bone deterioration disease Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A bone structure disease that results_in change or damage of structure located_in bone. (Human Disease Ontology, DOID_0080007)
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Genes

170 genes co-occuring with the disease bone deterioration disease in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
IVD isovaleryl-CoA dehydrogenase 2.38609
ACAN aggrecan 1.88898
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 1.88528
COL6A1 collagen, type VI, alpha 1 1.57289
BMP2 bone morphogenetic protein 2 1.51809
BMP7 bone morphogenetic protein 7 1.28261
CCDC34 coiled-coil domain containing 34 1.1635
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa 1.12783
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 1.06102
TSSK4 testis-specific serine kinase 4 1.05345
KLK8 kallikrein-related peptidase 8 1.04335
CALCA calcitonin-related polypeptide alpha 1.01301
COL9A2 collagen, type IX, alpha 2 0.997814
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 0.994017
NFYC nuclear transcription factor Y, gamma 0.942443
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 0.942027
DCD dermcidin 0.941611
APLF aprataxin and PNKP like factor 0.925452
TBPL1 TBP-like 1 0.89582
TRIM68 tripartite motif containing 68 0.892129
COL9A3 collagen, type IX, alpha 3 0.881882
SOX9 SRY (sex determining region Y)-box 9 0.880653
MMP13 matrix metallopeptidase 13 0.874509
MMP3 matrix metallopeptidase 3 0.859771
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.847488
TMTC1 transmembrane and tetratricopeptide repeat containing 1 0.812642
FBXW2 F-box and WD repeat domain containing 2 0.794591
LAX1 lymphocyte transmembrane adaptor 1 0.793361
GDF5 growth differentiation factor 5 0.738271
AVPR2 arginine vasopressin receptor 2 0.73746
HSF4 heat shock transcription factor 4 0.731786
VAT1 vesicle amine transport 1 0.72612
SDC4 syndecan 4 0.67551
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase 0.655254
C1ORF167 chromosome 1 open reading frame 167 0.653276
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 0.648928
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.646165
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 0.632384
FMOD fibromodulin 0.617094
IDS iduronate 2-sulfatase 0.615921
TRPC3 transient receptor potential cation channel, subfamily C, member 3 0.606152
NOL9 nucleolar protein 9 0.592506
PIAS2 protein inhibitor of activated STAT, 2 0.582773
BGN biglycan 0.582384
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like 0.572273
TIMP1 TIMP metallopeptidase inhibitor 1 0.571495
ARSD arylsulfatase D 0.562946
JAG2 jagged 2 0.552075
GALNS galactosamine (N-acetyl)-6-sulfatase 0.550911
AMIGO2 adhesion molecule with Ig-like domain 2 0.541605
FTH1 ferritin, heavy polypeptide 1 0.524202
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.506507
ADGRL4 adhesion G protein-coupled receptor L4 0.501527
FGFR3 fibroblast growth factor receptor 3 0.493503
CD2BP2 CD2 (cytoplasmic tail) binding protein 2 0.491215
PDXK pyridoxal (pyridoxine, vitamin B6) kinase 0.485505
BMPR1B bone morphogenetic protein receptor, type IB 0.474119
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3 0.468441
CD6 CD6 molecule 0.468063
ARSE arylsulfatase E (chondrodysplasia punctata 1) 0.455224
KERA keratocan 0.454847
NOTCH1 notch 1 0.446935
LIF leukemia inhibitory factor 0.445429
TIMP2 TIMP metallopeptidase inhibitor 2 0.431894
IL18RAP interleukin 18 receptor accessory protein 0.430017
COL9A1 collagen, type IX, alpha 1 0.429266
BID BH3 interacting domain death agonist 0.427015
MMP1 matrix metallopeptidase 1 0.426265
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.413901
POMP proteasome maturation protein 0.405305
NOTCH2 notch 2 0.399334
NOTCH2NL notch 2 N-terminal like 0.396725
TGFB1 transforming growth factor, beta 1 0.393001
LSR lipolysis stimulated lipoprotein receptor 0.381852
HTRA1 HtrA serine peptidase 1 0.369628
PSAT1 phosphoserine aminotransferase 1 0.363716
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.362239
TBX1 T-box 1 0.361502
ALPPL2 alkaline phosphatase, placental-like 2 0.359289
ALPP alkaline phosphatase, placental 0.358551
ALPL alkaline phosphatase, liver/bone/kidney 0.358183
