinase binding protein 1
MBD5 methyl-CpG binding domain protein 5
MED23 mediator complex subunit 23
MFGE8 milk fat globule-EGF factor 8 protein
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MYLK myosin light chain kinase
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit
NIP7 NIP7, nucleolar pre-rRNA processing protein
PC pyruvate carboxylase
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PER3 period circadian clock 3
PGC progastricsin (pepsinogen C)
PMEL premelanosome protein
PMM2 phosphomannomutase 2
POLM polymerase (DNA directed), mu
POM121L2 POM121 transmembrane nucleoporin-like 2
PRMT3 protein arginine methyltransferase 3
PTPRE protein tyrosine phosphatase, receptor type, E
SASH3 SAM and SH3 domain containing 3
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SHROOM2 shroom family member 2
SLC35F6 solute carrier family 35, member F6
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13
SMYD5 SMYD family member 5
SPON2 spondin 2, extracellular matrix protein
STAG3L1 stromal antigen 3-like 1 (pseudogene)
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TGFBR1 transforming growth factor, beta receptor 1
TMPRSS6 transmembrane protease, serine 6
TRAPPC2 trafficking protein particle complex 2
TTC23 tetratricopeptide repeat domain 23
TULP4 tubby like protein 4
TXLNG taxilin gamma
UGDH UDP-glucose 6-dehydrogenase
UTP14C UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
VWA1 von Willebrand factor A domain containing 1
ZNF432 zinc finger protein 432
ZSCAN26 zinc finger and SCAN domain containing 26