brinzolamide-6670 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the brinzolamide-6670 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
AIM1L absent in melanoma 1-like
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
AURKC aurora kinase C
BAIAP2 BAI1-associated protein 2
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BMPR1B bone morphogenetic protein receptor, type IB
C17ORF53 chromosome 17 open reading frame 53
C3AR1 complement component 3a receptor 1
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CACYBP calcyclin binding protein
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCDC64 coiled-coil domain containing 64
CD68 CD68 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CERS4 ceramide synthase 4
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
CLEC11A C-type lectin domain family 11, member A
CSF1 colony stimulating factor 1 (macrophage)
DEFA4 defensin, alpha 4, corticostatin
DHRS12 dehydrogenase/reductase (SDR family) member 12
DHRS9 dehydrogenase/reductase (SDR family) member 9
DLX2 distal-less homeobox 2
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
EED embryonic ectoderm development
EGFL7 EGF-like-domain, multiple 7
FERMT2 fermitin family member 2
FGF22 fibroblast growth factor 22
GBP2 guanylate binding protein 2, interferon-inducible
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GPR85 G protein-coupled receptor 85
GSN-AS1 GSN antisense RNA 1
GYPC glycophorin C (Gerbich blood group)
GZMK granzyme K (granzyme 3; tryptase II)
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
INPP5J inositol polyphosphate-5-phosphatase J
IRF4 interferon regulatory factor 4
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNK13 potassium channel, two pore domain subfamily K, member 13
KMT2A lysine (K)-specific methyltransferase 2A
KRIT1 KRIT1, ankyrin repeat containing
KRT17 keratin 17, type I
LARP7 La ribonucleoprotein domain family, member 7
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LIMK2 LIM domain kinase 2
LOC100294391 uncharacterized LOC100294391
LRRK1 leucine-rich repeat kinase 1
MAPK11 mitogen-activated protein kinase 11
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MCF2L MCF.2 cell line derived transforming sequence-like
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
NOTCH2 notch 2
NTM neurotrimin
OAZ3 ornithine decarboxylase antizyme 3
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
OGFR opioid growth factor receptor
OVOL2 ovo-like zinc finger 2
OXCT2 3-oxoacid CoA transferase 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PGAP3 post-GPI attachment to proteins 3
PHF20L1 PHD finger protein 20-like 1
PLA2R1 phospholipase A2 receptor 1, 180kDa
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PRAMEF11 PRAME family member 11
PSG1 pregnancy specific beta-1-glycoprotein 1
PTPRJ protein tyrosine phosphatase, receptor type, J
RASA3 RAS p21 protein activator 3
RETN resistin
RPL35A ribosomal protein L35a
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNX13 sorting nexin 13
STXBP5L syntaxin binding protein 5-like
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
TAPBPL TAP binding protein-like
TBX5 T-box 5
TEX14 testis expressed 14
TMPRSS6 transmembrane protease, serine 6
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNPO2 transportin 2
TRIM15 tripartite motif containing 15
TRIM29 tripartite motif containing 29
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
WDR59 WD repeat domain 59
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZKSCAN5 zinc finger with KRAB and SCAN domains 5
ZNF287 zinc finger protein 287
ZNF334 zinc finger protein 334
ZNF573 zinc finger protein 573

decreased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ALPK1 alpha-kinase 1
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATAT1 alpha tubulin acetyltransferase 1
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BBC3 BCL2 binding component 3
BCL2L2 BCL2-like 2
C14ORF105 chromosome 14 open reading frame 105
C3 complement component 3
CD101 CD101 molecule
CIDEC cell death-inducing DFFA-like effector c
CLSPN claspin
CNGB3 cyclic nucleotide gated channel beta 3
CNIH3 cornichon family AMPA receptor auxiliary protein 3
CSF1R colony stimulating factor 1 receptor
CST1 cystatin SN
CTSK cathepsin K
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DENND5B DENN/MADD domain containing 5B
ERCC2 excision repair cross-complementation group 2
ERN2 endoplasmic reticulum to nucleus signaling 2
HIST1H2AK histone cluster 1, H2ak
HOMER2 homer scaffolding protein 2
HOXA7 homeobox A7
HOXC13 homeobox C13
IFT140 intraflagellar transport 140
IL36RN interleukin 36 receptor antagonist
ISYNA1 inositol-3-phosphate synthase 1
ITGB7 integrin, beta 7
KIAA0319L KIAA0319-like
KIAA1456 KIAA1456
KLK7 kallikrein-related peptidase 7
KRT20 keratin 20, type I
LAX1 lymphocyte transmembrane adaptor 1
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LPPR1 lipid phosphate phosphatase-related protein type 1
LY6G6C lymphocyte antigen 6 complex, locus G6C
MANBA mannosidase, beta A, lysosomal
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MED15 mediator complex subunit 15
MEGF8 multiple EGF-like-domains 8
MEIS1 Meis homeobox 1
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MTSS1L metastasis suppressor 1-like
MXRA8 matrix-remodelling associated 8
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative)
NAG18 NAG18 mRNA
NEK11 NIMA-related kinase 11
NID2 nidogen 2 (osteonidogen)
NKX3-2 NK3 homeobox 2
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PER3 period circadian clock 3
PLD2 phospholipase D2
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PPT2 palmitoyl-protein thioesterase 2
PRSS53 protease, serine, 53
RAB40A RAB40A, member RAS oncogene family
RAI2 retinoic acid induced 2
REM1 RAS (RAD and GEM)-like GTP-binding 1
RNF2 ring finger protein 2
ROM1 retinal outer segment membrane protein 1
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SIX3 SIX homeobox 3
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SLITRK5 SLIT and NTRK-like family, member 5
SNORA21 small nucleolar RNA, H/ACA box 21
SPINK5 serine peptidase inhibitor, Kazal type 5
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SYTL2 synaptotagmin-like 2
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TIGD6 tigger transposable element derived 6
TLR2 toll-like receptor 2
TMEM180 transmembrane protein 180
TMEM183A transmembrane protein 183A
TMSB15A thymosin beta 15a
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TTLL1 tubulin tyrosine ligase-like family member 1
TUBA3C tubulin, alpha 3c
USP20 ubiquitin specific peptidase 20
USP27X ubiquitin specific peptidase 27, X-linked
VASH1 vasohibin 1
XYLT2 xylosyltransferase II
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF197 zinc finger protein 197
ZNF391 zinc finger protein 391
ZNF671 zinc finger protein 671
ZNF702P zinc finger protein 702, pseudogene
ZNF747 zinc finger protein 747