breast cancer Gene Set

Dataset DISEASES Experimental Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A thoracic cancer that originates in the mammary gland. (Human Disease Ontology, DOID_1612)
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Genes

125 genes associated with the disease breast cancer in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
CCND1 cyclin D1 2.35465
MRPS30 mitochondrial ribosomal protein S30 1.94574
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 1.92218
POU5F1B POU class 5 homeobox 1B 1.65491
SHBG sex hormone-binding globulin 1.14929
CDYL2 chromodomain protein, Y-like 2 1.14929
ADAM29 ADAM metallopeptidase domain 29 1.12703
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 1.09962
DIRC3 disrupted in renal carcinoma 3 1.09588
PGPEP1 pyroglutamyl-peptidase I 1.04495
ELL elongation factor RNA polymerase II 1.04495
HNF4G hepatocyte nuclear factor 4, gamma 1.0394
EBF1 early B-cell factor 1 1.00628
KCNU1 potassium channel, subfamily U, member 1 1.00628
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.987984
ERBB4 erb-b2 receptor tyrosine kinase 4 0.968307
PAX9 paired box 9 0.945428
MDM4 MDM4, p53 regulator 0.872896
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.872896
UST uronyl-2-sulfotransferase 0.850113
SNX32 sorting nexin 32 0.820928
LSP1 lymphocyte-specific protein 1 0.790827
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5 0.738873
TERT telomerase reverse transcriptase 0.724323
AQP4 aquaporin 4 0.69843
ZNF221 zinc finger protein 221 0.69843
CCDC88C coiled-coil domain containing 88C 0.670996
TOX3 TOX high mobility group box family member 3 0.63207
BABAM1 BRISC and BRCA1 A complex member 1 0.602429
EMID1 EMI domain containing 1 0.58494
ZMIZ1 zinc finger, MIZ-type containing 1 0.572184
FOXQ1 forkhead box Q1 0.544585
RANBP9 RAN binding protein 9 0.537125
TBX5 T-box 5 0.52461
KLF4 Kruppel-like factor 4 (gut) 0.52461
STXBP4 syntaxin binding protein 4 0.52461
LGR6 leucine-rich repeat containing G protein-coupled receptor 6 0.52461
RALY RALY heterogeneous nuclear ribonucleoprotein 0.52461
DLX2 distal-less homeobox 2 0.52461
PEX14 peroxisomal biogenesis factor 14 0.52461
PTHLH parathyroid hormone-like hormone 0.52461
FGFR2 fibroblast growth factor receptor 2 0.52461
DCLRE1B DNA cross-link repair 1B 0.486425
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.486425
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.486425
PDE4D phosphodiesterase 4D, cAMP-specific 0.464771
CHST9 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 0.464771
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.464771
RNF146 ring finger protein 146 0.464771
CDCA7 cell division cycle associated 7 0.464771
TET2 tet methylcytosine dioxygenase 2 0.449873
ANKLE1 ankyrin repeat and LEM domain containing 1 0.449873
ATF7IP activating transcription factor 7 interacting protein 0.449873
FTO fat mass and obesity associated 0.449873
AREG amphiregulin 0.438544
BRCA2 breast cancer 2, early onset 0.438544
C10ORF11 chromosome 10 open reading frame 11 0.429338
SIAH2 siah E3 ubiquitin protein ligase 2 0.408752
ZNF365 zinc finger protein 365 0.403461
RAD51B RAD51 paralog B 0.403461
CCDC170 coiled-coil domain containing 170 0.403461
NEK10 NIMA-related kinase 10 0.368757
OSR1 odd-skipped related transciption factor 1 0.368757
EIF3H eukaryotic translation initiation factor 3, subunit H 0.345945
SOS2 son of sevenless homolog 2 (Drosophila) 0.345945
TNIP3 TNFAIP3 interacting protein 3 0.345945
HSCB HscB mitochondrial iron-sulfur cluster co-chaperone 0.327313
GLG1 golgi glycoprotein 1 0.327313
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 0.311576
EHD3 EH-domain containing 3 0.311576
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 0.311576
GDI2 GDP dissociation inhibitor 2 0.311576
CETN3 centrin, EF-hand protein, 3 0.285417
TNNT3 troponin T type 3 (skeletal, fast) 0.285417
BUB3 BUB3 mitotic checkpoint protein 0.285417
TCL1A T-cell leukemia/lymphoma 1A 0.285417
TBC1D2B TBC1 domain family, member 2B 0.285417
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 0.274608
WNT4 wingless-type MMTV integration site family, member 4 0.264872
DGKH diacylglycerol kinase, eta 0.256228
SNX17 sorting nexin 17 0.256228
ESR1 estrogen receptor 1 0.197766
PTMA prothymosin, alpha 0.197766
FHIT fragile histidine triad 0.197766
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) 0.197766
DIAPH3 diaphanous-related formin 3 0.197766
MKL1 megakaryoblastic leukemia (translocation) 1 0.197766
ATE1 arginyltransferase 1 0.197766
ROPN1L rhophilin associated tail protein 1-like 0.197766
PLEKHA8 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 0.197766
SNED1 sushi, nidogen and EGF-like domains 1 0.15771
FHOD3 formin homology 2 domain containing 3 0.15771
BEST1 bestrophin 1 0.15771
GPC5 glypican 5 0.15771
FAM46A family with sequence similarity 46, member A 0.15771
GRM7 glutamate receptor, metabotropic 7 0.15771
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.15771
LMOD1 leiomodin 1 (smooth muscle) 0.15771
CADPS Ca++-dependent secretion activator 0.126165
ZNF407 zinc finger protein 407 0.126165
GALC galactosylceramidase 0.126165
MYOCD myocardin 0.126165
PRSS55 protease, serine, 55 0.100789
PLXNC1 plexin C1 0.100789
ASB13 ankyrin repeat and SOCS box containing 13 0.100789
SLC45A1 solute carrier family 45, member 1 0.100789
OSBPL6 oxysterol binding protein-like 6 0.080593
DCLK1 doublecortin-like kinase 1 0.080593
PELI1 pellino E3 ubiquitin protein ligase 1 0.080593
USH2A Usher syndrome 2A (autosomal recessive, mild) 0.080593
CDON cell adhesion associated, oncogene regulated 0.080593
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.080593
DOCK4 dedicator of cytokinesis 4 0.080593
ZNF577 zinc finger protein 577 0.064973
NWD2 NACHT and WD repeat domain containing 2 0.052255
BCAS3 breast carcinoma amplified sequence 3 0.052255
ELMO1 engulfment and cell motility 1 0.052255
NXPH2 neurexophilin 2 0.052255
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 0.052255
RELN reelin 0.043246
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.043246
RBMS3 RNA binding motif, single stranded interacting protein 3 0.043246
PCSK1 proprotein convertase subtilisin/kexin type 1 0.043246
TLR6 toll-like receptor 6 0.035343
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 0.035343