bone marrow-derived macrophage Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description Bone marrow-derived macrophages (BMM) are primary macrophage cells, derived from bone marrow cells in vitro in the presence of growth factors. (BRENDA Tissue and Enzyme Source Ontology, BTO_0004732)
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Genes

353 proteins co-occuring with the tissue bone marrow-derived macrophage in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
TLR4 toll-like receptor 4 1.99162
CSF1 colony stimulating factor 1 (macrophage) 1.98949
MYD88 myeloid differentiation primary response 88 1.95408
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 1.89098
TLR2 toll-like receptor 2 1.8507
TNF tumor necrosis factor 1.66757
NLRP3 NLR family, pyrin domain containing 3 1.57748
MRC1 mannose receptor, C type 1 1.5716
CSF1R colony stimulating factor 1 receptor 1.55989
CARD17 caspase recruitment domain family, member 17 1.53047
ARG1 arginase 1 1.48786
NLRC4 NLR family, CARD domain containing 4 1.45844
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.41307
TLR9 toll-like receptor 9 1.40754
STAT1 signal transducer and activator of transcription 1, 91kDa 1.33953
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 1.30568
CTSK cathepsin K 1.22469
LRRC3 leucine rich repeat containing 3 1.20022
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.18956
TLR3 toll-like receptor 3 1.15983
IRF3 interferon regulatory factor 3 1.14298
RETNLB resistin like beta 1.12305
FOS FBJ murine osteosarcoma viral oncogene homolog 1.10579
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 1.07485
APOE apolipoprotein E 1.07485
CCL2 chemokine (C-C motif) ligand 2 1.07397
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.07044
ACPP acid phosphatase, prostate 1.00458
IL6 interleukin 6 0.997601
NOS2 nitric oxide synthase 2, inducible 0.99586
HCK HCK proto-oncogene, Src family tyrosine kinase 0.980651
IRAK4 interleukin-1 receptor-associated kinase 4 0.977616
RIPK2 receptor-interacting serine-threonine kinase 2 0.973716
IL10 interleukin 10 0.973283
TLR6 toll-like receptor 6 0.96809
TLR1 toll-like receptor 1 0.952978
SYK spleen tyrosine kinase 0.945226
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 0.943935
LENG9 leukocyte receptor cluster (LRC) member 9 0.942645
IL1B interleukin 1, beta 0.932766
JUN jun proto-oncogene 0.921627
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.921627
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.916923
DUSP1 dual specificity phosphatase 1 0.914361
CCL3 chemokine (C-C motif) ligand 3 0.912653
LAMP1 lysosomal-associated membrane protein 1 0.901147
SNX5 sorting nexin 5 0.900721
LDLR low density lipoprotein receptor 0.89732
IL4 interleukin 4 0.89647
CD86 CD86 molecule 0.888405
IFNA1 interferon, alpha 1 0.881627
AIM2 absent in melanoma 2 0.876129
CXCL2 chemokine (C-X-C motif) ligand 2 0.871483
SLC48A1 solute carrier family 48 (heme transporter), member 1 0.867686
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.86642
TLR7 toll-like receptor 7 0.863891
ZC3H7A zinc finger CCCH-type containing 7A 0.860521
MAPK8 mitogen-activated protein kinase 8 0.846225
DCSTAMP dendrocyte expressed seven transmembrane protein 0.845805
FAM134C family with sequence similarity 134, member C 0.838672
SCARB1 scavenger receptor class B, member 1 0.838672
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.832385
OSCAR osteoclast associated, immunoglobulin-like receptor 0.831966
TSPAN14 tetraspanin 14 0.829034
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.828616
STAT2 signal transducer and activator of transcription 2, 113kDa 0.81983
CLEC4E C-type lectin domain family 4, member E 0.811473
HMGB1 high mobility group box 1 0.809386
PILRB paired immunoglobin-like type 2 receptor beta 0.804796
NOD1 nucleotide-binding oligomerization domain containing 1 0.795208
TRIM13 tripartite motif containing 13 0.788547
MEFV Mediterranean fever 0.785635
FEM1A fem-1 homolog a (C. elegans) 0.76157
IFNAR1 interferon (alpha, beta and omega) receptor 1 0.759914
IRF8 interferon regulatory factor 8 0.75495
GPR85 G protein-coupled receptor 85 0.752884
CD36 CD36 molecule (thrombospondin receptor) 0.741327
CD4 CD4 molecule 0.74009
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.735971
DUSP4 dual specificity phosphatase 4 0.735559
STAP1 signal transducing adaptor family member 1 0.733912
LY96 lymphocyte antigen 96 0.733912
CXCL10 chemokine (C-X-C motif) ligand 10 0.732677
NLRC5 NLR family, CARD domain containing 5 0.728152
