bupropion-6256 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the bupropion-6256 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATP9A ATPase, class II, type 9A
BMP5 bone morphogenetic protein 5
BST2 bone marrow stromal cell antigen 2
CA5B carbonic anhydrase VB, mitochondrial
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD58 CD58 molecule
CFHR2 complement factor H-related 2
CFLAR CASP8 and FADD-like apoptosis regulator
CHMP6 charged multivesicular body protein 6
CLPS colipase, pancreatic
CLSTN3 calsyntenin 3
COL5A1 collagen, type V, alpha 1
CRYBB2P1 crystallin, beta B2 pseudogene 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DIAPH1 diaphanous-related formin 1
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ELK1 ELK1, member of ETS oncogene family
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPS8L1 EPS8-like 1
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
EVA1B eva-1 homolog B (C. elegans)
EVI5 ecotropic viral integration site 5
EXO5 exonuclease 5
FAIM2 Fas apoptotic inhibitory molecule 2
FAM134B family with sequence similarity 134, member B
FBXO31 F-box protein 31
FER fer (fps/fes related) tyrosine kinase
FNDC3A fibronectin type III domain containing 3A
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPC3 glypican 3
GRIK5 glutamate receptor, ionotropic, kainate 5
GSTCD glutathione S-transferase, C-terminal domain containing
GYG2 glycogenin 2
HIC2 hypermethylated in cancer 2
HOXC10 homeobox C10
HOXC11 homeobox C11
ICAM1 intercellular adhesion molecule 1
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
INO80D INO80 complex subunit D
IQSEC2 IQ motif and Sec7 domain 2
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLHL28 kelch-like family member 28
KLK5 kallikrein-related peptidase 5
KRT6B keratin 6B, type II
LOC284244 uncharacterized LOC284244
LPIN2 lipin 2
LRRC23 leucine rich repeat containing 23
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAP4 microtubule-associated protein 4
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MMRN2 multimerin 2
MXD4 MAX dimerization protein 4
MYOF myoferlin
NPFFR1 neuropeptide FF receptor 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
ONECUT1 one cut homeobox 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCLO piccolo presynaptic cytomatrix protein
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDGFA platelet-derived growth factor alpha polypeptide
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PKLR pyruvate kinase, liver and RBC
PLCD1 phospholipase C, delta 1
PLK4 polo-like kinase 4
PLSCR3 phospholipid scramblase 3
POLR2J4 polymerase (RNA) II (DNA directed) polypeptide J4, pseudogene
PTCH2 patched 2
QKI QKI, KH domain containing, RNA binding
RAB6B RAB6B, member RAS oncogene family
REST RE1-silencing transcription factor
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
SFTPA2 surfactant protein A2
SH3BP2 SH3-domain binding protein 2
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SP110 SP110 nuclear body protein
SPPL2B signal peptide peptidase like 2B
STAB2 stabilin 2
STK3 serine/threonine kinase 3
SUGP1 SURP and G patch domain containing 1
SUN1 Sad1 and UNC84 domain containing 1
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
UBE3A ubiquitin protein ligase E3A
UEVLD UEV and lactate/malate dehyrogenase domains
VAMP4 vesicle-associated membrane protein 4
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WDR62 WD repeat domain 62
ZBTB48 zinc finger and BTB domain containing 48
ZER1 zyg-11 related, cell cycle regulator
ZNF771 zinc finger protein 771

decreased expression

Symbol Name
AEN apoptosis enhancing nuclease
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKTIP AKT interacting protein
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANXA2P3 annexin A2 pseudogene 3
AXIN1 axin 1
BAX BCL2-associated X protein
BBS7 Bardet-Biedl syndrome 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDR2L cerebellar degeneration-related protein 2-like
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CLCN5 chloride channel, voltage-sensitive 5
CNKSR1 connector enhancer of kinase suppressor of Ras 1
COBL cordon-bleu WH2 repeat protein
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
DDIT3 DNA-damage-inducible transcript 3
DVL1 dishevelled segment polarity protein 1
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
EIF5A2 eukaryotic translation initiation factor 5A2
EPPK1 epiplakin 1
FGGY FGGY carbohydrate kinase domain containing
FIP1L1 factor interacting with PAPOLA and CPSF1
FLT4 fms-related tyrosine kinase 4
FOSL1 FOS-like antigen 1
FYCO1 FYVE and coiled-coil domain containing 1
GADD45G growth arrest and DNA-damage-inducible, gamma
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B
GLB1L2 galactosidase, beta 1-like 2
GLS2 glutaminase 2 (liver, mitochondrial)
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
GUSBP3 glucuronidase, beta pseudogene 3
HINFP histone H4 transcription factor
HIRA histone cell cycle regulator
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HMHA1 histocompatibility (minor) HA-1
HOXA5 homeobox A5
IL12RB1 interleukin 12 receptor, beta 1
IL15RA interleukin 15 receptor, alpha
IMPACT impact RWD domain protein
IPO13 importin 13
IRF6 interferon regulatory factor 6
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
LRRC8E leucine rich repeat containing 8 family, member E
MBTD1 mbt domain containing 1
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
METTL21B methyltransferase like 21B
MFSD12 major facilitator superfamily domain containing 12
MNX1 motor neuron and pancreas homeobox 1
MTCL1 microtubule crosslinking factor 1
MTHFSD methenyltetrahydrofolate synthetase domain containing
NDE1 nudE neurodevelopment protein 1
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OSMR oncostatin M receptor
PARG poly (ADP-ribose) glycohydrolase
PCNXL4 pecanex-like 4 (Drosophila)
PGBD5 piggyBac transposable element derived 5
PILRB paired immunoglobin-like type 2 receptor beta
POMT2 protein-O-mannosyltransferase 2
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
PTCD2 pentatricopeptide repeat domain 2
RAB5B RAB5B, member RAS oncogene family
RANBP17 RAN binding protein 17
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RBL1 retinoblastoma-like 1
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
RGS17 regulator of G-protein signaling 17
RPAIN RPA interacting protein
RPAP1 RNA polymerase II associated protein 1
RPL23AP7 ribosomal protein L23a pseudogene 7
SCGB2A2 secretoglobin, family 2A, member 2
SECTM1 secreted and transmembrane 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC25A40 solute carrier family 25, member 40
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SPATA7 spermatogenesis associated 7
STBD1 starch binding domain 1
SYCP2 synaptonemal complex protein 2
TAGLN transgelin
TMEM2 transmembrane protein 2
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
UBQLN4 ubiquilin 4
UBXN2B UBX domain protein 2B
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
ULBP2 UL16 binding protein 2
WLS wntless Wnt ligand secretion mediator
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZNF219 zinc finger protein 219
ZNF430 zinc finger protein 430
ZNF586 zinc finger protein 586
ZNF672 zinc finger protein 672
ZNF74 zinc finger protein 74
ZNF768 zinc finger protein 768
ZNF787 zinc finger protein 787
ZNF813 zinc finger protein 813