bowel dysfunction Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
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Genes

263 genes co-occuring with the disease bowel dysfunction in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 2.39073
OPRM1 opioid receptor, mu 1 1.79075
GUCY2C guanylate cyclase 2C 1.73322
PYY peptide YY 1.6498
NPR1 natriuretic peptide receptor 1 1.64756
MLN motilin 1.63366
TAC1 tachykinin, precursor 1 1.49394
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.48296
APOLD1 apolipoprotein L domain containing 1 1.47989
CCK cholecystokinin 1.43508
ACHE acetylcholinesterase (Yt blood group) 1.40176
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 1.33545
VIP vasoactive intestinal peptide 1.22605
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.17808
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.17808
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2 1.16992
MLNR motilin receptor 1.05471
NKTR natural killer cell triggering receptor 1.04882
GHRL ghrelin/obestatin prepropeptide 1.0168
CYP2D7 cytochrome P450, family 2, subfamily D, polypeptide 7 (gene/pseudogene) 1.00879
RET ret proto-oncogene 0.999924
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 0.997814
TPH1 tryptophan hydroxylase 1 0.99233
CLCN2 chloride channel, voltage-sensitive 2 0.960797
SST somatostatin 0.955779
PPY pancreatic polypeptide 0.927519
MGP matrix Gla protein 0.917199
THRA thyroid hormone receptor, alpha 0.915551
CALCA calcitonin-related polypeptide alpha 0.886389
PTH parathyroid hormone 0.883521
KLB klotho beta 0.838066
ITM2B integral membrane protein 2B 0.833968
CAMP cathelicidin antimicrobial peptide 0.822077
CHRM3 cholinergic receptor, muscarinic 3 0.821667
TRPV1 transient receptor potential cation channel, subfamily V, member 1 0.818796
CCKAR cholecystokinin A receptor 0.811411
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.797872
PDPR pyruvate dehydrogenase phosphatase regulatory subunit 0.792951
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2 0.783936
ATG4C autophagy related 4C, cysteine peptidase 0.777386
ARRB1 arrestin, beta 1 0.772479
CHGA chromogranin A 0.768393
GAST gastrin 0.767985
FGF19 fibroblast growth factor 19 0.758601
ALB albumin 0.752492
ALPPL2 alkaline phosphatase, placental-like 2 0.752085
ALPP alkaline phosphatase, placental 0.751678
ALPL alkaline phosphatase, liver/bone/kidney 0.751271
CD79A CD79a molecule, immunoglobulin-associated alpha 0.751271
NPS neuropeptide S 0.745985
NPY neuropeptide Y 0.720461
INS insulin 0.718846
MME membrane metallo-endopeptidase 0.708364
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.704742
ATP5J ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6 0.702732
NTS neurotensin 0.702732
CPOX coproporphyrinogen oxidase 0.700321
PNOC prepronociceptin 0.69751
MNX1 motor neuron and pancreas homeobox 1 0.694301
GPBAR1 G protein-coupled bile acid receptor 1 0.693499
KLK3 kallikrein-related peptidase 3 0.6791
TACR1 tachykinin receptor 1 0.675909
FTL ferritin, light polypeptide 0.663181
FTH1 ferritin, heavy polypeptide 1 0.662784
MGAM maltase-glucoamylase 0.656441
MED12 mediator complex subunit 12 0.652089
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 0.651298
ACE angiotensin I converting enzyme 0.642615
EDEM2 ER degradation enhancer, mannosidase alpha-like 2 0.635528
TACR3 tachykinin receptor 3 0.632384
EDNRB endothelin receptor type B 0.631991
TCTE1 t-complex-associated-testis-expressed 1 0.63042
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 0.626888
L1CAM L1 cell adhesion molecule 0.614747
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.613574
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.613183
ELAVL3 ELAV like neuron-specific RNA binding protein 3 0.593674
SOX10 SRY (sex determining region Y)-box 10 0.591727
GPR161 G protein-coupled receptor 161 0.582384
EDN3 endothelin 3 0.582384
PER1 period circadian clock 1 0.581217
LY96 lymphocyte antigen 96 0.571107
NXPH1 neurexophilin 1 0.570329
AQP3 aquaporin 3 (Gill blood group) 0.562946
SRY sex determining region Y 0.55945
FAAH fatty acid amide hydrolase 0.557897
