bone Gene Set

Dataset TISSUES Curated Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description The hard form of connective tissue that constitutes the majority of the skeleton of most vertebrates; it consists of an organic component (the cells and matrix) and an inorganic, or mineral, component; the matrix contains a framework of collagenous fibers and is impregnated with the mineral component, chiefly calcium phosphate (85 per cent) and calcium carbonate (10 per cent), which imparts the quality of rigidity to bone. (BRENDA Tissue and Enzyme Source Ontology, BTO_0000140)
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Genes

240 proteins highly expressed in the tissue bone from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset.

Symbol Name
AARS alanyl-tRNA synthetase
ACOT12 acyl-CoA thioesterase 12
ACP5 acid phosphatase 5, tartrate resistant
ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
AEBP1 AE binding protein 1
AJAP1 adherens junctions associated protein 1
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
ALPL alkaline phosphatase, liver/bone/kidney
ANXA2 annexin A2
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
ARHGAP1 Rho GTPase activating protein 1
ARHGAP24 Rho GTPase activating protein 24
ARSJ arylsulfatase family, member J
ASB7 ankyrin repeat and SOCS box containing 7
ATAD1 ATPase family, AAA domain containing 1
ATAD3B ATPase family, AAA domain containing 3B
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BBS9 Bardet-Biedl syndrome 9
BCL2L2 BCL2-like 2
BGN biglycan
BMP5 bone morphogenetic protein 5
BMP6 bone morphogenetic protein 6
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALM2 calmodulin 2 (phosphorylase kinase, delta)
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CCDC80 coiled-coil domain containing 80
CCL28 chemokine (C-C motif) ligand 28
CCL7 chemokine (C-C motif) ligand 7
CCL8 chemokine (C-C motif) ligand 8
CCNL2 cyclin L2
CCT7 chaperonin containing TCP1, subunit 7 (eta)
CCT8 chaperonin containing TCP1, subunit 8 (theta)
CD47 CD47 molecule
CDC123 cell division cycle 123
CDC42EP5 CDC42 effector protein (Rho GTPase binding) 5
CDCA2 cell division cycle associated 2
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CLK1 CDC-like kinase 1
CNOT1 CCR4-NOT transcription complex, subunit 1
COL19A1 collagen, type XIX, alpha 1
COL1A1 collagen, type I, alpha 1
COL2A1 collagen, type II, alpha 1
COL5A2 collagen, type V, alpha 2
CTSK cathepsin K
CUEDC2 CUE domain containing 2
CXCL6 chemokine (C-X-C motif) ligand 6
CXORF57 chromosome X open reading frame 57
CYB5D2 cytochrome b5 domain containing 2
DBN1 drebrin 1
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24
DEPDC1 DEP domain containing 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLX5 distal-less homeobox 5
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2
ELOVL5 ELOVL fatty acid elongase 5
ERH enhancer of rudimentary homolog (Drosophila)
ETAA1 Ewing tumor-associated antigen 1
ETFA electron-transfer-flavoprotein, alpha polypeptide
EVA1B eva-1 homolog B (C. elegans)
FAM13A family with sequence similarity 13, member A
FAM3C family with sequence similarity 3, member C
FAM83G family with sequence similarity 83, member G
FOXD4 forkhead box D4
FOXF1 forkhead box F1
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FSD1 fibronectin type III and SPRY domain containing 1
GALNT16 polypeptide N-acetylgalactosaminyltransferase 16
GDF10 growth differentiation factor 10
GDF15 growth differentiation factor 15
GJC2 gap junction protein, gamma 2, 47kDa
GOSR2 golgi SNAP receptor complex member 2
GPR162 G protein-coupled receptor 162
GPSM1 G-protein signaling modulator 1
GSC goosecoid homeobox
GTDC1 glycosyltransferase-like domain containing 1
HAUS3 HAUS augmin-like complex, subunit 3
HAUS7 HAUS augmin-like complex, subunit 7
HDLBP high density lipoprotein binding protein
HELQ helicase, POLQ-like
HESX1 HESX homeobox 1
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
HOXB5 homeobox B5
HSPG2 heparan sulfate proteoglycan 2
ICE2 interactor of little elongation complex ELL subunit 2
IFI44L interferon-induced protein 44-like
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
IGFBP6 insulin-like growth factor binding protein 6
IL36B interleukin 36, beta
ITGA11 integrin, alpha 11
ITGA7 integrin, alpha 7
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITM2C integral membrane protein 2C
KTN1 kinectin 1 (kinesin receptor)
LAMC2 laminin, gamma 2
LARP6 La ribonucleoprotein domain family, member 6
LECT1 leukocyte cell derived chemotaxin 1
LIN7C lin-7 homolog C (C. elegans)
LRP5 low density lipoprotein receptor-related protein 5
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAP7D1 MAP7 domain containing 1
MCL1 myeloid cell leukemia 1