WAS Wiskott-Aldrich syndrome 0.717061
HSH2D hematopoietic SH2 domain containing 0.717061
CYBB cytochrome b-245, beta polypeptide 0.71501
CIITA class II, major histocompatibility complex, transactivator 0.712139
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.7105
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.707221
IL12B interleukin 12B 0.706402
ZFP36L2 ZFP36 ring finger protein-like 2 0.705583
NLRP1 NLR family, pyrin domain containing 1 0.705173
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.701899
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.700671
ALPK1 alpha-kinase 1 0.700262
CDC42 cell division cycle 42 0.699035
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 0.699035
CD40 CD40 molecule, TNF receptor superfamily member 5 0.699035
CALCR calcitonin receptor 0.697399
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.695763
ATP10D ATPase, class V, type 10D 0.693311
SCARB2 scavenger receptor class B, member 2 0.688409
IL3 interleukin 3 0.686368
CH25H cholesterol 25-hydroxylase 0.683919
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.682695
TLR5 toll-like receptor 5 0.674543
JAK2 Janus kinase 2 0.671692
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.671285
NOD2 nucleotide-binding oligomerization domain containing 2 0.661523
HMOX1 heme oxygenase 1 0.655836
CTSS cathepsin S 0.652589
IL1A interleukin 1, alpha 0.651371
IRGM immunity-related GTPase family, M 0.649344
CTSB cathepsin B 0.643263
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.642048
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide 0.640428
RNF31 ring finger protein 31 0.637594
LARP7 La ribonucleoprotein domain family, member 7 0.635976
MMP9 matrix metallopeptidase 9 0.630314
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.628697
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.620621
IRF1 interferon regulatory factor 1 0.615377
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.611346
PTPRD protein tyrosine phosphatase, receptor type, D 0.607319
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.604904
PLSCR4 phospholipid scramblase 4 0.59405
CD302 CD302 molecule 0.59405
BTK Bruton agammaglobulinemia tyrosine kinase 0.59124
DEF6 differentially expressed in FDCP 6 homolog (mouse) 0.589234
CARD6 caspase recruitment domain family, member 6 0.587629
SPI1 Spi-1 proto-oncogene 0.586427
CD80 CD80 molecule 0.576415
NINJ1 ninjurin 1 0.574017
SLA Src-like-adaptor 0.57082
GAB3 GRB2-associated binding protein 3 0.561644
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 0.560449
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.559652
UNC93B1 unc-93 homolog B1 (C. elegans) 0.558457
TFEC transcription factor EC 0.557661
THOC5 THO complex 5 0.55607
CNPY3 canopy FGF signaling regulator 3 0.549709
CCL5 chemokine (C-C motif) ligand 5 0.548517
ZC3H12A zinc finger CCCH-type containing 12A 0.544946
EBF2 early B-cell factor 2 0.533856
IRAK2 interleukin-1 receptor-associated kinase 2 0.526744
MAVS mitochondrial antiviral signaling protein 0.518859
FGR FGR proto-oncogene, Src family tyrosine kinase 0.517678
USP18 ubiquitin specific peptidase 18 0.516497
TREM2 triggering receptor expressed on myeloid cells 2 0.516104
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.515317
ATG5 autophagy related 5 0.514924
CERK ceramide kinase 0.50275
CCL4 chemokine (C-C motif) ligand 4 0.500398
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 0.500398
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.500007
CHID1 chitinase domain containing 1 0.498048
IFNB1 interferon, beta 1, fibroblast 0.495309
RGMA repulsive guidance molecule family member a 0.492182
CCL17 chemokine (C-C motif) ligand 17 0.492182
CCL24 chemokine (C-C motif) ligand 24 0.491009
PLSCR3 phospholipid scramblase 3 0.487106
HLA-B major histocompatibility complex, class I, B 0.486326
PELI1 pellino E3 ubiquitin protein ligase 1 0.482817
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.478534
TGFB1 transforming growth factor, beta 1 0.478145
CD93 CD93 molecule 0.477367
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 0.474646
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 0.473869
PLAU plasminogen activator, urokinase 0.470763
IFIH1 interferon induced with helicase C domain 1 0.468436
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 0.467273
LYN LYN proto-oncogene, Src family tyrosine kinase 0.466498
C1QB complement component 1, q subcomponent, B chain 0.461465
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 0.461078