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.551298
TACR2 tachykinin receptor 2 0.550134
CSN1S1 casein alpha s1 0.547032
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.544318
KCTD5 potassium channel tetramerization domain containing 5 0.534248
ARRB2 arrestin, beta 2 0.530768
LCT lactase 0.526132
LRRK2 leucine-rich repeat kinase 2 0.525746
CHAT choline O-acetyltransferase 0.52343
FGFR4 fibroblast growth factor receptor 4 0.521888
GDNF glial cell derived neurotrophic factor 0.519961
PKNOX2 PBX/knotted 1 homeobox 2 0.518805
NTF3 neurotrophin 3 0.51534
CCKBR cholecystokinin B receptor 0.503058
PER2 period circadian clock 2 0.497321
MECP2 methyl CpG binding protein 2 0.497321
DPP4 dipeptidyl-peptidase 4 0.496939
TRPA1 transient receptor potential cation channel, subfamily A, member 1 0.495793
CRH corticotropin releasing hormone 0.492359
CAPS2 calcyphosine 2 0.487027
FLNA filamin A, alpha 0.476772
CRP C-reactive protein, pentraxin-related 0.476393
T T, brachyury homolog (mouse) 0.476014
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 0.475634
PDYN prodynorphin 0.463527
FOS FBJ murine osteosarcoma viral oncogene homolog 0.461639
GRP gastrin-releasing peptide 0.458996
TCF4 transcription factor 4 0.457864
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1 0.449947
GAL galanin/GMAP prepropeptide 0.449571
IGLV5-52 immunoglobulin lambda variable 5-52 0.439034
TF transferrin 0.436402
TH tyrosine hydroxylase 0.434148
CAPN8 calpain 8 0.433397
CD34 CD34 molecule 0.43227
PRKX protein kinase, X-linked 0.429642
IGLV2-14 immunoglobulin lambda variable 2-14 0.42589
TRH thyrotropin-releasing hormone 0.424389
NALCN sodium leak channel, non selective 0.421016
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 0.417644
COL4A6 collagen, type IV, alpha 6 0.41727
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast) 0.415398
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 0.412779
COMT catechol-O-methyltransferase 0.411283
MED4 mediator complex subunit 4 0.409414
SLCO6A1 solute carrier organic anion transporter family, member 6A1 0.40904
HMBS hydroxymethylbilane synthase 0.407919
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 0.407545
CCL16 chemokine (C-C motif) ligand 16 0.406051
TTR transthyretin 0.391885
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.391513
LARS leucyl-tRNA synthetase 0.390397
PTPN7 protein tyrosine phosphatase, non-receptor type 7 0.388166
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 0.382223
KRT7 keratin 7, type II 0.381481
SLC22A18 solute carrier family 22, member 18 0.373328
TCHH trichohyalin 0.373328
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.371847
ARMC10 armadillo repeat containing 10 0.371847
ENO2 enolase 2 (gamma, neuronal) 0.369258
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 0.363716
BCHE butyrylcholinesterase 0.361502
GCG glucagon 0.356341
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.355604
PNP purine nucleoside phosphorylase 0.355235
OPRK1 opioid receptor, kappa 1 0.352659
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 0.350452
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.347879
MPLKIP M-phase specific PLK1 interacting protein 0.344574
FGF2 fibroblast growth factor 2 (basic) 0.344207
OPRD1 opioid receptor, delta 1 0.342739
CALB2 calbindin 2 0.342006
PNLIP pancreatic lipase 0.337975
PRRC2A proline-rich coiled-coil 2A 0.336876
MAP9 microtubule-associated protein 9 0.335778
THRB thyroid hormone receptor, beta 0.325187
ADRA2A adrenoceptor alpha 2A 0.321909
LAX1 lymphocyte transmembrane adaptor 1 0.318272
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.316456
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.315366
XPO4 exportin 4 0.313915
LPCAT2 lysophosphatidylcholine acyltransferase 2 0.312464
CTSC cathepsin C 0.311377
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa 0.306672
PANX2 pannexin 2 0.303059
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 0.300533
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 0.295492
KRT20 keratin 20, type I 0.294772
REN renin 0.293694