MCM3 minichromosome maintenance complex component 3
MCTS1 malignant T cell amplified sequence 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEPE matrix extracellular phosphoglycoprotein
MICA MHC class I polypeptide-related sequence A
MKLN1 muskelin 1, intracellular mediator containing kelch motifs
MMP9 matrix metallopeptidase 9
MSX2 msh homeobox 2
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NALCN sodium leak channel, non selective
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NEUROD1 neuronal differentiation 1
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NGEF neuronal guanine nucleotide exchange factor
NGRN neugrin, neurite outgrowth associated
NID2 nidogen 2 (osteonidogen)
NLRX1 NLR family member X1
NPTX1 neuronal pentraxin I
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
OMD osteomodulin
P3H2 prolyl 3-hydroxylase 2
PAMR1 peptidase domain containing associated with muscle regeneration 1
PANX1 pannexin 1
PDCD6IP programmed cell death 6 interacting protein
PDZD11 PDZ domain containing 11
PHEX phosphate regulating endopeptidase homolog, X-linked
PHOSPHO2 phosphatase, orphan 2
PISD phosphatidylserine decarboxylase
PKM pyruvate kinase, muscle
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
POM121 POM121 transmembrane nucleoporin
POM121C POM121 transmembrane nucleoporin C
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1
PREPL prolyl endopeptidase-like
PRMT2 protein arginine methyltransferase 2
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PRRT3 proline-rich transmembrane protein 3
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTK2 protein tyrosine kinase 2
PXDN peroxidasin
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAP1B RAP1B, member of RAS oncogene family
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
RB1CC1 RB1-inducible coiled-coil 1
RBBP6 retinoblastoma binding protein 6
RBM14 RNA binding motif protein 14
RBM4 RNA binding motif protein 4
RBMX RNA binding motif protein, X-linked
RBMXL1 RNA binding motif protein, X-linked-like 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RILPL1 Rab interacting lysosomal protein-like 1
RNF41 ring finger protein 41, E3 ubiquitin protein ligase
RPL15 ribosomal protein L15
RPL34 ribosomal protein L34
RPP30 ribonuclease P/MRP 30kDa subunit
RPS13 ribosomal protein S13
RPS18 ribosomal protein S18
RPS18P12 ribosomal protein S18 pseudogene 12
RPS5 ribosomal protein S5
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RUNX2 runt-related transcription factor 2
SCARB1 scavenger receptor class B, member 1
SCYL2 SCY1-like 2 (S. cerevisiae)
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SF1 splicing factor 1
SH3BGR SH3 domain binding glutamate-rich protein
SH3D19 SH3 domain containing 19
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
SLC44A1 solute carrier family 44 (choline transporter), member 1
SNRPG small nuclear ribonucleoprotein polypeptide G
SP7 Sp7 transcription factor
SPDL1 spindle apparatus coiled-coil protein 1
SPP2 secreted phosphoprotein 2, 24kDa
SS18 synovial sarcoma translocation, chromosome 18
SSX1 synovial sarcoma, X breakpoint 1
SSX2 synovial sarcoma, X breakpoint 2
SSX2B synovial sarcoma, X breakpoint 2B
SSX3 synovial sarcoma, X breakpoint 3
STC1 stanniocalcin 1
STC2 stanniocalcin 2
STK4 serine/threonine kinase 4
STRBP spermatid perinuclear RNA binding protein
SUMO2 small ubiquitin-like modifier 2
SYTL3 synaptotagmin-like 3
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
TBC1D22B TBC1 domain family, member 22B
TCEA3 transcription elongation factor A (SII), 3
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TGIF1 TGFB-induced factor homeobox 1
TGM3 transglutaminase 3
TGS1 trimethylguanosine synthase 1
TM4SF19 transmembrane 4 L six family member 19
TMEM119 transmembrane protein 119
TMEM91 transmembrane protein 91
TPM3 tropomyosin 3
TPR translocated promoter region, nuclear basket protein
TRIB2 tribbles pseudokinase 2
TRIM5 tripartite motif containing 5
TRMT5 tRNA methyltransferase 5
TSPAN31 tetraspanin 31
TTC41P tetratricopeptide repeat domain 41, pseudogene
TTN titin
TXN2 thioredoxin 2
UBE2K ubiquitin-conjugating enzyme E2K
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UCK2 uridine-cytidine kinase 2
USP6 ubiquitin specific peptidase 6
VEGFB vascular endothelial growth factor B
VIM vimentin
XPO5 exportin 5
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
XYLT2 xylosyltransferase II
YARS tyrosyl-tRNA synthetase
YIPF2 Yip1 domain family, member 2
ZBED8 zinc finger, BED-type containing 8
ZFYVE28 zinc finger, FYVE domain containing 28
ZNF12 zinc finger protein 12
ZNF211 zinc finger protein 211
ZNF429 zinc finger protein 429
ZNF628 zinc finger protein 628
ZNF695 zinc finger protein 695