butacaine-6225 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the butacaine-6225 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSM5 acyl-CoA synthetase medium-chain family member 5
ADAM23 ADAM metallopeptidase domain 23
ADGRE5 adhesion G protein-coupled receptor E5
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
AKR1C1 aldo-keto reductase family 1, member C1
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ASTN2 astrotactin 2
ATAD5 ATPase family, AAA domain containing 5
ATP7A ATPase, Cu++ transporting, alpha polypeptide
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
C21ORF2 chromosome 21 open reading frame 2
CCRL2 chemokine (C-C motif) receptor-like 2
CDC25A cell division cycle 25A
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CIR1 corepressor interacting with RBPJ, 1
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CREBZF CREB/ATF bZIP transcription factor
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DGCR8 DGCR8 microprocessor complex subunit
DIO2 deiodinase, iodothyronine, type II
DSCAM Down syndrome cell adhesion molecule
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EPHA2 EPH receptor A2
F3 coagulation factor III (thromboplastin, tissue factor)
GATA4 GATA binding protein 4
GMPR guanosine monophosphate reductase
GPR153 G protein-coupled receptor 153
GPR176 G protein-coupled receptor 176
GSTA3 glutathione S-transferase alpha 3
HIST1H2AJ histone cluster 1, H2aj
HNF1B HNF1 homeobox B
HOMER3 homer scaffolding protein 3
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFNA14 interferon, alpha 14
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT19P2 keratin 19 pseudogene 2
LAT2 linker for activation of T cells family, member 2
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LRRC41 leucine rich repeat containing 41
LUZP1 leucine zipper protein 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGOH2P mago-nashi homolog 2, pseudogene
MAL mal, T-cell differentiation protein
MED14 mediator complex subunit 14
MINK1 misshapen-like kinase 1
MPPE1 metallophosphoesterase 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NKAIN1 Na+/K+ transporting ATPase interacting 1
NPTX1 neuronal pentraxin I
NRGN neurogranin (protein kinase C substrate, RC3)
OGFR opioid growth factor receptor
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDE4DIP phosphodiesterase 4D interacting protein
PGP phosphoglycolate phosphatase
PHC3 polyhomeotic homolog 3 (Drosophila)
PLCH1 phospholipase C, eta 1
POLL polymerase (DNA directed), lambda
PPIA peptidylprolyl isomerase A (cyclophilin A)
PRDX2 peroxiredoxin 2
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PYCRL pyrroline-5-carboxylate reductase-like
RAB11FIP3 RAB11 family interacting protein 3 (class II)
RARG retinoic acid receptor, gamma
RGS10 regulator of G-protein signaling 10
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RPS3A ribosomal protein S3A
RUFY3 RUN and FYVE domain containing 3
SCG2 secretogranin II
SERHL2 serine hydrolase-like 2
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SP100 SP100 nuclear antigen
SPAG8 sperm associated antigen 8
ST20 suppressor of tumorigenicity 20
STYK1 serine/threonine/tyrosine kinase 1
SUGP1 SURP and G patch domain containing 1
SUPT7L suppressor of Ty 7 (S. cerevisiae)-like
SYNGR1 synaptogyrin 1
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TICAM1 toll-like receptor adaptor molecule 1
TMEM63A transmembrane protein 63A
TUBGCP5 tubulin, gamma complex associated protein 5
UBE3A ubiquitin protein ligase E3A
UBXN1 UBX domain protein 1
ULBP2 UL16 binding protein 2
VARS valyl-tRNA synthetase
VIPR2 vasoactive intestinal peptide receptor 2
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
WDR1 WD repeat domain 1
WIPI2 WD repeat domain, phosphoinositide interacting 2
ZBED4 zinc finger, BED-type containing 4
ZER1 zyg-11 related, cell cycle regulator