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.457987
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta 0.455284
KDM6B lysine (K)-specific demethylase 6B 0.451813
CCR2 chemokine (C-C motif) receptor 2 0.449886
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 0.449886
LGALS3 lectin, galactoside-binding, soluble, 3 0.447961
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.443731
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase 0.442578
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.441042
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.438739
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.438739
MBNL3 muscleblind-like splicing regulator 3 0.438356
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2) 0.437972
CD180 CD180 molecule 0.433757
CARD9 caspase recruitment domain family, member 9 0.428783
CD44 CD44 molecule (Indian blood group) 0.427636
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 0.426109
PTGES prostaglandin E synthase 0.419623
MAPK3 mitogen-activated protein kinase 3 0.418861
PRAMEF10 PRAME family member 10 0.418861
PKNOX1 PBX/knotted 1 homeobox 1 0.414673
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.414673
HDAC8 histone deacetylase 8 0.410491
ICAM1 intercellular adhesion molecule 1 0.410111
CISH cytokine inducible SH2-containing protein 0.407073
ART1 ADP-ribosyltransferase 1 0.405555
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 0.405176
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.40328
HAMP hepcidin antimicrobial peptide 0.40328
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 0.40328
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.402144
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 0.401007
GADD45B growth arrest and DNA-damage-inducible, beta 0.40025
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1 0.398357
ALOX15 arachidonate 15-lipoxygenase 0.390044
IL27RA interleukin 27 receptor, alpha 0.387781
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.387404
CLEC5A C-type lectin domain family 5, member A 0.387027
SQLE squalene epoxidase 0.385896
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha 0.382131
DCAF7 DDB1 and CUL4 associated factor 7 0.381003
SOCS1 suppressor of cytokine signaling 1 0.380627
ISG15 ISG15 ubiquitin-like modifier 0.379123
C1QC complement component 1, q subcomponent, C chain 0.378748
RDH8 retinol dehydrogenase 8 (all-trans) 0.377245
OASL 2'-5'-oligoadenylate synthetase-like 0.37687
STAT5A signal transducer and activator of transcription 5A 0.376494
HSPA4L heat shock 70kDa protein 4-like 0.374243
VAV3 vav 3 guanine nucleotide exchange factor 0.372743
LHCGR luteinizing hormone/choriogonadotropin receptor 0.370121
CCND1 cyclin D1 0.36825
HDAC7 histone deacetylase 7 0.367129
IRAK3 interleukin-1 receptor-associated kinase 3 0.364886
CD68 CD68 molecule 0.361901
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.360782
NSDHL NAD(P) dependent steroid dehydrogenase-like 0.360782
NLRP6 NLR family, pyrin domain containing 6 0.360409
CNN3 calponin 3, acidic 0.357802
IRAK1 interleukin-1 receptor-associated kinase 1 0.356686
GPR84 G protein-coupled receptor 84 0.354455
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 0.35334
DNASE1L1 deoxyribonuclease I-like 1 0.350743
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.34926
RGS18 regulator of G-protein signaling 18 0.348148
CUL4B cullin 4B 0.34371
AGER advanced glycosylation end product-specific receptor 0.342971
SQSTM1 sequestosome 1 0.342602
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma 0.341495
GBP2 guanylate binding protein 2, interferon-inducible 0.340019
CCL22 chemokine (C-C motif) ligand 22 0.33965
INPPL1 inositol polyphosphate phosphatase-like 1 0.336704
CD276 CD276 molecule 0.336336
S100A8 S100 calcium binding protein A8 0.335233
HDAC9 histone deacetylase 9 0.333763
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 0.333028
CXCL5 chemokine (C-X-C motif) ligand 5 0.330827
GAB2 GRB2-associated binding protein 2 0.328262
STEAP3 STEAP family member 3, metalloreductase 0.327896
MMP12 matrix metallopeptidase 12 0.327896
MAP2K3 mitogen-activated protein kinase kinase 3 0.323874
GPSM1 G-protein signaling modulator 1 0.320591
CER1 cerberus 1, DAN family BMP antagonist 0.315135
CLEC4D C-type lectin domain family 4, member D 0.312595
RNF19B ring finger protein 19B 0.312232
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 0.310059
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 0.309697
SHARPIN SHANK-associated RH domain interactor 0.307528
