bumetanide-7440 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the bumetanide-7440 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ABCD4 ATP-binding cassette, sub-family D (ALD), member 4
ADK adenosine kinase
ADRBK1 adrenergic, beta, receptor kinase 1
AKR1C2 aldo-keto reductase family 1, member C2
AKT2 v-akt murine thymoma viral oncogene homolog 2
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit
ARNT aryl hydrocarbon receptor nuclear translocator
ASPH aspartate beta-hydroxylase
AZI2 5-azacytidine induced 2
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BBS9 Bardet-Biedl syndrome 9
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BLZF1 basic leucine zipper nuclear factor 1
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CAMK1 calcium/calmodulin-dependent protein kinase I
CBX7 chromobox homolog 7
CD44 CD44 molecule (Indian blood group)
CD58 CD58 molecule
CDC14A cell division cycle 14A
CDC40 cell division cycle 40
CEP104 centrosomal protein 104kDa
CEP290 centrosomal protein 290kDa
CLCN2 chloride channel, voltage-sensitive 2
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
CUL2 cullin 2
DST dystonin
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
ETV6 ets variant 6
F5 coagulation factor V (proaccelerin, labile factor)
FAM65A family with sequence similarity 65, member A
FGFR1 fibroblast growth factor receptor 1
FLOT1 flotillin 1
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
GAR1 GAR1 ribonucleoprotein
GBAS glioblastoma amplified sequence
GPR137 G protein-coupled receptor 137
H2AFX H2A histone family, member X
HEXA hexosaminidase A (alpha polypeptide)
HIPK3 homeodomain interacting protein kinase 3
HIST1H2BD histone cluster 1, H2bd
HIST1H4C histone cluster 1, H4c
HOXA4 homeobox A4
HSDL2 hydroxysteroid dehydrogenase like 2
HSPA13 heat shock protein 70kDa family, member 13
IRF2BP1 interferon regulatory factor 2 binding protein 1
KATNB1 katanin p80 (WD repeat containing) subunit B 1
KIFAP3 kinesin-associated protein 3
KLF6 Kruppel-like factor 6
LOC730101 uncharacterized LOC730101
MAST3 microtubule associated serine/threonine kinase 3
MIS18BP1 MIS18 binding protein 1
MPDZ multiple PDZ domain protein
MRPS11 mitochondrial ribosomal protein S11
MTMR2 myotubularin related protein 2
MVB12B multivesicular body subunit 12B
NAAA N-acylethanolamine acid amidase
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NIPAL2 NIPA-like domain containing 2
PCM1 pericentriolar material 1
PELI1 pellino E3 ubiquitin protein ligase 1
PHF3 PHD finger protein 3
PLAGL1 pleiomorphic adenoma gene-like 1
PROS1 protein S (alpha)
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RANBP3 RAN binding protein 3
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2
RNGTT RNA guanylyltransferase and 5'-phosphatase
RPS2 ribosomal protein S2
RUFY3 RUN and FYVE domain containing 3
SETD4 SET domain containing 4
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SMIM7 small integral membrane protein 7
SPTBN1 spectrin, beta, non-erythrocytic 1
STK17B serine/threonine kinase 17b
STX7 syntaxin 7
SYBU syntabulin (syntaxin-interacting)
TADA2A transcriptional adaptor 2A
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TMCO3 transmembrane and coiled-coil domains 3
TOP3A topoisomerase (DNA) III alpha
TPD52 tumor protein D52
TRIM2 tripartite motif containing 2
TRIM3 tripartite motif containing 3
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WDR59 WD repeat domain 59
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
YIPF2 Yip1 domain family, member 2
YIPF4 Yip1 domain family, member 4
YTHDC2 YTH domain containing 2
ZBTB1 zinc finger and BTB domain containing 1
ZNF141 zinc finger protein 141
ZNF573 zinc finger protein 573
ZNF609 zinc finger protein 609

decreased expression

Symbol Name
ABHD14A abhydrolase domain containing 14A
ABLIM3 actin binding LIM protein family, member 3
ACTG2 actin, gamma 2, smooth muscle, enteric
ANP32A-IT1 ANP32A intronic transcript 1
APOO apolipoprotein O
ARHGAP10 Rho GTPase activating protein 10
ATAD5 ATPase family, AAA domain containing 5
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
AXIN1 axin 1
BAGE B melanoma antigen
BBC3 BCL2 binding component 3
BIRC7 baculoviral IAP repeat containing 7
BMP4 bone morphogenetic protein 4
C17ORF70 chromosome 17 open reading frame 70
C2ORF27A chromosome 2 open reading frame 27A
C7ORF43 chromosome 7 open reading frame 43
CAMTA2 calmodulin binding transcription activator 2
CCDC186 coiled-coil domain containing 186
CCDC64 coiled-coil domain containing 64
CCDC85C coiled-coil domain containing 85C
CCNO cyclin O
CD82 CD82 molecule
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DSCAM Down syndrome cell adhesion molecule
ECHDC2 enoyl CoA hydratase domain containing 2
EDAR ectodysplasin A receptor
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM131A family with sequence similarity 131, member A
FANCE Fanconi anemia, complementation group E
FURIN furin (paired basic amino acid cleaving enzyme)
GLB1L2 galactosidase, beta 1-like 2
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GRB7 growth factor receptor-bound protein 7
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HIRA histone cell cycle regulator
HIST1H2AI histone cluster 1, H2ai
HIST1H3B histone cluster 1, H3b
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
KIAA0355 KIAA0355
KLHL36 kelch-like family member 36
KLK5 kallikrein-related peptidase 5
LAMB2 laminin, beta 2 (laminin S)
LHFPL2 lipoma HMGIC fusion partner-like 2
LOC390998 ribosomal protein L10 pseudogene
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRP5L low density lipoprotein receptor-related protein 5-like
LYPD1 LY6/PLAUR domain containing 1
LZTS3 leucine zipper, putative tumor suppressor family member 3
NKX3-2 NK3 homeobox 2
OCA2 oculocutaneous albinism II
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PCSK7 proprotein convertase subtilisin/kexin type 7
PGPEP1 pyroglutamyl-peptidase I
PLA2G3 phospholipase A2, group III
PRAF2 PRA1 domain family, member 2
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PTCD2 pentatricopeptide repeat domain 2
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RECQL4 RecQ protein-like 4
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RPL13P5 ribosomal protein L13 pseudogene 5
S100A9 S100 calcium binding protein A9
SCD5 stearoyl-CoA desaturase 5
SETD1A SET domain containing 1A
SFT2D2 SFT2 domain containing 2
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC12A9 solute carrier family 12, member 9
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SNAI2 snail family zinc finger 2
SOX12 SRY (sex determining region Y)-box 12
STARD13 StAR-related lipid transfer (START) domain containing 13
STRN striatin, calmodulin binding protein
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
THRAP3 thyroid hormone receptor associated protein 3
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TNRC6B trinucleotide repeat containing 6B
TPCN1 two pore segment channel 1
TSC22D4 TSC22 domain family, member 4
TSPYL2 TSPY-like 2
TUBA3C tubulin, alpha 3c
VEGFB vascular endothelial growth factor B
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
VPS9D1 VPS9 domain containing 1
ZMYM3 zinc finger, MYM-type 3
ZNF134 zinc finger protein 134
ZNF16 zinc finger protein 16
ZNF211 zinc finger protein 211
ZNF276 zinc finger protein 276
ZNF428 zinc finger protein 428
ZNF586 zinc finger protein 586
ZNF8 zinc finger protein 8
ZNRD1-AS1 ZNRD1 antisense RNA 1