ZNF224 zinc finger protein 224
ZNF446 zinc finger protein 446
ZSCAN32 zinc finger and SCAN domain containing 32

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
AES amino-terminal enhancer of split
AKR1C3 aldo-keto reductase family 1, member C3
AKTIP AKT interacting protein
ATG2B autophagy related 2B
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BTF3P11 basic transcription factor 3 pseudogene 11
C10ORF88 chromosome 10 open reading frame 88
C11ORF95 chromosome 11 open reading frame 95
C12ORF4 chromosome 12 open reading frame 4
C22ORF29 chromosome 22 open reading frame 29
C4ORF29 chromosome 4 open reading frame 29
CAMTA2 calmodulin binding transcription activator 2
CASP3 caspase 3, apoptosis-related cysteine peptidase
CBX4 chromobox homolog 4
CBX7 chromobox homolog 7
CCDC85C coiled-coil domain containing 85C
CCNJ cyclin J
CFD complement factor D (adipsin)
CLSTN1 calsyntenin 1
COPS7B COP9 signalosome subunit 7B
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DEAF1 DEAF1 transcription factor
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DOCK1 dedicator of cytokinesis 1
EAF2 ELL associated factor 2
EIF5A2 eukaryotic translation initiation factor 5A2
EPB41L5 erythrocyte membrane protein band 4.1 like 5
EXOC2 exocyst complex component 2
FAM53B family with sequence similarity 53, member B
FKBP10 FK506 binding protein 10, 65 kDa
FPGS folylpolyglutamate synthase
GLI3 GLI family zinc finger 3
GMEB1 glucocorticoid modulatory element binding protein 1
GPATCH2 G patch domain containing 2
HIRIP3 HIRA interacting protein 3
HIST1H2AM histone cluster 1, H2am
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
IFT81 intraflagellar transport 81
JUNB jun B proto-oncogene
KDM5C lysine (K)-specific demethylase 5C
KIAA0894 KIAA0894 protein
KIF3B kinesin family member 3B
KIFC1 kinesin family member C1
LEMD3 LEM domain containing 3
LMNB1 lamin B1
LRP5L low density lipoprotein receptor-related protein 5-like
MAPK12 mitogen-activated protein kinase 12
MED15 mediator complex subunit 15
MFSD12 major facilitator superfamily domain containing 12
MNS1 meiosis-specific nuclear structural 1
MOCS3 molybdenum cofactor synthesis 3
MRPL2 mitochondrial ribosomal protein L2
MXI1 MAX interactor 1, dimerization protein
MYBBP1A MYB binding protein (P160) 1a
NCAM2 neural cell adhesion molecule 2
OCEL1 occludin/ELL domain containing 1
OLFML3 olfactomedin-like 3
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLD3 phospholipase D family, member 3
PTDSS2 phosphatidylserine synthase 2
RAD54L2 RAD54-like 2 (S. cerevisiae)
RBM23 RNA binding motif protein 23
RNF126P1 ring finger protein 126 pseudogene 1
SCAMP5 secretory carrier membrane protein 5
SCML1 sex comb on midleg-like 1 (Drosophila)
SCML2 sex comb on midleg-like 2 (Drosophila)
SECISBP2 SECIS binding protein 2
SETD8 SET domain containing (lysine methyltransferase) 8
SH2D4A SH2 domain containing 4A
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC46A3 solute carrier family 46, member 3
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SNORA21 small nucleolar RNA, H/ACA box 21
SSFA2 sperm specific antigen 2
STAG3L4 stromal antigen 3-like 4 (pseudogene)
THOP1 thimet oligopeptidase 1
TMEM134 transmembrane protein 134
TMEM177 transmembrane protein 177
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TPST2 tyrosylprotein sulfotransferase 2
TRAIP TRAF interacting protein
TRIM45 tripartite motif containing 45
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TUBA3C tubulin, alpha 3c
UBXN6 UBX domain protein 6
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
USP18 ubiquitin specific peptidase 18
USP36 ubiquitin specific peptidase 36
ZNF254 zinc finger protein 254
ZNF276 zinc finger protein 276
ZNF408 zinc finger protein 408
ZNF623 zinc finger protein 623
ZNF675 zinc finger protein 675
ZSCAN5A zinc finger and SCAN domain containing 5A