SAMHD1 SAM domain and HD domain 1 0.306805
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 0.303559
IRF5 interferon regulatory factor 5 0.301039
VAMP3 vesicle-associated membrane protein 3 0.301039
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 0.300679
IRF7 interferon regulatory factor 7 0.299242
LAMP2 lysosomal-associated membrane protein 2 0.297089
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.293508
GBA glucosidase, beta, acid 0.291722
P2RY12 purinergic receptor P2Y, G-protein coupled, 12 0.291365
NANP N-acetylneuraminic acid phosphatase 0.290652
CXCR2 chemokine (C-X-C motif) receptor 2 0.288514
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 0.287092
BBC3 BCL2 binding component 3 0.286736
PLA2G1B phospholipase A2, group IB (pancreas) 0.282483
IL1R1 interleukin 1 receptor, type I 0.28213
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 0.281423
IL10RB interleukin 10 receptor, beta 0.279659
PPARG peroxisome proliferator-activated receptor gamma 0.279307
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 0.277549
CREB1 cAMP responsive element binding protein 1 0.276495
RGCC regulator of cell cycle 0.274744
IL19 interleukin 19 0.272997
SNX1 sorting nexin 1 0.272649
TF transferrin 0.268828
IDI1 isopentenyl-diphosphate delta isomerase 1 0.266757
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) 0.266413
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.262986
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B 0.260945
EFHC1 EF-hand domain (C-terminal) containing 1 0.259929
MARCKS myristoylated alanine-rich protein kinase C substrate 0.259254
FXR1 fragile X mental retardation, autosomal homolog 1 0.258243
NLRX1 NLR family member X1 0.258243
FLOT1 flotillin 1 0.25457
PRG1 p53-responsive gene 1 0.251606
IER3 immediate early response 3 0.250953
CCL13 chemokine (C-C motif) ligand 13 0.249006
CELF4 CUGBP, Elav-like family member 4 0.248683
CD163 CD163 molecule 0.248361
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.247399
POLDIP3 polymerase (DNA-directed), delta interacting protein 3 0.246124
IL1RN interleukin 1 receptor antagonist 0.246124
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.24486
ANKH ANKH inorganic pyrophosphate transport regulator 0.24486
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.244232
SSPN sarcospan 0.243918
ACP5 acid phosphatase 5, tartrate resistant 0.243605
VEGFA vascular endothelial growth factor A 0.243294
PTPRE protein tyrosine phosphatase, receptor type, E 0.242672
TBK1 TANK-binding kinase 1 0.242054
GJB6 gap junction protein, beta 6, 30kDa 0.242054
TRPC3 transient receptor potential cation channel, subfamily C, member 3 0.241132
RUNX2 runt-related transcription factor 2 0.240216
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 0.238706
MPEG1 macrophage expressed 1 0.238406
GUSB glucuronidase, beta 0.237513
OPTN optineurin 0.235457
LPCAT2 lysophosphatidylcholine acyltransferase 2 0.235167
S1PR2 sphingosine-1-phosphate receptor 2 0.235167
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.234016
NOX1 NADPH oxidase 1 0.231206
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.231206
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 0.230656
FN1 fibronectin 1 0.23011
CCND2 cyclin D2 0.23011
WASH7P WAS protein family homolog 7 pseudogene 0.229839
WASH1 WAS protein family homolog 1 0.227707
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.227186
ALOX5 arachidonate 5-lipoxygenase 0.226926
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.224893
WASH6P WAS protein family homolog 6 pseudogene 0.224398
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 0.223419
VILL villin-like 0.222938
CTSL cathepsin L 0.222699
DCLK3 doublecortin-like kinase 3 0.222699
GAS2 growth arrest-specific 2 0.222699
GUCY2C guanylate cyclase 2C 0.22246
RAMP2 receptor (G protein-coupled) activity modifying protein 2 0.221521
NPR1 natriuretic peptide receptor 1 0.221291
CX3CL1 chemokine (C-X3-C motif) ligand 1 0.221061
RAMP1 receptor (G protein-coupled) activity modifying protein 1 0.221061
IGF2R insulin-like growth factor 2 receptor 0.219707
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.219485
IL2 interleukin 2 0.219485
FCF1 FCF1 rRNA-processing protein 0.218186
PI3 peptidase inhibitor 3, skin-derived 0.217346
MARCO macrophage receptor with collagenous structure 0.215341
JAK3 Janus kinase 3 0.213471
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.213291
TICAM1 toll-like receptor adaptor molecule 1 0.213112
CSTB cystatin B (stefin B) 0.212586