bone giant cell tumor Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A giant cell tumor and bone cancer and bone tissue neoplasm that results_in the presence of multinucleated giant cells (osteoclast-like cell). (Human Disease Ontology, DOID_4305)
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Genes

116 genes co-occuring with the disease bone giant cell tumor in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A 1.59117
ACPP acid phosphatase, prostate 1.57512
CALCA calcitonin-related polypeptide alpha 1.36858
CD68 CD68 molecule 1.25907
SH3BP2 SH3-domain binding protein 2 1.191
CTSK cathepsin K 1.13585
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.04377
SEBOX SEBOX homeobox 1.01512
RGS12 regulator of G-protein signaling 12 0.988535
USP6 ubiquitin specific peptidase 6 0.984321
FLRT2 fibronectin leucine rich transmembrane protein 2 0.952021
ZNF133 zinc finger protein 133 0.938704
SIGLEC15 sialic acid binding Ig-like lectin 15 0.932898
PTH parathyroid hormone 0.870006
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 0.865502
ONECUT2 one cut homeobox 2 0.848307
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 0.84544
CALCR calcitonin receptor 0.819206
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.803616
ACP5 acid phosphatase 5, tartrate resistant 0.759416
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 0.751678
THBS3 thrombospondin 3 0.745172
DNAH8 dynein, axonemal, heavy chain 8 0.736243
CTSS cathepsin S 0.726524
PTHLH parathyroid hormone-like hormone 0.717232
TUBA1C tubulin, alpha 1c 0.705949
RUNX2 runt-related transcription factor 2 0.703536
MMP13 matrix metallopeptidase 13 0.699919
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 0.681096
ALPPL2 alkaline phosphatase, placental-like 2 0.650903
ALPP alkaline phosphatase, placental 0.650508
ALPL alkaline phosphatase, liver/bone/kidney 0.649718
ADAM12 ADAM metallopeptidase domain 12 0.642221
LYZ lysozyme 0.640645
MMP9 matrix metallopeptidase 9 0.609276
TXNRD2 thioredoxin reductase 2 0.608494
PTH1R parathyroid hormone 1 receptor 0.586665
TUBB2A tubulin, beta 2A class IIa 0.581606
DIO3 deiodinase, iodothyronine, type III 0.561392
SPP1 secreted phosphoprotein 1 0.547419
TUBB tubulin, beta class I 0.543542
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide 0.537731
BGLAP bone gamma-carboxyglutamate (gla) protein 0.512264
SLC25A18 solute carrier family 25 (glutamate carrier), member 18 0.501527
CA2 carbonic anhydrase II 0.498467
CCL23 chemokine (C-C motif) ligand 23 0.493885
ADCY1 adenylate cyclase 1 (brain) 0.480566
ACP2 acid phosphatase 2, lysosomal 0.469954
TP53 tumor protein p53 0.460129
PTPRC protein tyrosine phosphatase, receptor type, C 0.4443
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.425514
TERF2 telomeric repeat binding factor 2 0.420641
ADAM28 ADAM metallopeptidase domain 28 0.419142
POT1 protection of telomeres 1 0.409414
PLAU plasminogen activator, urokinase 0.395235
VCL vinculin 0.394863
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B 0.368888
ADAM8 ADAM metallopeptidase domain 8 0.365562
CCR1 chemokine (C-C motif) receptor 1 0.356709
H3F3A H3 histone, family 3A 0.349349
H3F3B H3 histone, family 3B (H3.3B) 0.349349
ATP11A ATPase, class VI, type 11A 0.340173
TPP1 tripeptidyl peptidase I 0.323002
AIF1 allograft inflammatory factor 1 0.316092
ITGAV integrin, alpha V 0.315003
VIM vimentin 0.31464
TPX2 TPX2, microtubule-associated 0.312102
MMP2 matrix metallopeptidase 2 0.305226
FGF3 fibroblast growth factor 3 0.299092
TGFB2 transforming growth factor, beta 2 0.295492
ALCAM activated leukocyte cell adhesion molecule 0.281868
IL1B interleukin 1, beta 0.28151
CCND1 cyclin D1 0.272953
SFRP4 secreted frizzled-related protein 4 0.264785
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.258417
PCNA proliferating cell nuclear antigen 0.258064
THBS1 thrombospondin 1 0.24996
CXCL12 chemokine (C-X-C motif) ligand 12 0.247852
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa 0.246799
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 0.235616
TGFB1 transforming growth factor, beta 1 0.235616
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.235268
THRA thyroid hormone receptor, alpha 0.233878
FRZB frizzled-related protein 0.21974
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.21974
EWSR1 EWS RNA-binding protein 1 0.217352
NFIB nuclear factor I/B 0.215992
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.211261
GCGR glucagon receptor 0.211261
CCNB1 cyclin B1 0.206913
DLK1 delta-like 1 homolog (Drosophila) 0.204923
CCL8 chemokine (C-C motif) ligand 8 0.200331
CASP6 caspase 6, apoptosis-related cysteine peptidase 0.194232
MSX1 msh homeobox 1 0.189859
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 0.180652
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 0.180652
FN1 fibronectin 1 0.17952
CSF1 colony stimulating factor 1 (macrophage) 0.178682
IL1R1 interleukin 1 receptor, type I 0.177301
PGM1 phosphoglucomutase 1 0.173571
CASR calcium-sensing receptor 0.173057
TGFB3 transforming growth factor, beta 3 0.171036
IBSP integrin-binding sialoprotein 0.169091
HK2 hexokinase 2 0.167452
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.166319
IL6 interleukin 6 0.166095
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.162306
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 0.158097
GUSB glucuronidase, beta 0.157765
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.14765
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.145259
S100A8 S100 calcium binding protein A8 0.144895
MITF microphthalmia-associated transcription factor 0.144515
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.14449
TNC tenascin C 0.142665
NF1 neurofibromin 1 0.142037