bisoprolol-6748 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the bisoprolol-6748 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A1CF APOBEC1 complementation factor
ACTA1 actin, alpha 1, skeletal muscle
ACVR1B activin A receptor, type IB
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6
AHNAK AHNAK nucleoprotein
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
ALDOB aldolase B, fructose-bisphosphate
AURKA aurora kinase A
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BMP8B bone morphogenetic protein 8b
BTN3A2 butyrophilin, subfamily 3, member A2
CCDC71 coiled-coil domain containing 71
CCL22 chemokine (C-C motif) ligand 22
CD6 CD6 molecule
CDC42 cell division cycle 42
CLSTN3 calsyntenin 3
COL3A1 collagen, type III, alpha 1
CSF1R colony stimulating factor 1 receptor
CXCL5 chemokine (C-X-C motif) ligand 5
DHRS7 dehydrogenase/reductase (SDR family) member 7
DMP1 dentin matrix acidic phosphoprotein 1
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
EBF2 early B-cell factor 2
EGFL7 EGF-like-domain, multiple 7
ELAVL3 ELAV like neuron-specific RNA binding protein 3
ELOVL5 ELOVL fatty acid elongase 5
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ESR1 estrogen receptor 1
ETV6 ets variant 6
EZR ezrin
FAM134B family with sequence similarity 134, member B
FAM63A family with sequence similarity 63, member A
FDPS farnesyl diphosphate synthase
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPATCH4 G patch domain containing 4
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GPR21 G protein-coupled receptor 21
GPSM3 G-protein signaling modulator 3
GUK1 guanylate kinase 1
HIPK3 homeodomain interacting protein kinase 3
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KIAA1467 KIAA1467
KIF21B kinesin family member 21B
KRAS Kirsten rat sarcoma viral oncogene homolog
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LAMB4 laminin, beta 4
LAPTM5 lysosomal protein transmembrane 5
LPL lipoprotein lipase
MAGEA5 melanoma antigen family A5
MAP3K13 mitogen-activated protein kinase kinase kinase 13
MCOLN3 mucolipin 3
MEG3 maternally expressed 3 (non-protein coding)
MEGF6 multiple EGF-like-domains 6
MFAP3L microfibrillar-associated protein 3-like
MRPL41 mitochondrial ribosomal protein L41
MTMR3 myotubularin related protein 3
MTUS1 microtubule associated tumor suppressor 1
NCKAP1 NCK-associated protein 1
NF1 neurofibromin 1
NPPA natriuretic peptide A
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRN1 neuritin 1
OGFR opioid growth factor receptor
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OR12D3 olfactory receptor, family 12, subfamily D, member 3
PASK PAS domain containing serine/threonine kinase
PDE5A phosphodiesterase 5A, cGMP-specific
PDLIM3 PDZ and LIM domain 3
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRKCE protein kinase C, epsilon
PRM1 protamine 1
PSD pleckstrin and Sec7 domain containing
RAB11B RAB11B, member RAS oncogene family
RPA4 replication protein A4, 30kDa
RPS3A ribosomal protein S3A
SAYSD1 SAYSVFN motif domain containing 1
SFRP4 secreted frizzled-related protein 4
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SGSM3 small G protein signaling modulator 3
SHMT1 serine hydroxymethyltransferase 1 (soluble)
TAL1 T-cell acute lymphocytic leukemia 1
TAS2R1 taste receptor, type 2, member 1
TMEM231 transmembrane protein 231
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TP63 tumor protein p63
TTC30A tetratricopeptide repeat domain 30A
TYMS thymidylate synthetase
VDAC3 voltage-dependent anion channel 3
YIPF4 Yip1 domain family, member 4
ZBTB20 zinc finger and BTB domain containing 20
ZFAND5 zinc finger, AN1-type domain 5
ZFHX2 zinc finger homeobox 2
ZNF230 zinc finger protein 230
ZNF334 zinc finger protein 334
ZNF639 zinc finger protein 639

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
ADAM23 ADAM metallopeptidase domain 23
AFAP1 actin filament associated protein 1
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
APOC4 apolipoprotein C-IV
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BAK1 BCL2-antagonist/killer 1
C11ORF63 chromosome 11 open reading frame 63
CARTPT CART prepropeptide
CASP5 caspase 5, apoptosis-related cysteine peptidase
CCDC132 coiled-coil domain containing 132
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CD101 CD101 molecule
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CNN1 calponin 1, basic, smooth muscle
CPZ carboxypeptidase Z
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein)
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DCSTAMP dendrocyte expressed seven transmembrane protein
DDN dendrin
DTX2 deltex 2, E3 ubiquitin ligase
ELSPBP1 epididymal sperm binding protein 1
EPHA7 EPH receptor A7
EPN1 epsin 1
ERMAP erythroblast membrane-associated protein (Scianna blood group)
EYA3 EYA transcriptional coactivator and phosphatase 3
FAM188A family with sequence similarity 188, member A
FBRS fibrosin
FBXL15 F-box and leucine-rich repeat protein 15
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FRMPD1 FERM and PDZ domain containing 1
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GAS8 growth arrest-specific 8
GATA4 GATA binding protein 4
GIF gastric intrinsic factor (vitamin B synthesis)
GPC3 glypican 3
GRAMD1C GRAM domain containing 1C
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H2AI histone cluster 1, H2ai
HIST1H3A histone cluster 1, H3a
HOMER2 homer scaffolding protein 2
HOXA7 homeobox A7
HSPA1L heat shock 70kDa protein 1-like
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
ICOS inducible T-cell co-stimulator
IFT140 intraflagellar transport 140
IL36RN interleukin 36 receptor antagonist
KLHL12 kelch-like family member 12
KLHL36 kelch-like family member 36
KRT20 keratin 20, type I
KRT34 keratin 34, type I
LAMC3 laminin, gamma 3
LIME1 Lck interacting transmembrane adaptor 1
MAGEH1 melanoma antigen family H1
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MRPL44 mitochondrial ribosomal protein L44
MTSS1L metastasis suppressor 1-like
MYH15 myosin, heavy chain 15
NABP2 nucleic acid binding protein 2
NEUROD1 neuronal differentiation 1
NPFFR1 neuropeptide FF receptor 1
NSUN6 NOP2/Sun domain family, member 6
PCDH12 protocadherin 12
PCDHA5 protocadherin alpha 5
PRAMEF10 PRAME family member 10
PRF1 perforin 1 (pore forming protein)
PRICKLE3 prickle homolog 3 (Drosophila)
PTK6 protein tyrosine kinase 6
PTK7 protein tyrosine kinase 7 (inactive)
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
SAMD9 sterile alpha motif domain containing 9
SCN1B sodium channel, voltage gated, type I beta subunit
SCUBE3 signal peptide, CUB domain, EGF-like 3
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC46A3 solute carrier family 46, member 3
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SMR3A submaxillary gland androgen regulated protein 3A
SPRYD7 SPRY domain containing 7
STON1 stonin 1
TBXAS1 thromboxane A synthase 1 (platelet)
TESPA1 thymocyte expressed, positive selection associated 1
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRAPPC13 trafficking protein particle complex 13
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TUBB2B tubulin, beta 2B class IIb
WDR18 WD repeat domain 18
WDR4 WD repeat domain 4
ZBTB33 zinc finger and BTB domain containing 33
ZNF253 zinc finger protein 253
ZNF471 zinc finger protein 471