bupivacaine-2404 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the bupivacaine-2404 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AGRN agrin
AKAP8L A kinase (PRKA) anchor protein 8-like
ALOX5 arachidonate 5-lipoxygenase
ARID4B AT rich interactive domain 4B (RBP1-like)
ARRB1 arrestin, beta 1
BMP8A bone morphogenetic protein 8a
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BTD biotinidase
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1RL complement component 1, r subcomponent-like
CASS4 Cas scaffolding protein family member 4
CD300C CD300c molecule
CD79B CD79b molecule, immunoglobulin-associated beta
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDKL3 cyclin-dependent kinase-like 3
CDO1 cysteine dioxygenase type 1
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
CHPF chondroitin polymerizing factor
CNGB3 cyclic nucleotide gated channel beta 3
COL14A1 collagen, type XIV, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CRHR2 corticotropin releasing hormone receptor 2
CRIP1 cysteine-rich protein 1 (intestinal)
CRMP1 collapsin response mediator protein 1
DLGAP1 discs, large (Drosophila) homolog-associated protein 1
DSC3 desmocollin 3
DTNA dystrobrevin, alpha
EIF1 eukaryotic translation initiation factor 1
EYA3 EYA transcriptional coactivator and phosphatase 3
FAM127B family with sequence similarity 127, member B
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FCMR Fc fragment of IgM receptor
FGD6 FYVE, RhoGEF and PH domain containing 6
FGF22 fibroblast growth factor 22
FXYD2 FXYD domain containing ion transport regulator 2
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GAN gigaxonin
GFER growth factor, augmenter of liver regeneration
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GMPR guanosine monophosphate reductase
GRM1 glutamate receptor, metabotropic 1
GSTTP1 glutathione S-transferase theta pseudogene 1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOXA9 homeobox A9
ICMT isoprenylcysteine carboxyl methyltransferase
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma
IL27RA interleukin 27 receptor, alpha
ITIH1 inter-alpha-trypsin inhibitor heavy chain 1
JAKMIP2 janus kinase and microtubule interacting protein 2
KCNK1 potassium channel, two pore domain subfamily K, member 1
LAMP1 lysosomal-associated membrane protein 1
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
LINC00597 long intergenic non-protein coding RNA 597
MICALL1 MICAL-like 1
NEBL nebulette
NLGN1 neuroligin 1
OLFML2A olfactomedin-like 2A
OVGP1 oviductal glycoprotein 1, 120kDa
PCIF1 PDX1 C-terminal inhibiting factor 1
PDLIM2 PDZ and LIM domain 2 (mystique)
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PLK4 polo-like kinase 4
PLSCR4 phospholipid scramblase 4
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PRSS23 protease, serine, 23
RAB40AL RAB40A, member RAS oncogene family-like
RAP1GAP2 RAP1 GTPase activating protein 2
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RUNX1 runt-related transcription factor 1
RXRB retinoid X receptor, beta
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SIPA1L3 signal-induced proliferation-associated 1 like 3
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2
SLC35F6 solute carrier family 35, member F6
SLC5A12 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SP1 Sp1 transcription factor
SPX spexin hormone
SS18 synovial sarcoma translocation, chromosome 18
STBD1 starch binding domain 1
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TAPBP TAP binding protein (tapasin)
TFDP3 transcription factor Dp family, member 3
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRA T cell receptor alpha locus
TRAF4 TNF receptor-associated factor 4
TSC22D4 TSC22 domain family, member 4
U2AF2 U2 small nuclear RNA auxiliary factor 2
VCX2 variable charge, X-linked 2
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
ADAM23 ADAM metallopeptidase domain 23
ADGRE2 adhesion G protein-coupled receptor E2
ANAPC2 anaphase promoting complex subunit 2
ANXA2P2 annexin A2 pseudogene 2
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BOLA1 bolA family member 1
C11ORF68 chromosome 11 open reading frame 68
C16ORF59 chromosome 16 open reading frame 59
C1ORF159 chromosome 1 open reading frame 159
C1ORF95 chromosome 1 open reading frame 95
CA5BP1 carbonic anhydrase VB pseudogene 1
CAMKMT calmodulin-lysine N-methyltransferase
CAPN1 calpain 1, (mu/I) large subunit
CAPN15 calpain 15
CCDC85C coiled-coil domain containing 85C
CD34 CD34 molecule
CHMP6 charged multivesicular body protein 6
CISH cytokine inducible SH2-containing protein
CNPY4 canopy FGF signaling regulator 4
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DHRS3 dehydrogenase/reductase (SDR family) member 3
EDC4 enhancer of mRNA decapping 4
EMILIN2 elastin microfibril interfacer 2
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM184A family with sequence similarity 184, member A
FCHO1 FCH domain only 1
FGL1 fibrinogen-like 1
GAMT guanidinoacetate N-methyltransferase
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GTF2IRD1 GTF2I repeat domain containing 1
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HAMP hepcidin antimicrobial peptide
HIST1H2BE histone cluster 1, H2be
HOPX HOP homeobox
IFITM3 interferon induced transmembrane protein 3
IFT81 intraflagellar transport 81
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL18 interleukin 18
IL4R interleukin 4 receptor
IRAK4 interleukin-1 receptor-associated kinase 4
KIAA0753 KIAA0753
LRP5 low density lipoprotein receptor-related protein 5
LSP1 lymphocyte-specific protein 1
LTBP2 latent transforming growth factor beta binding protein 2
MCTP2 multiple C2 domains, transmembrane 2
MEGF8 multiple EGF-like-domains 8
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MLPH melanophilin
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NBEAL2 neurobeachin-like 2
NIPAL2 NIPA-like domain containing 2
NR1H2 nuclear receptor subfamily 1, group H, member 2
NRBP1 nuclear receptor binding protein 1
NT5M 5',3'-nucleotidase, mitochondrial
OCEL1 occludin/ELL domain containing 1
OTUD3 OTU deubiquitinase 3
PADI1 peptidyl arginine deiminase, type I
PEX26 peroxisomal biogenesis factor 26
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
POLM polymerase (DNA directed), mu
PPARG peroxisome proliferator-activated receptor gamma
PRKG2 protein kinase, cGMP-dependent, type II
RAB33B RAB33B, member RAS oncogene family
RAB3A RAB3A, member RAS oncogene family
RFPL1S RFPL1 antisense RNA 1
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNASE3 ribonuclease, RNase A family, 3
RNF121 ring finger protein 121
RNF122 ring finger protein 122
RPAP1 RNA polymerase II associated protein 1
SETD8 SET domain containing (lysine methyltransferase) 8
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SMA4 glucuronidase, beta pseudogene
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SPATA2L spermatogenesis associated 2-like
SPON2 spondin 2, extracellular matrix protein
SPP1 secreted phosphoprotein 1
TEC tec protein tyrosine kinase
THRAP3 thyroid hormone receptor associated protein 3
TM7SF2 transmembrane 7 superfamily member 2
TMEM8A transmembrane protein 8A
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNRC6B trinucleotide repeat containing 6B
TUBA3C tubulin, alpha 3c
USP27X ubiquitin specific peptidase 27, X-linked
WDR19 WD repeat domain 19
ZNF428 zinc finger protein 428
ZNF701 zinc finger protein 701
ZNF747 zinc finger protein 747
ZNF862 zinc finger protein 862