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 0.292257
PURA purine-rich element binding protein A 0.29118
PRLH prolactin releasing hormone 0.290462
F2RL1 coagulation factor II (thrombin) receptor-like 1 0.289744
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.286877
RNF25 ring finger protein 25 0.285086
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.283297
NPR2 natriuretic peptide receptor 2 0.283297
CRHR1 corticotropin releasing hormone receptor 1 0.281868
FECH ferrochelatase 0.281153
FAT4 FAT atypical cadherin 4 0.280439
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 0.278654
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.272597
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 0.272597
JMJD6 jumonji domain containing 6 0.271886
TNF tumor necrosis factor 0.270108
SYP synaptophysin 0.265494
ERCC8 excision repair cross-complementation group 8 0.263722
OR10R2 olfactory receptor, family 10, subfamily R, member 2 0.263368
POMC proopiomelanocortin 0.262306
DTNA dystrobrevin, alpha 0.262306
OCLN occludin 0.25877
ARSH arylsulfatase family, member H 0.25877
KCNIP4 Kv channel interacting protein 4 0.258064
GGT1 gamma-glutamyltransferase 1 0.253127
CALD1 caldesmon 1 0.243645
CDAN1 codanin 1 0.243295
RNF19B ring finger protein 19B 0.242945
NR1D1 nuclear receptor subfamily 1, group D, member 1 0.238054
TUBB2A tubulin, beta 2A class IIa 0.237706
STPG1 sperm-tail PG-rich repeat containing 1 0.235268
NR1H4 nuclear receptor subfamily 1, group H, member 4 0.227642
SHKBP1 SH3KBP1 binding protein 1 0.227297
ALK anaplastic lymphoma receptor tyrosine kinase 0.224196
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 0.220766
WRNIP1 Werner helicase interacting protein 1 0.219057
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 0.218715
FABP6 fatty acid binding protein 6, ileal 0.214297
HRH2 histamine receptor H2 0.213283
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 0.210253
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon 0.210253
AVP arginine vasopressin 0.209918
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.209583
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.208579
IL2 interleukin 2 0.205916
TUBB tubulin, beta class I 0.204263
NCBP1 nuclear cap binding protein subunit 1, 80kDa 0.199033
SH2B1 SH2B adaptor protein 1 0.197099
CLEC2A C-type lectin domain family 2, member A 0.196779
PEX14 peroxisomal biogenesis factor 14 0.193915
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 0.192971
APOB apolipoprotein B 0.191097
HN1 hematological and neurological expressed 1 0.189244
SP9 Sp9 transcription factor 0.187719
ISPD isoprenoid synthase domain containing 0.187113
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 0.185313
CCNT1 cyclin T1 0.183835
FBXO42 F-box protein 42 0.181798
TRO trophinin 0.18151
DPP6 dipeptidyl-peptidase 6 0.181222
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 0.179802
CANX calnexin 0.178126
PHF20 PHD finger protein 20 0.177576
AKR1C4 aldo-keto reductase family 1, member C4 0.177576
COL3A1 collagen, type III, alpha 1 0.176757
NOS1 nitric oxide synthase 1 (neuronal) 0.175146
MAOA monoamine oxidase A 0.172291
AQP9 aquaporin 9 0.172038
IGLV5-48 immunoglobulin lambda variable 5-48 (non-functional) 0.171535
PLS3 plastin 3 0.171036
PARP2 poly (ADP-ribose) polymerase 2 0.169571
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.168854
LTF lactotransferrin 0.168148
TAC3 tachykinin 3 0.168148
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 0.166768
F2 coagulation factor II (thrombin) 0.166095
ZEB2 zinc finger E-box binding homeobox 2 0.165217
SPAG7 sperm associated antigen 7 0.164571
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa 0.163938
TMEM245 transmembrane protein 245 0.162505
THRSP thyroid hormone responsive 0.161331
HMGA2 high mobility group AT-hook 2 0.160387
ADCY1 adenylate cyclase 1 (brain) 0.159838
AQP4 aquaporin 4 0.158778
PTGER4 prostaglandin E receptor 4 (subtype EP4) 0.158605
DUSP3 dual specificity phosphatase 3 0.141172
KRT84 keratin 84, type II 0.141125
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 0.141091