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.35082
MIA melanoma inhibitory activity 0.349349
PARP14 poly (ADP-ribose) polymerase family, member 14 0.344574
BGLAP bone gamma-carboxyglutamate (gla) protein 0.34384
MMP2 matrix metallopeptidase 2 0.340906
COMT catechol-O-methyltransferase 0.318999
CRP C-reactive protein, pentraxin-related 0.314278
COL2A1 collagen, type II, alpha 1 0.313189
EGLN3 egl-9 family hypoxia-inducible factor 3 0.309204
DST dystonin 0.305948
COL11A2P1 collagen, type XI, alpha 2 pseudogene 1 0.301976
COL11A2 collagen, type XI, alpha 2 0.301615
FN1 fibronectin 1 0.299092
THBS2 thrombospondin 2 0.298731
JAG1 jagged 1 0.298371
GHR growth hormone receptor 0.295132
ECI1 enoyl-CoA delta isomerase 1 0.28616
FGF9 fibroblast growth factor 9 0.281153
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 0.280082
BBS4 Bardet-Biedl syndrome 4 0.276158
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 0.274376
DCN decorin 0.27153
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta 0.270819
TAC1 tachykinin, precursor 1 0.261952
BBC3 BCL2 binding component 3 0.257005
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 0.253127
HMGA2 high mobility group AT-hook 2 0.25207
COL11A1 collagen, type XI, alpha 1 0.246098
ASPN asporin 0.245747
AMY2A amylase, alpha 2A (pancreatic) 0.245046
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 0.242945
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 0.238054
SHOX short stature homeobox 0.23666
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 0.232836
TIMP3 TIMP metallopeptidase inhibitor 3 0.222822
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.220081
TSKU tsukushi, small leucine rich proteoglycan 0.218374
GLB1 galactosidase, beta 1 0.214297
CD44 CD44 molecule (Indian blood group) 0.214297
IL1B interleukin 1, beta 0.212608
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.211934
LARGE like-glycosyltransferase 0.210589
TLR2 toll-like receptor 2 0.199356
OR10K1 olfactory receptor, family 10, subfamily K, member 1 0.199033
MARK3 MAP/microtubule affinity-regulating kinase 3 0.19582
MARK2 MAP/microtubule affinity-regulating kinase 2 0.195183
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.18591
BMPR1A bone morphogenetic protein receptor, type IA 0.184424
SP7 Sp7 transcription factor 0.183541
NPS neuropeptide S 0.181798
CALCR calcitonin receptor 0.179802
COL1A2 collagen, type I, alpha 2 0.176215
NT5C 5', 3'-nucleotidase, cytosolic 0.175146
FAM195A family with sequence similarity 195, member A 0.169571
ECE1 endothelin converting enzyme 1 0.168617
TERT telomerase reverse transcriptase 0.162707
SLC35B2 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2 0.161716
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 0.139944
FGF1 fibroblast growth factor 1 (acidic) 0.139172
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.139115
IDUA iduronidase, alpha-L- 0.139011
DNASE1 deoxyribonuclease I 0.138929
FGF8 fibroblast growth factor 8 (androgen-induced) 0.138846
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 0.138602
EPHA4 EPH receptor A4 0.138589
SIRT2 sirtuin 2 0.138576
LUM lumican 0.138463
TLR4 toll-like receptor 4 0.13796
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 0.137765
CYR61 cysteine-rich, angiogenic inducer, 61 0.137636
SHH sonic hedgehog 0.137622
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 0.137578
FTO fat mass and obesity associated 0.137534
MMP9 matrix metallopeptidase 9 0.137491
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 0.137371
GPANK1 G patch domain and ankyrin repeats 1 0.137356
GCH1 GTP cyclohydrolase 1 0.136907
TLR1 toll-like receptor 1 0.13648
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 0.136429
HSF1 heat shock transcription factor 1 0.136378
LY96 lymphocyte antigen 96 0.136378
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 0.136327
CREM cAMP responsive element modulator 0.13617
MMP10 matrix metallopeptidase 10 0.135938
CNTF ciliary neurotrophic factor 0.135755
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.135179
DES desmin 0.134997
PGRMC1 progesterone receptor membrane component 1 0.134997
C7ORF49 chromosome 7 open reading frame 49 0.134792