bone remodeling Gene Set

Dataset Biocarta Pathways
Category structural or functional annotations
Type pathway
Description The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis. (Gene Ontology, GO_0046849)
External Link http://cgap.nci.nih.gov/Pathways/BioCarta/h_ranklPathway
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Genes

16 proteins participating in the bone remodeling pathway from the Biocarta Pathways dataset.

Symbol Name
CHUK conserved helix-loop-helix ubiquitous kinase
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNB1 interferon, beta 1, fibroblast
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IRF9 interferon regulatory factor 9
MAPK8 mitogen-activated protein kinase 8
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase